Lipoyl synthase

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Lipoyl synthase
Identifiers
EC number 2.8.1.8
CAS number 189398-80-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a lipoyl synthase (EC 2.8.1.8) is an enzyme that catalyzes the chemical reaction

protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine \rightleftharpoons protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine

The 3 substrates of this enzyme are protein N6-(octanoyl)lysine, sulfur, and S-adenosyl-L-methionine, whereas its 3 products are protein N6-(lipoyl)lysine, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. This enzyme participates in lipoic acid metabolism, where it performs the final step in lipoic acid biosynthesis.

Nomenclature[edit]

The systematic name of this enzyme class is protein N6-(octanoyl)lysine:sulfur sulfurtransferase. Other names in common use include:

  • LS,
  • LipA,
  • lipoate synthase, and
  • protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase.

References[edit]