In 1985, Maxwell won a TV vote to become a presenter on BBC2 pop music show No Limits. The other winning presenter was Jeremy Legg.
She then went on to become a presenter on a number of children's programmes including Children's ITV flagship magazine programme Splash!. In March 2009 she appeared as a new co-presenter on ITV's daytime chat show, Loose Women. However soon after starting she was forced to take a break after she fractured two ribs. She returned to the show on 10 June 2009.
In April 2009, during an appearance on The Paul O'Grady Show, Lisa revealed the deciding factor in her leaving was the long hours she worked on The Bill and that she had suffered two miscarriages during 2008. She also said her friend and co-star Roberta Taylor had convinced her to leave the show for the sake of her health.
Maxwell has never married. On 28 February 2012, just before a leap day (which would be the traditional day for a woman to propose), she proposed to her long-term partner Paul Jessup, with whom she has been in a relationship since 1997. She has one child with Jessup, a daughter who was born in October 1999, called Beau. Maxwell lives in the Cotswolds.