Originally a S.H.I.E.L.D. black ops specialist, Ward is revealed to be a Hydra agent in "Turn, Turn, Turn". He was recruited by John Garrett to Hydra as a teenager in a flashback in "Ragtag". He was arrested in "Beginning of the End", and is seen imprisoned in a Playground cell in "Shadows". He escaped from S.H.I.E.L.D custody in "A Fractured House". Ward did not appear in "Heavy is the Head" and "Face My Enemy". Prior to revealing his Hydra loyalties, Ward had engaged in a discreet physical relationship with Agent May, and later revealed his romantic feelings for Skye. During his imprisonment in the Playground base, he would only provide intelligence to Skye, and expressed remorse for his actions towards Fitz and Simmons in "Ragtag". After escaping S.H.I.E.L.D. custody, Ward kills his brother and parents and joins Daniel Whitehall, but actually has his own agenda reuniting Skye with her father in order to gain her affection. Skye shoots Ward, but he escapes with Agent 33.
A civilian recruit who is a computer hacker and member of a hacktivist group called "the Rising Tide". She becomes a S.H.I.E.L.D. agent in "End of the Beginning". In "Ragtag", Raina revealed that Skye was the child of unidentified monsters that attacked a village in China. It is revealed in "The Things We Bury" that Skye's mother was killed by Daniel Whitehall, who experimented on her to learn why she does not age. In "What They Become", she learns that her birth name is Daisy and that she is an Inhuman.
A S.H.I.E.L.D. engineer that specializes in weapons technology. He later suffered brain damage from oxygen deprivation in "Beginning of the End", diminishing his ability to perform his job and causing him to suffer hallucinations of Simmons when she is not present.
An agent of S.H.I.E.L.D. who specializes in life sciences (both human and alien). Simmons leaves the team between the events of "Beginning of the End" and "Shadows" to become a mole inside of Hydra Laboratories. She later returns to S.H.I.E.L.D. in "A Hen in the Wolf House" after being rescued by Agent Morse and has a lukewarm reunion with Fitz.
A former member of SAS and mercenary who joins S.H.I.E.L.D. in "Heavy is the Head". Blood became a principal cast member in the second season, starting with "Shadows". His ex-wife is Agent Morse, who persuaded Coulson to let Lance join S.H.I.E.L.D.
A S.H.I.E.L.D. agent who goes undercover as the head of security at Hydra Laboratories. She is also Lance Hunter's ex-wife and persuaded Phil Coulson to recruit him to his team. Palicki was upgraded to a principal cast member in the episode "Aftershocks".
A S.H.I.E.L.D. agent working under Garrett who specializes in combat/weapons. Triplett joins Coulson's team after Garrett is exposed as a Hydra agent. He is killed in "What They Become" by a shard of the Obelisk after trying to save Skye.
An elite member of Hydra since 1945 who is able to live up to the present day, obsessed with obtaining the Obelisk. While he usually uses others to do his work, including those he has brainwashed, Whitehall makes some exceptions that need his personal attention. In "The Things We Bury", it is revealed that Daniel Whitehall maintained his young appearance by using the DNA and organs of a woman who was immune to the Obelisk and was the wife of Calvin Zabo. He is later shot by Phil Coulson in "What They Become" depriving Calvin of his revenge.
A Hydra agent who is the right hand man of Daniel Whitehall. He ends up in S.H.I.E.L.D. custody after being left for them by Grant Ward in "The Writing on the Wall". In the same episode, it was revealed that Sunil Bakshi worked with Daniel Whitehall while Baron Strucker was operating in Europe.
Skye's father who is an unidentified monster known as "The Doctor". He later allies with Daniel Whitehall in "A Hen in the Wolf House" in order to deal with Phil Coulson who he blames for keeping Skye away from him, but also secretly seeks revenge against Whitehall for the death of his wife. In "What They Become", his real name is revealed to be Calvin Zabo.
An elite member of Project Centipede, serving as its recruiter. She was arrested by S.H.I.E.L.D. in "The Magical Place" and later sprung from prison by Grant Ward in "Providence". Though she continues to assist Garrett before his death, Raina does not share Hydra's ideals as she aligned herself with Skye's father and gave him the Obelisk. In "Ye Who Enter Here" and "What They Become", revealing herself to be among a special group of people designated by the alien Kree race, Raina uses the Diviner to unlock her true potential as an Inhuman alongside Skye. However, she is horrified that her Terrigenesis turned her into a thorn-covered creature and is later taken in by Gordon.
118 – "Providence" (Eric)
122 – "Beginning of the End" (Billy)
209 – "...Ye Who Enter Here" (Sam)
1 • 2
S.H.I.E.L.D. agents stationed at secret bases, with Billy stationed at the Playground and Eric stationed at Providence. Eric is killed by Grant Ward in "The Only Light in the Darkness" while his brother Billy assists Coulson in the rebuilding of S.H.I.E.L.D. Oswalt also plays Sam Koenig in the second season episode "...Ye Who Enter Here", where he and Billy work to rescue Raina from Hydra operatives.
A high-level S.H.I.E.L.D. agent/munitions expert who is a former cohort of Coulson and works alongside Ward and May. He is revealed to be a high-ranking member of Hydra and the "Clairvoyant", the mastermind behind Project Centipede, in "Turn, Turn, Turn", and the first test subject of the Deathlok program in "Ragtag". He is killed by Coulson in "Beginning of the End".
An ordinary man that was artificially enhanced with the Extremis-containing Centipede serum by Project Centipede, Peterson later joins S.H.I.E.L.D. and falls under the control of the "Clairvoyant" after losing his right leg, which was replaced with a bionic prosthetic as part of "Project Deathlok". In "Beginning of the End", he rebels against Garrett with Skye's help and leaves to seek redemption for his crimes as Deathlok.
A S.H.I.E.L.D. agent who is brainwashed by Daniel Whitehall into serving him. She wears a Photostatic Veil with the likeness of Agent May which was damaged following a fight with her in "Face My Enemy" which she has not yet removed. After Daniel Whitehall was killed by Phil Coulson in "What They Become", Agent 33 escapes with Grant Ward. In the same episode, it is revealed that Agent 33 is only loyal to Daniel Whitehall and not Hydra.
Stojan portrayed the character before she took the likeness of Agent May, at which point Wen portrayed the character.
The following is a supplementary list of recurring guest stars that appear in lesser roles or make significant cameo appearances. The characters are listed, in alphabetical order by actor, by the media or season in which they first appeared.
Jaimie Alexander as Sif: An Asgardian warrior and Thor's childhood friend, based on the mythological deity of the same name. Alexander first appears in season 1 and will appear again in season 2.
Hayley Atwell as Peggy Carter: An officer with the Strategic Scientific Reserve and a co-founder of S.H.I.E.L.D. Atwell first appears in season 2.
The former Director of S.H.I.E.L.D., and former supervising officer to Coulson and Garrett in their early days. He appoints Coulson as the new Director of S.H.I.E.L.D. in "Beginning of the End". Jackson first appears in season 1.
Daniels has the ability to drain the energy out of anything around him, following an experiment with the Darkforce. He was incarcerated in the Fridge until he was freed during John Garrett's raid. He exploded when Coulson and Triplett shined their pure light devices on him in "The Only Light in the Darkness".
Imelda Corcoran as Dr. Goodman: A S.H.I.E.L.D. physician who worked on Project T.A.H.I.T.I. under Coulson and participated in his resurrection.
Cullen Douglas as Edison Po: An elite member of Project Centipede with connections to the "Clairvoyant". He was later killed through his phone by the "Clairvoyant".
Brad Dourif as Thomas Nash: A vegetative man who was used by John Garrett to make Coulson's team think he was the Clairvoyant. He is killed by Grant Ward.
Ron Glass as Dr. Streiten: A S.H.I.E.L.D. physician who had overseen Coulson's resurrection.
Ian Hart as Dr. Franklin Hall: A former S.H.I.E.L.D. researcher and teacher of Fitz and Simmons who can manipulate gravity with his "gravitonium" generator that was created by Ian Quinn.
Shannon Lucio as Dr. Debbie: A scientist working for Project Centipede that worked on Mike Peterson as revealed in the "Pilot" episode. She is later incinerated by Chan Ho Yin in "The Girl in the Flower Dress."
Dylan Minnette as Donnie Gill: A cadet at the S.H.I.E.L.D. Academy of Science and Technology who created a weather-controlling device. After an incident with the device, he received cryokinetic abilities.
A MassachusettsSenator who is the manipulative and sadistic older brother of Grant Ward, who had previously abused Grant and their younger brother Thomas. He is seemingly murdered along with his parents by Grant in "The Things We Bury", with the death being covered up to look like a murder-suicide.
Drea de Matteo as Karla Faye Gideon: A woman with gifts and a grudge against S.H.I.E.L.D. who allies with Calvin.
Jaimie Harris as Gordon: An eyeless Inhuman with the ability to teleport. His transition to an Inhuman was tended to by Jiaying.
A whip-wielding, Hydra-aligned mercenary who leads other agents posing as S.H.I.E.L.D. agents to discredit S.H.I.E.L.D. He is defeated by Melinda May and arrested alongside his fellow operatives by Talbot.
Dichen Lachman as Jiaying: Skye's mother and the wife of Cal, revealed to be an Inhuman that never ages. She helps guide newly created Inhumans in using their gifts. Jiaying is murdered by Daniel Whitehall, who experiments on her to discover her secret.
Lucy Lawless as Isabelle "Izzy" Hartley: A S.H.I.E.L.D. agent. She is killed by Creel in "Shadows".
A Hydra operative recruited by Garrett working for Whitehall, who can absorb the properties of whatever he touches. Creel is captured by Coulson's team and placed in Talbot's custody in "Heavy Is the Head".