Voice actor George Lowe has made several appearances throughout the series' run as a guest star before entering into the main cast. Lowe went on to serve as the announcer during the eighth season. The season two finale "The Last One" featured several guest appearances from previous guest stars reprising their roles from the first two seasons. To date "The Last One" features more guest appearances than any other episode in the series. The guest stars in the season five episode "Bible Fruit" reprised there roles for a spin-off series based on the episode.
Several episodes of Aqua Teen Hunger Force feature guest appearances from others outside of the main cast, a similar practice was used in Space Ghost Coast to Coast. Most guest appearances are comedians however others including professional athletes such as Bart Oates and John Kruk or musicians such as Chuck D, T-Pain, Chickenfoot and Insane Clown Posse.
Voice over artist George Lowe, has made several appearances throughout the series run. Lowe made his first appearance in Aqua Teen Hunger Force in the season one episode "Mail-Order bride" and would go on to make several other cameos since. Lowe had a prominent appearance as himself in the season four episode "Antenna", and reprised his role as Space Ghost for a quick appearance in Aqua Teen Hunger Force Colon Movie Film for Theaters. Lowe was later considered a member of the main cast in 2011 during Aqua Unit Patrol Squad 1, where he announced the title for each episode and continued to make cameos.
David Cross, H. Jon Benjamin, and Kristen Schaal all appeared in the season five episode "Bible Fruit". The episode eventually lead to a spin off series entitled Soul Quest Overdrive which featured all of the guest stars from "Bible Fruit". Six episodes of Soul Quest Overdrive were produced and four of them were aired as part of Adult Swim's "DVR Theater" on May 25, 2011. The series has been cancelled and has never been aired since, leaving two episodes left unaired.
Several guest appearances from the first two seasons reprised their roles in the season two finale "The Last One". "The Last One" features more guest appearances from any episode of the series so far. As a running gag, most of the celebrity guest voices are credited under fake names in the closing credits.
Comedian Patton Oswalt voiced both of the aliens in "Frat Aliens" and later reprised both roles in "The Last One", and then once again for the 2007 video game Aqua Teen Hunger Force Zombie Ninja Pro-Am. Oswalt would later return to voice Ezekiel in the season four episode "Ezekiel".
Several guest stars who appeared during the shows first two seasons returned to reprise their roles in the season two finale, "The Last One", which features the returns of several minor characters.
Musician Brendon Small was credited as "Dick Small" in the original airing of "Dickesode". This was part of a gag featured in the episode were the first name of person in the credits was changed to "Dick".
Comedian Paul F. Tompkins made an appearance in the uniared episode "Boston" which was meant to air in season five. Dave Willis later called him an "Amazing comedian" and later returned for the season seven episode "Juggalo".
H. Jon Benjamin (left) and David Long Jr. during their live action appearance in "Last Last One Forever and Ever". The episode also features other live action appearances from T-Pain and Drake E. Stephens. Long had originally gotten the part in the episode after winning a contest with Burger King.
From the left: Michael Anthony, Joe Satriani, Sammy Hagar, Chad Smith of the band Chickenfoot voiced themselves in "IAMAPOD". Their song "Bigfoot" was later featured in the season eight episode "The Last Dance for Napkin Lad".