List of Ebola outbreaks

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"Ebola outbreak" and "Ebola epidemic" redirect here. For the most severe current outbreak, see Ebola virus epidemic in West Africa.

The International Committee on Taxonomy of Viruses currently recognizes five ebolaviruses: Ebola virus (EBOV), Sudan virus (SUDV), Reston virus (RESTV), Taï Forest virus (TAFV), and Bundibugyo virus (BDBV).[1][2][3][4][5][6] Four of these viruses are known to cause Ebola virus disease (EVD) in humans, and the fifth, RESTV, has caused EVD in other primates.[7][8]

Transmission between natural reservoirs and humans is rare, and outbreaks of Ebola virus disease are often traceable to a single case where an individual has handled the carcass of a gorilla, chimpanzee, or duiker.[9] The virus then spreads person-to-person, especially within families, hospitals, and during some mortuary rituals where contact among individuals becomes more likely.[10] Before outbreaks are confirmed in areas of weak surveillance on the local or regional levels, Ebola is often mistaken for malaria, typhoid fever, dysentery, influenza, or various bacterial infections which may be endemic to the region. Learning from failed responses, such as that to the 2000 Uganda outbreak, public health measures including the WHO's Global Outbreak and Response Network were instituted in areas at high risk. Field laboratories were established in order to confirm cases, instead of shipping samples to South Africa.[11] Outbreaks are closely followed by the United States Centers for Disease Control and Prevention (Special Pathogens Branch) as well.[12]

List of outbreaks[edit]

Year Country Virus Human cases Human deaths Case fatality rate Description
1976  Sudan SUDV 284 151 53% Occurred in Nzara, Maridi and surrounding areas between June and November 1976.[13] Mainly spread by personal contact in hospitals. Many medical care personnel were infected.[14]
1976  Zaire EBOV 318 280 88% Occurred in Yambuku and surrounding areas in August. Spread by personal contact and use of contaminated needles and syringes in hospitals/clinics.[15]
1976  United Kingdom SUDV or EBOV[note 1] 1 0 N/A Laboratory infection by accidental stick of contaminated needle.[16][17]
1977  Zaire EBOV 1 1 100% Noted retroactively in the village of Tandala.[17][18][19][20]
1979  Sudan SUDV 34 22 65% Occurred in Nzara, Maridi. Recurrent outbreak at the same site as the 1976 Sudan epidemic.[21]
1989–1990  Philippines RESTV 3[note 2] 0 N/A High mortality among crab-eating macaques in a primate facility responsible for exporting animals in the USA.[22] Three workers in the facility developed antibodies but did not get sick.[23]
1989  United States RESTV 0 0 N/A RESTV was introduced into quarantine facilities in Virginia and Pennsylvania by monkeys imported from the Philippines. No human cases.[24]
1990  United States RESTV 4[note 3] 0 N/A RESTV was introduced into quarantine facilities in Virginia and Texas by monkeys imported from the Philippines. Four humans developed antibodies but did not get sick.[25]
1992  Italy RESTV 0 0 N/A RESTV was introduced into quarantine facilities in Siena by monkeys imported from the same facility in the Philippines as the 1989 and 1990 US outbreaks. No human cases.[26]
1994  Gabon EBOV 52 31 60% Occurred in Mékouka and other gold-mining camps deep in the rain forest. Thought to be yellow fever until 1995.[27]
1994  Côte d'Ivoire[note 4] TAFV 1 0 N/A First and thus far only recognition of TAFV. Approximately one week after conducting necropsies on infected western chimpanzees in Taï National Park, a scientist contracted the virus and developed symptoms similar to those of dengue fever. She was discharged from a Swiss hospital two weeks later, and fully recovered after six weeks.[28]
1995  Zaire EBOV 315 254 81% Occurred in Kikwit and surrounding areas. Traced to index case-patient who worked in forest adjoining the city. Epidemic spread through families and hospitals.[29]
1996  Gabon EBOV 37 21 57% Occurred in Mayibout area between January and April. A chimpanzee found dead in the forest was eaten by people hunting for food. Nineteen people who were involved in the butchery of the animal became ill; other cases occurred in family members.[27]
1996–1997  Gabon EBOV 60 45 75% Occurred in Booué area with transport of patients to Libreville between July 1996 and January 1997. Index case-patient was a hunter who lived in a forest camp. Disease was spread by close contact with infected persons. A dead chimpanzee found in the forest at the time was determined to be infected.[27]
1996  South Africa EBOV 2 1 N/A A medical professional traveled from Gabon to Johannesburg, South Africa, in October 1996 after having treated Ebola virus-infected patients. He was hospitalized, and the nurse that took care of him became infected and died.[30]
1996  United States RESTV 0 0 N/A RESTV was introduced into a quarantine facility in Texas by monkeys imported from the same facility in the Philippines as the 1989 and 1990 US outbreaks. No human cases.[31]
1996  Philippines RESTV 0 0 N/A RESTV was identified at a monkey export facility in the Philippines. No human cases.[32]
1996  Russia EBOV 1 1 N/A Laboratory contamination.[33]
2000–2001  Uganda SUDV 425 224 53% Occurred in Gulu, Masindi, and Mbarara districts of Uganda. The three greatest risks associated with Sudan virus infection were attending funerals of case-patients, having contact with case-patients in one's family, and providing medical care to case-patients without using adequate personal protective measures.[34]
2001–2002  Gabon
 Republic of the Congo
EBOV 122 96 79% Occurred over the border of Gabon and the Republic of the Congo between October 2001 and July 2002. First reported occurrence of Ebola virus disease in the Republic of the Congo.[35]
2002–2003  Republic of the Congo EBOV 143 128 90% Occurred in the districts of Mbomo and Kéllé in Cuvette Ouest Département between December 2002 and April 2003.[36]
2003  Republic of the Congo EBOV 35 29 83% Occurred in Mbomo and Mbandza villages located in Mbomo district, Cuvette Ouest Département, between November and December.[37]
2004  Sudan SUDV 17 7 41% Occurred in Yambio county in Western Equatoria of southern Sudan. This outbreak was concurrent with an outbreak of measles in the same area, and several suspected EVD cases were later reclassified as measles cases.[38]
2004  Russia EBOV 1 1 N/A Laboratory contamination.[39]
2007  Democratic Republic of the Congo EBOV 264 187 71% Occurred in Kasai-Occidental Province. The outbreak was declared over on November 20. Last confirmed case on October 4 and last death on October 10.[40]
2007–2008  Uganda BDBV 149 37 25% First recognition of BDBV. Occurred in Bundibugyo District in western Uganda between December 2007 and January 2008[2][3][4]
2008  Philippines RESTV 6[note 5] 0 N/A First recognition of RESTV in pigs. Strain closely similar to earlier strains. Occurred in November. Six workers from the pig farm and slaughterhouse developed antibodies but did not become sick.[41][42]
2008–2009  Democratic Republic of the Congo EBOV 32 14 45% Occurred in the Mweka and Luebo health zones of the Province of Kasai-Occidental between December 2008 and February 2009[43]
2012  Uganda SUDV 24 17 71% Occurred in the Kibaale District between June and August.[44]
2012  Democratic Republic of the Congo BDBV 77 36 47% Occurred in Province Orientale between June and November.[45][46]
2013–present Widespread:
 Liberia
 Sierra Leone
 Guinea
Limited and local:
 Nigeria
 Mali
 United States
 Senegal
 Spain
EBOV 18,757[47][48][49] 7,347 71%[note 6] The most severe Ebola outbreak recorded in regards to both the number of human cases and fatalities began in Guéckédou, Guinea, in December 2013, and spread abroad where it is still ongoing.[51][52][53]
2014  Democratic Republic of the Congo EBOV 66[54] 49[54] 65% Occurred in Equateur Province. Outbreak detected 24 August and according to the WHO, as of 28 October 2014 twenty days had passed since the last reported case was discharged and no new contacts were being followed.[55][54] Declared over on 15 November 2014.[56]

[57]

See also[edit]

Notes[edit]

  1. ^ The Centers for Disease Control chronology notes this infection as "Sudan virus", whereas the 1977 British Medical Journal (BMJ) article refers to it as "Ebola virus". In 1977, there was not yet a distinction between different ebolaviruses. The BMJ article only notes that the patient received "convalescent serum from the Sudan" following similar serum from Zaire.
  2. ^ All three cases were asymptomatic.
  3. ^ All four cases were asymptomatic.
  4. ^ The single Ivorian case was repatriated to Switzerland for medical treatment.[28]
  5. ^ All six cases were asymptomatic.
  6. ^ The estimated case fatality rate for this ongoing epidemic differs from the number of deaths divided by the number of cases due to the estimation method used. Current infections have not run their course, and the estimate may be poor if reporting is biased towards severe cases.[50]

References[edit]

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