There have been 20 head coaches for the Colts franchise. Keith Molesworth became the first coach of the Baltimore Colts in 1953, but he was reassigned to a different position with the team following the season. In terms of tenure, Weeb Ewbank has led the team for more games (112) and more complete seasons (nine) than any other head coach. He led the team to two of their NFL championships. Three Colts head coaches; Ewbank, Shula (3), and Marchibroda, have been named coach of the year by at least one major news organization. Ewbank and Shula are members of the Pro Football Hall of Fame, having been inducted in 1978 and 1997 respectively.
Six times in Colts history there were interim head coaches. In 1972, Don McCafferty was fired five games into the season.John Sandusky was named as the interim head coach for the rest of the season, during which he led the Colts to a 4–5 record, but he was not made the permanent coach the next year. In 1974, head coach Howard Schnellenberger started off the season 0–3 and was fired. Joe Thomas assumed the duties of head coach and finished the season at 2–12. In 1991, the Colts started off 0–5 and Ron Meyer was fired as head coach. Rick Venturi was named as the interim for the final 11 games. In 2005 Tony Dungy was forced to miss one game due to personal issues. Jim Caldwell was named as the one game interim. In 2012 offensive coordinator Bruce Arians was named as the interim head coach indefinitely after Chuck Pagano was diagnosed with leukemia four weeks into the 2012 NFL season.