South Africa have played 28 Twenty20 Internationals under four different captains. In 2009, South Africa were one of eight teams which competed in the inaugural ICC Women's World Twenty20 held in England, but failed to progress beyond the group stage. They played their first home match during the 2009–10 season, hosting West Indies for three matches as part of a larger tour. South Africa's first victory in Twenty20 International cricket came against Ireland in August 2008.Trisha Chetty is South Africa's all-time leading run-scorer with 427 runs. Shandre Fritz is the only South African women to have scored a century in a Twenty20 International, scoring the highest total in any women's Twenty20 International when she scored 116 not out against the Netherlands.Sunette Loubser and Shabnim Ismail are South Africa's leading wicket-takers with 19 wickets.
Since the team was formed, 30 women have represented South Africa in Twenty20 International cricket. This list includes all players who have played at least one Twenty20 International match and is initially arranged in the order of debut appearance. Where more than one player won their first cap in the same match, those players are initially listed alphabetically by last name at the time of debut.