List of The Powerpuff Girls characters
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The Powerpuff Girls 
Blossom (voiced by Cathy Cavadini) is "the smart one" and self-proclaimed leader of the Powerpuff Girls. Her personality is "everything nice", her signature color is pink, and she has long red hair with a large red bow and a pink heart hair clip in the back. She was named for having spoken freely and honestly to the Professor shortly after her creation. She is often seen as the most mature, level-headed and composed member of the group. In the episode "Ice Sore", she showed the ability to blow icicles (and in the end of the episode, blow fire). However, even though Blossom said her ice breath was "all used up", she has been seen using it frequently in the later episodes. She can give into temptation, as seen in the episode "A Very Special Blossom".
Bubbles (voiced by Tara Strong in the series and by Kath Soucie in the What a Cartoon! and my little pony episodes) is "the cute one". Her personality is "sugar", her signature color is light blue, and she has blond hair worn in pigtails. She was named for her cute and bubbly personality, as revealed when she giggled after the Professor named Blossom. Her best friend is a stuffed octopus doll she calls "Octi"(who turns evil in one episode). She exhibits the ability to both understand and speak foreign languages (Japanese, Spanish), as she can read and understand Japanese manga and understand people who speak Spanish. Bubbles can also communicate with various animals (cats, squirrels and even monsters). However, the episodes "Super Zeroes" and "Nuthin' Special" illustrate that in the above respective languages she uses a word for word translation rather than the thought-for-thought method of people more fluent in foreign languages. She also shows the ability to emit a sonic scream (in the episode "Hot Air Buffoon"). Bubbles can also can spit fire as seen in the episode "Simian Says". She will always stand up for (and cuddle with) animals except cockroaches, which she (along with her sisters) finds "icky". She displays and is defined by innocence, playfulness and gentle demeanor, having a tendency to be naive, ditzy, submissive, timid and sensitive. Bubbles' naivety has been used on two separate occasions by Him. At times she can be dim-witted and a bit of a loud-mouth. In the episode "The Boys are Back in Town" she expressed a slight crush on Boomer. Craig McCracken stated in a World Priemere Toons interview that she is the "little more air-headed one". Also, in one episode, she says she hates to see her sisters fight.
Buttercup (voiced by Elizabeth Daily) is the tomboy of the Powerpuff Girls. Her personality is "spice", her signature color is light green, and her hair is short and black in a flip. She frowned and pouted when the Professor named her simply because, like her previously-named sisters, her name "also starts with B". She can be hard to agree with to Bubbles and Blossom at times, but is the toughest fighter of the Powerpuff Girls, not only because of her "spice" side but because, as revealed in one episode, the reason why Buttercup tries her hardest to defeat whichever antagonists she must is because of her green blanket. Buttercup can be the most surly Powerpuff Girl at times, but is practically fearless, loyal, quick-witted and willing to fight. Buttercup can be selfish at times, as revealed in one episode when the Powerpuff Girls started working for silver dollar allowances and Buttercup became fascinated by silver dollars, but soon discovered that she could obtain more by knocking out criminals' teeth and leaving the teeth for the Tooth Fairy. She is shown to be fairly protective of her sisters, though, and will not hesitate to confront anybody who speaks badly of them, such as in the episode "The Boys Are Back in Town" when she unwittingly discovers the Rowdyruff Boys' weakness after hitting Butch's tongue, who was laughing at Bubbles after putting a slug down the back of her dress while in sort of an unconscious state. She is often reckless, but can be fairly witty at times, and she is frequently sarcastic. Also, she may be stronger than her other sisters, as revealed in the episode "Octi Evil" when she throws a monster rolled up in a ball to Blossom, which goes through various buildings. She also has desires to be the leader instead of Blossom (revealed in "Octi Evil"). Craig McCracken stated in a World Priemere Toons interview that she is "the real quiet but real tough one".
Citizens of Townsville 
Professor Utonium 
Professor Utonium (voiced by Tom Kane) is a brilliant scientist who works in his home in the suburbs of Townsville. A stereotypical scientist, his general attire is a white lab coat and black pants with pens tucked into the lab coat's breast pocket. The Professor once housed a chimpanzee named Jojo (later to become the girls' arch-enemy, Mojo Jojo) as a lab assistant who proved to be reckless and destructive. Jojo pushed the Professor while he was stirring his Perfect Girl concoction, causing him to accidentally break through a glass containing the mysterious "Chemical X" which spilled into the formula, thus creating the Powerpuff Girls. The Professor is a genius in many fields of science, having shown knowledge in fields such as physics, chemistry, and biology as well as being a skilled inventor (inventing things such as a giant bipedal Powerpuff mech called the DyNaMo and a super suit that allowed him to fight crime with the girls). Aside from his role as a scientist, he acts as parent in The Powerpuff Girls' lives (doing things a father would normally perform, like preparing their school lunches or cheering up his "daughters" when they've been hurt). Although the girls address him as "Professor", when discussing the Prof with others, they refer to him as "our dad" (and Bubbles called him "dad" when he had given her Octi as her birthday present). The Professor can be odd, silly, clumsy, easily manipulated and over-protective at times, but still retains his caring father figure image. His catchphrase is "I made it!" which is seen in such episodes and specials "Uh Oh Dynamo" and "Powerpuff Girls Rule". He drives a Studebaker Avanti.
The Mayor of Townsville 
The Mayor of Townsville (voiced by Tom Kenny in the series and by Jim Cummings in the What a Cartoon! episodes) is generally referred throughout only as "Mayor", although he is referred to as "Barney" by his wife in the episode "Boogie Frights". He is short and old with a fringe of white hair around a bald scalp, and a thick mustache. He wears a monocle over his left eye and a small top hat that floats just above his head. He also has a love for pickles. The Mayor is dimwitted but loves his city. In the episode "Night Mayor", was having nightmares and so had the Powerpuff Girls try to help him in the dream through an invention of the Professor's. In the dream, the Mayor is tall, handsome, has hair and fights crime by himself. All the people of Townsville (even the women) have his old face and the buildings are made of pickles. The Mayor is very childish at times, such as in the episode "That's Not My Baby" where he complains in a childish voice to Miss Bellum, asking why they cannot name Main Street after him. In the episode "Octi Gone", it was shown that he fought with Bubbles, wanting Octi for himself. In episode "Toast Of The Town", when the Professor would not fix his toaster, the Mayor ate several cases of Chemical X and grew to an enormous height. Throwing his tantrum across the city, the Mayor finally agreed to take antidote X when the professor fixed his toaster. However, after he shrank, the Mayor was then stuck at the top of a skycraper. In episode "Meat Fuzzy Lumpkins" featured a different Mayor who was younger and taller than the Mayor of the series. He also is to call the girls for very silly reasons (as revealed in the episode "Bubblevicous" when he calls because of a traffic jam). In (Octi Gone) Bubbles calls Mayor a big baby and he acts like child.
Ms. Sara Bellum 
Ms. Sara Bellum (voiced by Jennifer Martin): The Mayor's very competent, statuesque, and redhead right-hand assistant who often handles the things the Mayor cannot. She wears a red dress, and red high heel shoes for a secretary look. Her face is usually not revealed onscreen, but there have been exceptions to this in several episodes. In some cases, her face has been "shown", after having first been replaced by some alternate form (like in the episode "Monkey See, Doggie Do", where she was transformed into a dog, and in the episode "Something's a Ms.", where she was dressed like Sedusa and wore a Sedusa mask). In the 10th anniversary special of the show, "The Powerpuff Girls Rule!!!", half of her face (with hair still covering part of its right side) was actually shown for a fraction of a second. Most of the time when she is visible on screen, her face is either blocked by some obstruction, by her own hair, or by a camera position to omit everything from the neck up when her lower body is shown. This has sometimes led to her neck appearing abnormally long for a human. Other onscreen characters often claim that she is very beautiful, with the exception of the abrasive Talking Dog. She is named after the cerebellum, probably in reference to her job as the "brains" of the mayor's operation. She attended high school with Sedusa and Femme Fatale prior to the Powerpuff Girls' creation. She has also helped the girls defeat the Rowdyruff Boys in the episode "The Rowdyruff Boys", where she advised the girls to "instead of fighting, try being nice" (in other words, kiss them) to destroy them, which ended up working. She made a cameo in an episode of Chowder, in which it is implied she is to be the police chief's blind date.
Ms. Keane 
Ms. Keane (voiced by Jennifer Hale in the series and by Kath Soucie in the What a Cartoon! episodes): The kindergarten teacher of Pokey Oaks Kindergarten. She wears an orange shirt, red vest, brown pants, and has short black hair and light blue eyes. She is patient, understanding and very protective of her students, making her a well-liked, motherly figure. She, once upon a time, fell in love with the Professor and went on a date with him in episode "Keen on Keane", but their passion was unfortunately short lived when the Professor found out that Ms. Keane had a cat, since he had a traumatic experience with one in a previous episode as it made him jump off a building.
It should be noted that although Ms. Keane is a kindergarten teacher, she is also incredibly smart. This was shown in the episode "Speed Demon" when she, prior to the girls' time travel, actually tried to figure out how the speed of a person throwing an apple could make said apple travel faster than the speed of light and thus being able to travel though time and space. Soon realizing that she is confusing the children, she returns to her normal state, and excuses herself. Ms. Keane also forbids any fighting in school even if there's a crisis taking place within it thus she convinces the girls that there are other ways to solve problems other than fighting as demonstrated in the episode "Schoolhouse Rocked".
Narrator (voiced by Tom Kenny in the series and by Ernie Anderson in the What a Cartoon! episodes): The enthusiastic but unseen narrator, known for opening nearly every episode with "The City of Townsville"! and ending most of them with "So once again, the day is saved, thanks to... the Powerpuff Girls"! He will often comment on the proceedings of the episode, say things which happen to be hints about the plots of certain episodes, and frequently breaks the fourth wall. He is only seen at one point in the series (in the episode "A Made Up Story" he wakes up the mayor who is sleeping under the podium. Viewers see only his hand and part of his arm), though he is a person and not just a disembodied voice. He is also shown to be the only connection between the audience and the girls, as he can "talk" to both and even be involved, such as Mojo Jojo transforming him into a dog. In the episode "Simian Says", he is kidnapped by Mojo Jojo, who promptly takes his place as the episode begins, granting Mojo Jojo the power to narrate the story as he sees fit; the girls have no choice but to go along with the narrative until they accidentally find him dictating the story's events, suggesting that the Narrator has absolute power over the story, though he never seems to exercise it himself. In The Powerpuff Girls Movie, he creates the "Powerpuff Girls" title for the girls when they become the city's protectors. At the end of the episode "Criss Cross Crisis", he and Bubbles temporarily switch bodies.
Talking Dog 
Talking Dog (voiced by Tom Kane in the series and by Paul Mercier in the What a Cartoon! episodes): A small white dog with black ears and nose and a black spot on his back, wearing a red collar with a yellow dog tag. He mostly appears as a background character, but always has something to say. In the episode "Shut the Pup Up", he was taken in by the Girls when he became the sole witness to a mystery crime. When he stays with the girls he is shown to be blunt, abrasive and insulting in that episode, though his demeanor remains straightforward and earnest. In "Mo Linguish" he was the only one in the city whose English was good enough to reverse Mojo Jojo's language lessons. If one watches The Powerpuff Girls Movie before any other episode (since it serves as a prequel to the series), the first thing he says is "Thank you." which he says after the girls save the town from Mojo Jojo for the first time, and after Buttercup (reluctantly) takes the time to save him several times in a row. He is frequently abused in almost every appearance he makes, but, as a running gag, no one ever seems to regard his pain and simply ignore him. Most of the time these incidents are caused by the Powerpuff girls accidentally hitting him or crushing him under some object, or villains like Mojo Jojo doing something to him on purpose or by mistake (like pulling off his tail). The only time that the girls seemed to injure him deliberately was when Bubbles was attempting to be hardcore. Talking Dog was driving for some reason, and Bubbles ripped the roof off of his car and punched him repeatedly, sending him skidding on the road. In the episode, "The City of Frownsville", he seems to have visited the girls and Professor, although he has not made further appearances in their house after that. He is also shown to have a little anger over the girls as seen in "Documentary", where he was interviewed by Brian Larsen, he stated that the girls were boring and in "The Powerpuff Girls Rule" he was upset that the girls were fighting over who gets the key to the world as he walks by them saying "I have nothing to say," although he still loves the girls.
Mitch Mitchelson 
Mitchell "Mitch" Mitchelson (voiced by Tom Kenny): The bully at Pokey Oaks Kindergarten. Mitch has brownish hair, and wears a black T-shirt with the words “MITCH ROCKS” on the front. Usually talks in a gruff voice; he torments the kids in the class in a few episodes, though he is not a major threat (strange enough he was actually on Santa's nice list in the Fight Before Christmas). His laugh is almost the same as that of Popeye. He is Buttercup's close friend, according to Buttercup in her interview in the DVD features of The Powerpuff Girls Movie. For a brief time he hosted a short segment on Cartoon Network called "Mitch Rocks", where he looked at or watched various things and said whether they "rock" or not. He lives in a trailer park with his grandma and owns a pet snake. In the episode "Gettin' Twiggy With It", he was allowed to take Twiggy, the class's pet hamster, home with him for the weekend. Mitch subsequently taped her into a remote-controlled car, nearly choked the hamster with treats, and finally, taped her to a remote controlled rocket that he then sent down the toilet, causing Twiggy to come into contact with radioactive waste and, upon reemerging, tried to eat him.
Elmer Sglue 
Elmer Sglue (voiced by Dee Bradley Baker): A boy at Pokey Oaks kindergarten who liked to eat a lot of glue. Because of this, his classmates started tormenting him, except Blossom and Bubbles. When he unknowingly ate glue mixed with toxic waste, he mutated into a giant paste monster and created massive messes in a rampage all over Townsville, enraged from being teased by Buttercup earlier that day. The Powerpuff Girls tried as much as they could to stop the now-monstrous Elmer, but Blossom and Bubbles were both stuck to his chest and instantly lost in the battle, forcing Buttercup to say she was sorry (even though she didn't want to) for picking on him and calling him a "paste eater". With that, Elmer finally calmed down and said, "Thanks, Buttercup. That's all I wanted." He starts to help build pokey oaks kindergarten.He eventually recovers from his mutations and is seen in his human form in later episodes. Elmer Sglue name is reference to the adhesive Elmer's Glue.
Rainbow the Clown (voiced by Tom Kenny) is a fun, cheery, and lovable clown who enjoys going to birthday parties for children, wearing very bright rainbow-colored tights, and singing "Happy Happy Birthday" to whoever's party it was. (He sang for a guy named Jim in the first season's "Mime for a Change".) However, after being doused with bleach gushing from a crashed truck, the chemical changes his outfit to black and white, and also negatively affects his brain, turning him into the color-draining super-villain Mr. Mime. Mr. Mime turns nearly all of the City of Townsville into a colorless world and the people absolutely mute, including Blossom and Buttercup, simply through contact. Bubbles is able to put everything back to its normal, colorful state through music with her and her sisters' hit song, "Love Makes the World Go Round", and Mr. Mime became Rainbow once again. Rainbow is beat up by the Powerpuff Girls and sent to jail, but it appears that his sentence was only short as he later attended the Powerpuff Girls' birthday party, as seen in the episode "Birthday Bash".
Villains of Townsville 
Mojo Jojo 
Mojo Jojo (voiced by Roger L. Jackson), a mad scientist simian with great intelligence, who speaks in a convoluted, repetitive manner. As the main antagonist of the series and the movie, Mojo Jojo was Professor Utonium's reckless lab assistant, Jojo, before Professor Utonium created the Powerpuff Girls. He has green skin, pink whites in his eyes, wears a clay turban of white with three purple upside down V-shaped lines towards the metal purple jeweled base and two purple circles inside each other on both sides at the top, that covers his large, oversized brain caused by the explosion that created the girls, and wears white gloves and boots, a blue suit with a white belt, and a long wavy, purple cape. Despite his high intelligence, he is not good at planning his schemes, and as a result they fall apart. However, he is a master at manipulation and trickery, oftentimes fooling the girls into thinking he's changed despite their constant encounters.
Mojo Jojo was the leader of the group of supervillains known as "the Beat-Alls", which in addition to Mojo Jojo himself, also consisted of Him, Princess Morbucks, and Fuzzy Lumpkins. Initially, the Beat-Alls were thought to be unstoppable, until Mojo Jojo falls in love with a female monkey thought to be named Moko Jono, which Mojo Jojo thought was a performance criminal. Moko Jono proved to be an annoyance to the group, leading to the other three original members of the Beat-Alls going on without Mojo Jojo and Moko Jono. Without their leader, the Beat-Alls were easily defeated by The Powerpuff Girls. After the Beat-Alls were defeated, Mojo Jojo soon discovers that Moko Jono is actually a monkey from the Townsville Zoo named Michelle, who was hired by The Powerpuff Girls and zookeeper Judy to make Mojo Jojo fall in love with her, thus breaking the Beat-Alls up. Mojo Jojo was eventually sent to Townsville jail in a separate cell from the rest of the Beat-Alls.
Fuzzy Lumpkins 
Fuzzy Lumpkins (voiced by Jim Cummings) is a large, husky, furry pink bear-like hillbilly monster with a wide jaw, a green nose, two antennae on his head, big blue overalls and brown countryman shoes. He is the first villain ever to be introduced in the series, appearing in the pilot "Meat Fuzzy Lumpkins" where he turned the people of Townsville into meat after he lost in the jam contest. He also had brief non-speaking cameos in The Powerpuff Girls Movie, once in the beginning of the movie holding up the convenience store with a pink musket, and again at the end in jail with Mojo Jojo and the Ganggreen Gang. He talks with a Southern accent, and will shoot anything he finds trespassing on his property but is otherwise harmless. He lives in the woods next to the city of Townsville. He is also prone to destructive fits of rage, from which he gains enough physical strength to overpower (and sometimes intimidate) the girls. When angry, Fuzzy turns dark red, he grows claws and his teeth turn sharp, while usually they are large and square. Fuzzy was one of the victims of the Ganggreen Gang's prank calls. The Gang told the girls that Fuzzy had gone crazy again, though he was just taking a bath. The girls beat him up, but realized their mistake before flying away because Fuzzy had turned red and muscular. In "Impeach Fuzz", Fuzzy is annoyed by Mayor's speeches for reelection and his order of "shut up" is taken as his campaign stance, winning him the office overnight. Using the Powerpuffs for a bunch of meaningless jobs (catching his pig, washing his clothes and playing in a bluegrass band for his amusement) and having Miss Bellum dress in Daisy Dukes and speak in Texas slang, the girls were able to get the Mayor to fight back for his office when he learned that Fuzzy was wearing his hat. Fuzzy joined the all-villain group "the Beat-Alls", and the teamed up forces enough to take out the Powerpuffs (though Fuzzy always performed the coup de grâce by tossing a rock on them). Fuzzy was quickly refused as a possibility for stealing the Dynamo suit in episode "Live and Let Dynamo", showing that he would have the Dynamo playing the banjo. In episode "Powerpuff Rainy Day Special", Bubbles seems to think that Fuzzy's banjo is magic enough to bring a giant alligator to life, though Blossom says he is not creative enough. Fuzzy was also a victim of Buttercup's tooth beatings. His only friend is a banjo he calls "Joe", although he has three close relations (Furry, Fluffy, and Hairy), three nephews (Buzzy, Wuzzy, and Scuzzy), and several dozen cousins whom heavily resemble him.
Him (voiced by Tom Kane in the series and by Genndy Tartakovsky in the What a Cartoon! episodes) is a mysterious, supernatural, effeminate, immortal, devilish monster. His physical appearance is an amalgamation of sorts with crab-like claws, red skin, pointed ears, a hooked nose, yellow/green eyes and a long, curled beard, wearing makeup, a woman's red jacket and skirt with pink tulle at the collar and hemline, and black, thigh-high, spike-heeled hooker boots. His voice ranges from a high-pitched falsetto to a deep, booming basso profondo.
According to the narrator in Him's first appearance, he is "so evil, so sinister, so horribly vile, that even the utterance of his name strikes fear into the hearts of men". He is shown to feed off the negative emotions of human beings and become powerless when there is little or no negativity in the air. He refers to the other villains as mortals, which further supports the argument that he is the Devil. In fact, in one of The Whoopass Girls shorts from the early 1990s, he is identified as the Devil, but never in the regular series.
Him's plans often consist of manipulating events to either drive the Powerpuff Girls insane or simply drive wedges between them. Him has used Bubbles' naivete against her in the episodes "Octi Evil" and "All Chalked Up". In the episode "Power Noia", he turns the girls' fears against them, but the girls face their fears before facing Him. Him becomes a gigantic mix between reptile, centipede and himself, but the girls beat him down. In the episode "See Me, Feel Me, Gnomey", Him appears among the villains attacking Townsville, materializing in front of a couple. In the episode "Him Diddle Riddle", it is revealed that Him can cook, and runs the Otto Time Restaurant. Him was one of the victims of the Ganggreen Gang's prank calls, but the girls did not pick a fight with him, instead asking if he had done any crimes. Him, who was doing a workout routine, pleasantly said no. Him was the leader of the villains that attacked the Ganggreen Gang for their pranks, initially calling the Mayor's office, and when arriving, zapping the gang with his eyes, whipping Ace against the floor with his claws, and stomping on Grubber's bare foot. Him was also a victim of Buttercup's tooth beatings.
In "Speed Demon", Him is revealed to be the villain who takes over Townsville in the future. Him, feeding on the negative emotions of the citizens, who are now destabilized and live in a post apocalyptic future, transforms into a gigantic, demonic version of himself which towers over the girls and he taunts them with the fact of their time travelling owing to his victory. However, the girls fly off and return things to normal by going back in time.
In "Live and Let Dynamo", Him was considered a possibility as taking over the Dynamo, but was quickly debunked as they realized he'd doll the Dynamo up with makeup and a fluffy scarf.
Princess Morbucks 
Princess Morbucks (voiced by Jennifer Hale) is a spoiled, insecure, rich little girl, whose partially unseen and mostly mute father allows her to finance various evil plots to destroy the Powerpuff Girls. Her supervillain outfit consists of a yellow, Powerpuff-style dress, black gloves and boots, and a tiara. In the episode "Stuck Up, Up, and Away" she is told by Buttercup that she cannot "just buy superpowers", and she retorts, "Oh yeah, tell that to Batman!" Her hatred of the girls stems from her rebuffed attempt to become one of them. She is also the only female villain in the series who is not an adolescent or young adult woman; she is approximately the same age as the Powerpuff Girls. In her first appearance, she was first given a costume and gear by her father, but her arrogant attitude did not ingratiate her with the girls. When she spoiled an easy bank robbery bust (which ended with her as hostage and taped to a bomb, allowing them to escape), she was chewed out by Buttercup. Blossom tried to reason with her and say how dangerous it was, but Princess ran to her father and blamed everything on them. Her father gave her a super powered suit, complete with laser firing crown, electrical blasting hands and super speed. Easily taking down Buttercup and Bubbles, Princess was outsmarted by Blossom and the three girls were able to team up to take her down and destroy the power suit. In the birthday episode, she sends a missile to the girls that is drawn to a target in the present box she sent. In another episode, she had her father buy her Townsville (giving the Mayor a room full of Turkish Delights in exchange) and makes crime legal. However, this makes her mansion ripe for ransacking and, to avoid getting in trouble with her father, she makes crime illegal again to get the girls to find her and her father's valuables. The girls reveal, after they have set Townsville to rights, that they stole the valuables and only give them back when Princess gives the city back to the Mayor. In the episode "Twas the Fight Before Christmas", she becomes one of only five children in the whole world to ever be put on the Permanent Naughty Plaque (as such never get a gift from Santa) because she changed the good list with the naughty (herself being the only naughty child in the world at the time) and using her good status to finally get the powers of a Powerpuff, but Santa realized the lists were fake when the Powerpuffs, who were always saving people were on the bad list). As punishment, Princess is put on the permanent naughty list, tied and gagged and left with a stocking of coal. In the episode "Boy Toys" the Rowdyruff Boys crashed into her car when they were fighting the Powerpuff Girls. She decided this is a perfect opportunity to join a group that has all the powers of the Powerpuff Girls but still be evil. She manages to stop the Powerpuff Girls from defeating the Rowdyruff Boys after they have collapsed in a road and she asks them if she can join, but the Rowdyruff Boys burst out laughing and cruelly reject her, as she's a girl and Princess uses this fact to manipulate the Powerpuff Girls and join forces to defeat the Rowdyruff Boys, although the girls just used Princess' weapons to outwit the boys and at the same time destroy the weapons(which Princess was planning to destroy the girls with originally). It is revealed in episode "Mo Job" that when injected with Chemical X, she is stronger than all three Powerpuff Girls.
The Ganggreen Gang 
The Ganggreen Gang are a gang of five teenage hoodlums that are green-skinned and unhealthy looking. They originally appeared alongside The Amoeba Boys in McCracken's original short, Whoopass Stew, as the villains the girls are shown fighting in the introduction (rather than every major recurring villain on the show). They also cameoed in The Powerpuff Girls Movie as the first villains the girls ever encountered, though the girls were too reluctant to use their powers to do anything about it at the time and were saved by Mojo Jojo. They were, however, beaten up by the girls and sent to prison at the end of the movie. They do not have powers, nor are they truly a threat; however, they do have special characteristics and they did once obtain powers in the episode "Power Lunch". The Ganggreen Gang made crank calls to the girls using the Powerpuff hotline, only for the villains who ended up being the victims of the pranks (Mojo Jojo, Fuzzy Lumpkins, and Him) to beat the Gang senseless. They are also victims of Buttercup's tooth beatings. The episode where they are shown as slightly sympathetic characters is "Aspirations", where Sedusa uses them to gain the power of magical Egyptian artifacts, then throws them aside after saying she loved them all, breaking their hearts. In return for her betrayal, they gave the Powerpuffs the method to defeat Sedusa and refuse to help her again when she is stripped of the magic, with Ace knocking her into a mud hole and leading the gang to play arcade games instead. They are a tribute to the work of cartoonist Ed Roth, particularly Rat Fink.
- Ace Copular (voiced by Jeff Bennett): The Gang's leader, Ace Copular is a mean-spirited, bullying, opportunistic rogue. He sports a slick-back hairdo, a colored vest-jacket, a peach-fuzz mustache, a pair of shades, and also has fangs. As the Gang's smartest member, he is the instigator of most of their antisocial activities, and he does possess a certain charismatic charm that allows him to sweet-talk people who ought to know better, such as Ms. Keane in episode "School House Rocked" and even Buttercup in episode "Buttercrush". He speaks in a nasally Italian New Yorker accent. In episode "Power Lunch", he was given freezing powers that rivaled Blossom's own freeze breath. In the comic "Buttercup and the Mind-Reading Juice" it is revealed that he is aquaphobic, although in Powerpuff Girls Z episode 50 he is seen sitting in a hot tub.
- Snake Ingleberry (voiced by Tom Kenny): A slippery character with a forked tongue, skinny body, and a hissing voice, Snake seems to be the Gang's second-in-command, but he is reduced to a sniveling yes-man to Ace. He does have a personality of his own, but it is usually silenced due to Ace punching him when he speaks out of line (or even asking a question). This could imply that Snake is more loyal to his friend Ace than he is independently evil. It is revealed in episode "School House Rocked" that his real name is Sanford D. Ingleberry. In episode "Power Lunch", he was given the power to stretch. In the English dub of Powerpuff Girls Z he has a female counterpart named Ivy.
- Lil' Arturo (voiced by Tom Kenny and by Carlos Alazraqui in two episodes): A malevolent Mexican midget boy, Lil' Arturo seems to take the most amusement from the Gang's activities. In episode "School House Rocked" he carries around a switchblade-styled comb he calls "Maria", a treasured gift from his incarcerated father. He has a rather prominent underbite. His full name is Arturo de la Guerra, which is Spanish for "Arthur from the War". His accent was more watered down in later episodes, producers fearing complaints of Latino stereotypes. In episode "Power Lunch", he was given the power of super speed.
- Grubber (voiced by Jeff Bennett): The Gang's most physically grotesque member hunchback, barefoot, untidy hair, grubby clothes and protruding eyes, resembling an Ed Roth cartoon, a zombie, a drunk, and Quasimodo from The Hunchback of Notre Dame. He also appears to be mostly mute, communicating instead through blowing a raspberry. He does, however, occasionally demonstrate unexpected talents, such as playing the violin, speaking eloquently or performing impersonations (at first, they were so obvious it was a wonder how he fooled anyone, as in episode "Buttercrush", he simply put on a British accent and was not found out by the naive Bubbles, but later he was able to do them perfectly, such as Miss Bellum). When attending the girls' school for a short time, Grubber showed that he was able to horribly contort his body, making him briefly resemble a well-spoken and handsome looking young man before snapping back to his normal self. In episode "Slave the Day", he is shown to always beat his friends at cards (and devour his winnings). In episode "Power Lunch", he was given the power to belch (sonically).
- Big Billy (voiced by Jeff Bennett): A hulking colossus who acts as the Gang's muscle. Though he does at times display a childlike innocence, he mostly just does the bidding of his more savvy and vindictive friends. In episode "School House Rocked", it is revealed that his real name is William W. Williams and that he is a Cyclops. In "Slave the Day", he was saved by the Powerpuff Girls and began following them everywhere out of sheer gratitude, but eventually he became more of a hindrance than a help, particularly to Blossom. Although he rarely fares any better in combat against the girls than the rest of the gang, he has the muscular power to stop a speeding train from running down citizens from the track and tackle 10-story monsters to the ground with his bare hands. He is also shown to speak in two different ways: like a normal person, and like a caveman. In episode "Power Lunch", Big Billy was transformed into a rock. He is also shown as not very bright, as he could not do a simple prank call easily, even admitting that it was one to the prankee and apologizing.
The Amoeba Boys 
The Amoeba Boys (voiced by Chuck McCann in the series and the What a Cartoon! episodes and by Lou Romano in Whoopass Stew) are a trio of amoebae who are the villains featured in McCracken's original short, Whoopass Stew in A Sticky Situation. They reappear in the What a Cartoon! short Crime 101. With their gangster affectations, these aspiring criminals would love nothing more than to be regarded as serious villains worthy of fighting, and even getting beaten up and sent to jail by the Powerpuff Girls. Unfortunately, their brains are too primitive to devise a crime above the level of littering or jaywalking. Indeed, they considered stealing an orange to be their greatest crime ever in the episode "Divide and Conquer". Ironically, the Amoeba Boys were seen in jail in the Powerpuff's Birthday Bash. The Amoeba boys sent a gift, voodoo dolls to the girls, not understanding that they were supposed to keep the dolls, as well as the needles. They are Townsville's least malicious villains, even having a friendship-of-sorts with the girls. They are generally harmless, but their actions have on occasion endangered both the girls and the town purely by accident. The greatest threat they have posed to Townsville and the girls was in episode "Geshundfight", when they each caught a cold that, when merged with their DNA, created a severe virus that quickly spread through the city, making even the healthiest person fall ill instantaneously. It was not until the girls, who were also infected, acquired their DNA (after a brief and very easy fight, despite the fact they were very sick) so Professor Utonium could create an antidote he soon dispensed to the town, curing them just as quickly. In one episode, they found a plan that Mojo Jojo had made and thought it was a scavenger hunt, with the girls finding the tools for the trap and putting them together, but Mojo took the credit, not wanting to let them have the glory (it resulted in him being sent to jail, but he was still proud of that). The Amoeba Boys finally received the super villain status they had long craved when they used their ability as Amoebas to multiply (since they were trying to figure out how to divide an orange from a heist), creating a veritable army that the girls finally stuck back together. They ended up sending the boys to jail, much to their delight.
- Bossman: The leader and general spokesman of the Amoeba Boys. He wears a gray fedora. In the episode "You Snooze, You Lose" he is shown slapping Junior when he tries to brings things in his mouth that the Powerpuff Girls requested.
- Junior: The smallest one of the Amoeba Boys. He wears a black cap and usually repeats whatever Bossman says. In the episode Crime 101, he is named Tiny. His voice sounds very similar to Curly from The Three Stooges.
- Slim: The tallest one of the Amoeba Boys. He wears a brown fedora and is even much more incompetent and slow than the other amoebas. In the episode Crime 101, he is called Skinny Slim.
Sedusa (voiced by Jennifer Hale) is a young, beautiful mistress of disguise and seductress who uses her feminine wiles to influence men to do her bidding. When her identity is revealed, she typically doffs down to her leotard battle suit and fights with her whip-like hair (which she can control). Femme Fatale referred to her as "That chick in the underwear". In her introduction episode "Mommy Fearest", she poses as an ordinary woman named "Ima Goodlady". She tries to manipulate the Professor against the girls, showing her true colors whenever he was not present and having the girls grounded so she could steal the mayors jewels, but was found out and revealed to the Professor, who she tried to manipulate again, but was unsuccessful. She becomes powerless when her hair becomes wet (or cut off). In episode "Something's a Miss", she poses as Miss Bellum, tying up and gagging the real Miss Bellum at her house(after dressing her up as Sedusa) and seducing the Mayor to perpetrate heists. In this episode, she had the ability to whip off globs of sticky hair gel adhering people to walls, but she was taken down by Miss Bellum, who cut off her hair (though the Mayor still has an interest in dating her). In the episode "Aspirations", Sedusa seduces the Ganggreen Gang into stealing Egyptian artifacts. She is still bald from when Miss Bellum cuts off her hair. When she gets the artifacts, she becomes giant and rather than hair, deadly asps grow from her head. Sedusa betrays the Ganggreen Gang, which leads to Ace telling Blossom to take the crown from Sedusa, which the other artifacts do not work without. Sedusa loses her hair once more, as well as her gigantic stature. She begs the boys to help her, but they refuse and Sedusa is sent back to jail. Her eyes change color. When she is happy or nice her eye color is green, but when she is angry or evil, they are red. This is seen in the episode "Mommy Fearest". She is based on Medusa from Greek mythology.
The Rowdyruff Boys 
The Rowdyruff Boys are the male counterparts of the Powerpuff Girls created by Mojo Jojo using a mixture of "snips, snails, and a puppy dog tail" in the Townsville Prison in the episode called "The Rowdyruff Boys". His replacement for chemical X was in fact prison toilet water (that was glowing), as Mojo Jojo believed that would have the same potency as Chemical X. An important difference between the trios is that the Powerpuff Girls got their names from Professor Utonium and the name of their team from the narrator, while the Rowdyruff Boys named themselves and their team. After their resurrection, the Boys' hairstyles become noticeably spikier, Him claims credit for this in episode "Custody Battle". Their personalities are also more developed where they had once had similar behavior. The Boys wear long-sleeved shirts with a black stripe in each, black trousers and black, low-top converse with white laces and white soles.
- Brick (voiced by Rob Paulsen): Blossom's equivalent, he is the quick-tempered leader of the Rowdyruff Boys. He often goes off on gloating tangents that irritate even his brothers. He has an abrasive and rash attitude, which often causes conflict with his brothers. He wears a red baseball cap compared to Blossom's bow. He also originally had bangs, which were replaced with a long spiky hair down his back when he was revived. After his resurrection, Brick became much more controlling, as seen when he would announce what games the boys would play or his ideas for fighting the Powerpuff Girls. He seems to find Butch's hyperactive, violence amusing as he would always watch his brother's reaction to new 'games'. He also hits Boomer for no reason other than for his own amusement or for saying something stupid. His signature color is red, and his ingredient is "puppy dog tails".
- Boomer (voiced by Rob Paulsen): Bubbles' equivalent, he is a loud-mouthed dimwit, as opposed to Bubbles' naive sweetness and has been known to like disgusting things. After his resurrection, Boomer is implied to be the least intelligent of the boys and he is often the victim of Brick's orders or punishment. Despite being frequently insulted by both of his brothers, he is praised on occasion, like the acknowledgement that he is the best spitter of the group. Boomer's hair parts in a curved fashion like Bubbles' but is longer and spiky on each end, in a wings haircut. His signature color is blue, and his ingredient is "snips".
- Butch (voiced by Roger L. Jackson): Buttercup's equivalent, after his resurrection, Butch becomes more hyperactive or overly excited; he goes wild when Brick calls for a fight or announces a new 'game'. On occasion, he can be much more aggressive than either of his brothers. Butch's hair is spiked upwards (similar to Vegeta's hair), abandoning his previous cowlick from his first appearance. He also shares Buttercup's small triangular hair parting. His signature color is green, and his ingredient is "snails".
The Rowdyruff Boys are essentially violent bullies who have the same powers as the Powerpuff Girls, with their own techniques as well. In their first appearance, they nearly destroy them in a violent clash that reduced a great deal of Townsville to rubble (this is the first and one of the few times the Girls were defeated outright). The Girls were so ashamed of their defeat they planned to leave Townsville until Ms. Bellum suggested using a different tactic. The boys were shocked to find the girls alive but instead of a fight were flirted with. They were ultimately destroyed when the girls kissed them.
The Rowdyruff Boys were later resurrected by Him in the episode "The Boys Are Back in Town". Much to the Girls' shock they were given immunity to the Girls' kisses, which made the Boys grow bigger and more powerful. The Boys eventually got their revenge on the Girls firstly by grossing them out in various ways, such as cracking their knuckles, picking scabs and spitting. The Boys then move on to play violent sports using the Girls as targets. When Buttercup recovers and made Butch bite his tongue, he almost cries with pain and shrinks under his brothers' laughter. Blossom realizes that when their masculinity was threatened, they would shrink and the Girls do various things to embarrass them and shrink them smaller than the buckles of their shoes. Him intervenes and takes the boys back, threatening this would not be the last of them.
In "The City of Clipsville" the Boys make an "appearance" in the memories of the Girls, who remember traveling to the future, becoming teenagers and meeting the teenage Rowdyruff Boys. Instead of a violent confrontation, the boys show a romantic interest in the girls, and each engage in innocent flirting with their counterparts (though the teenage versions of the girls are ditzy and stupid, while the teenage boys seem more in control and composed).
They are last seen as villains in episode "Custody Battle" where Mojo Jojo (their original creator prior to their first deaths) and Him (the one responsible for reviving them) are fighting over who is the more evil father. They both do various crimes to try to prove who is the more evil parent, usually against the Mayor. The Boys are impressed at first but eventually get bored when the fighting degrades to petty arguments. Finally, the boys demand they shut up, and Brick tells them they do not care which one of them is more evil or stupid ("or whatever"). Their final appearance at the end of the episode is when they fly off to destroy the Powerpuff Girls, the only evil thing they ever cared about (which subsequently brings Mojo Jojo and Him to happy tears at having done well as parents).