The Powerpuff Girls: Heroes & Villains: Music Inspired by The Powerpuff Girls was released on July 18, 2000, on CD and audio cassette.The New York Times journalist Ann Powers praised the pop album's original songs, saying, "The precocious sound these bands cultivate has never had a more appropriate niche." Additionally, the album topped Billboard's children's music chart for six weeks upon its debut. Heather Phares of the All Music Guide called the album "appropriately hip and funny" and stated that it is "much more than just a 'music inspired by' marketing piece."
The City of Soundsville: Music from The Powerpuff Girls was released on September 18, 2001, on CD, audio cassette, and vinyl record. Heather Phares of the All Music Guide was quite pleased with the soundtrack, calling it "a complete delight" and "without a doubt one of the coolest children's albums in recent memory."
The Powerpuff Girls: Power Pop was released on June 16, 2003, on CD and audio cassette. Despite positive reviews of the formerly released albums, Allmusic's Heather Phares regarded Power Pop as a "big disappointment", saying "it's especially frustrating that they picked cookie-cutter teen pop for this album when Dexter's Laboratory: Homeboy Genius turned out so brilliantly (and featured hip-hop stars to boot)." Two songs on the soundtrack, "That's What Girls Do" by No Secrets and "Powerpunk End Theme" (originally titled "The Powerpuffs Girls (End Theme)") by Bis were both featured during the end credits of The Powerpuff Girls Movie.