Treehouse of Horror II - In the 1991 Halloween episode of The Simpsons, one of the stories is about how Homer gets a monkey's paw that grants him four wishes. Each member of the Simpson family (except for Marge) makes a wish, which have terrible consequences. In a humorous twist, Homer gladly gives the paw to his neighbor Ned Flanders, only for Ned's wishes to (apparently) go off without any of the usual consequences, causing Homer to grumble "I wish I had a monkey paw."
The Cartoon Network show, I Am Weasel featured an episode in its fourth season entitled "The Baboon's Paw" in which Weasel's sidekick, I.R. Baboon, has the power to make his wishes come true through the use of his own paws, having been told they are lucky after attempting to buy a monkey's paw in Chinatown
Bhusan Dahal's 2008 film Kagbeni is based on the story, but with a few changes made to adjust with the locality.
Five Superb Tales of Horror and the Macabre, 1972, Story Four, "Wish You Were Here" is an adaptation of The Monkey's Claw featuring Richard Greene.
The anime TV series/light novelBakemonogatari story arc, Suruga Monkey, contains an oddity explicitly (albeit incorrectly) believed to be the monkey's paw, with references to its twisted wish-making powers backfiring at the person wishing. However, in contrast to the monkey paw, the wishes are not fulfilled in a way contradicting the intentions of the wish-maker, but actually obeying them.
The 21st episode of the seventh season of the X-Files, Je Souhaite, is a remake of the monkey's paw myth in which Mulder seems to solve the puzzle.
The anime TV series xxxHolic episode 08. It's an episode about Monkey's Paw, an adaptation of the manga.
The K-Horror movie Wishing Stairs recasts the story with the family replaced by a trio of students at an all-girls school and the monkey paw replaced by the eponymous stairs.
The first episode of the second series of the British comedy The League Of Gentlemen contains a reference to the monkeys paw in the shape of a magical toad which when squeezed will grant the squeezer a wish; it is used by the Dentons to wish for their nephews return and a self lowering lavatory seat.
The cartoon series Adventure Time references the concept directly in the second episode of the fifth season, "Jake the Dog," when heroes Finn and Jake meet a wish-granting being named Prismo. Because he likes Jake, Prismo warns that all his wishes have a catch, "like a monkey's paw thing", and helps guide him into making a wish that will only have negative consequences for the villainous Lich.
A spoof in the cartoon series Rick and Morty, season 1 episode 9, "Something Ricked This Way Comes". The monkeys paw is used to save the life of the devil who lost his will to live after he was outwitted by Rick. 
In the mangaxxxHolic, a graduate student studying ancient folklore insists on obtaining the Monkey's Paw even after being told that she is not fated to have it and will suffer horrible consequences if she were to go against fate and use it. She disregards this warning as she firmly believes that bad things only happen to other people. Five wishes (a wish for each finger on the Monkey's Paw) later, she found out too late that she was wrong.
Stephen King's Pet Sematary expands on the theme of bringing the dead back to life, and includes a quote from the Monkey's Paw.
In the book The Dead Zone, by Stephen King, the character John Smith relates his newfound psychic powers to the wishes granted in The Monkey's Paw, realizing that his powers can help people, but they can frighten them away, and that they give him unwanted publicity.
In The Sims 2 for consoles, when a player selects Search Couch while sitting on a sofa, he can find a "Mysterious Zombie Monkey Paw".
In the novel adaptation of 1985 film The Goonies, there is a sequence of spooky stories told by the main characters, and Mouth recalls a story which Stef promptly identifies as The Monkey's Paw. This sequence isn't in the movie.
William S. Burroughs refers to the story in his lecture "Class on the technology and ethic of wishing", warning students to be careful of what they wish for, and discussion its relation to the "Wishing machine" 
In the Piers Anthony novel, A Spell for Chameleon, in Good Magician Humfrey's castle, the main protagonist Bink is shown a monkey's paw by a magic mirror when asking why his magical talent has not been revealed. The Magician then explains that the answers most people seek are of the "monkey's paw variety".