List of largest selling pharmaceutical products

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The following is a list of the top 100 pharmaceutical products ranked by sales in U.S. dollars for Q4 2013.

Rank Brand Name(s) Generic Name Sales Q1 2013 Sales ($000) Change from Q4 2012 Company(ies) Disease/Medical Use First Approval Date Patent Expiration Date[1][2]
1 Abilify Aripiprazole 1,602,329 2.23% Bristol-Myers Squibb, Otsuka Pharmaceutical Psychosis; depression Nov-2002 Oct-2014
2 Nexium Esomeprazole 1,536,435 0.74% AstraZeneca Gastrointestinal disorders Mar-2000 May-2014
3 Humira Adalimumab 1,461,861 3.86% Abbott Laboratories Rheumatoid arthritis Dec-2002 Dec-2016
4 Crestor Rosuvastatin 1,333,502 4.53% AstraZeneca, Shionogi Cholesterol Nov-2002 Jul-2016
5 Advair Diskus, Seretide Fluticasone/salmeterol 1,247,330 2.65% GlaxoSmithKline Asthma Aug-2000 Mar-2012
6 Enbrel Etanercept 1,189,844 1.46% Amgen Rheumatoid arthritis Nov-1998 Oct-2012
7 Cymbalta Duloxetine 1,064,186 -23.06% Eli Lilly and Company Depression; anxiety disorders Aug-2004 Dec-2013
8 Remicade Infliximab 994,020 -2.71% Centocor Ortho Biotech, Inc, Mitsubishi Tanabe Pharma Crohn's disease; rheumatoid arthritis Aug-1998 n/a
9 Neulasta Filgrastim 854,508 -4.90% Amgen Neutropenia Jan-2002 Mon-20XX
10 Copaxone Glatiramer 851,351 -4.69% Sanofi-Aventis, Teva Pharmaceutical Industries Multiple sclerosis Dec-1996 Nov-2014
11 Lantus Solostar Insulin glargine 839,691 9.39% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 Dec-2011
12 Rituxan, MabThera Rituximab 746,766 -0.16% Biogen Idec, Chugai Pharmaceutical, Genentech/Roche Non-Hodgkin’s lymphoma; rheumatoid arthritis Nov-1997 Mon-20XX
13 Spiriva Tiotropium bromide 726,057 3.39% Boehringer Ingelheim Chronic obstructive pulmonary disease Apr-2002 Jul-2018
14 Januvia Sitagliptin 700,941 3.63% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1996 Nov-2017
15 Atripla Emtricitabine/tenofovir/efavirenz 679,418 0.36% Gilead Sciences, Inc. HIV infection Dec-1996 Mar-2015
16 Lantus Insulin glargine 675,461 5.84% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 Dec-2011
17 Avastin Bevacizumab 650,208 -1.25% Genentech/Roche Cancer Feb-2004 Mon-20XX
18 Lyrica Pregabalin 624,774 2.82% Pfizer Neuropathic pain Jul-2004 Jul-2019
19 OxyContin Oxycodone 585,482 -2.91% Purdue Pharma Pain Dec-1996 Mon-20XX
20 Epogen Epoetin alfa 503,493 −2.08% Amgen Anemia Jun-1989 Mon-20XX
21 Celebrex Celecoxib 580,332 5.23% Pfizer Osteoarthritis; rheumatoid arthritis Dec-1998 May-2014
22 Truvada Tenofovir/emtricitabine 542,846 0.03% Gilead Sciences HIV infection Aug-2004 Mon-20XX
23 Diovan Valsartan 533,924 2.80% Novartis Hypertension Dec-1996 Sep-2012
24 Herceptin Trastuzumab 471,387 1.43% Chugai Pharmaceutical, Genentech/Roche Breast cancer Sep-1998 Mon-20XX
25 Namenda Memantine 448,659 −1.32% Forest Laboratories Alzheimer's disease Oct-2003 Apr-2014
26 Gleevec, Glivec Imatinib 438,105 0.41% Novartis Leukemia May-2001 Jan-2015
27 Vyvanse Lisdexamfetamine 430,909 5.48% Shire Attention deficit hyperactivity disorder Dec-1990 Mon-20XX
28 Suboxone Buprenorphine 415,929 −0.32% Reckitt Benckiser Pharmaceuticals Inc. Pain; opioid addiction Aug-2000 Mon-20XX
29 Lucentis Ranibizumab 415,406 4.92% Genentech Macular degeneration Dec-1990 Mon-20XX
30 Synagis Palivizumab 412,703 46.47% MedImmune RSV infection Feb-1998 Aug-2012
31 Zetia Ezetimibe 395,066 5.27% Merck & Co., Schering-Plough Cholesterol Oct-2002 Oct-2017
32 Tamiflu Oseltamivir 392,115 65.38% Chugai Pharmaceutical, Hetero Drugs, Roche Influenza Oct-1999 Mon-20XX
33 Methylphenidate Methylphenidate 383,354 −4.09% Generic Attention deficit hyperactivity disorder Aug-2000 Mon-20XX
34 Symbicort Budesonide/formoterol 376,822 10.70% AstraZeneca Asthma Aug-2000 Mon-20XX
35 OneTouch Ultra 368,604 5.36% Johnson & Johnson Diabetes testing supplies Dec-1990 Mon-20XX
36 Enoxaparin Enoxaparin 365,091 −7.37% Generic Deep-vein thrombosis Mar-1993 Aug-2012
37 AndroGel Testosterone gel 348,205 0.49% Abbott Laboratories, Schering-Plough Low testosterone levels Oct-2002 Oct-2016
38 Lidoderm Lidocaine 345,620 −0.86% Endo Pharmaceuticals Pain Mar-1999 Mon-20XX
39 Avonex Interferon beta 1a 338,236 −9.05% Biogen Idec Multiple sclerosis May-1996 Mon-20XX
40 Levemir Insulin detemir 335,926 8.81% Novo Nordisk Diabetes mellitus type 1 and 2 Dec-1990 Mon-20XX
41 Rebif Interferon beta 1a 332,452 6.61% Serono Multiple sclerosis Feb-1998 Mon-20XX
42 NovoLog Insulin aspart 322,779 3.74% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
43 NovoLog FlexPen Insulin aspart 316,981 7.97% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
44 Seroquel XR Quetiapine 304,400 6.81% AstraZeneca Psychosis; depression Sep-1997 Mar-2012
45 Viagra Sildenafil 288,880 −0.69% Pfizer Erectile dysfunction Mar-1998 Mar-2012
46 Nasonex Mometasone 283,875 8.87% Schering-Plough Allergic rhinitis Oct-1997 Oct-2018
47 Niaspan Niacin 281,011 4.80% Abbott Laboratories Cholesterol Jul-1997 Mon-20XX
48 Humalog Insulin lispro 279,018 8.17% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
49 Alimta Pemetrexed 273,747 −8.17% Eli Lilly and Company Cancer Feb-2004 Mon-20XX
50 Budesonide Budesonide 271,635 2.21% Generic Asthma Aug-2000 Mon-20XX
51 Fenofibrate Fenofibrate 268,473 29.97% Generic Cholesterol Feb-1998 Mon-20XX
52 Lovaza Omega-3 fatty acid ethyl esters 267,926 0.70% GlaxoSmithKline Cholesterol Jun-2001 Mon-20XX
53 Flovent HFA Fluticasone propionate 266,820 −0.67% GlaxoSmithKline Asthma Mar-1996 Mon-20XX
54 Combivent Ipratropium bromide/salbutamol 266,777 0.65% Boehringer Ingelheim Chronic obstructive pulmonary disease Oct-1996 Mon-20XX
55 Amphetamine/dextroamphetamine Amphetamine mixed salts 265,628 −0.69% Generic Attention deficit hyperactivity disorder; narcolepsy Feb-2004 Mon-20XX
56 ProAir HFA Salbutamol 262,338 −7.84% Teva Pharmaceuticals Asthma; chronic obstructive pulmonary disease Oct-1996 Mon-20XX
57 Cialis Tadalafil 253,451 6.81% Eli Lilly and Company, Lilly Icos Erectile dysfunction Nov-2002 Mon-20XX
58 Acetaminophen/hydrocodone Acetaminophen/hydrocodone 251,964 1.58% Generic Pain Aug-2000 Mon-20XX
59 Isentress Raltegravir 243,636 2.00% Merck & Co., Inc. HIV Infection Dec-1998 Mon-20XX
60 Victoza Liraglutide 242,143 6.43% Novo Nordisk Diabetes mellitus type 2 May-1909 Mon-20XX
61 Procrit, Eprex Epoetin alfa 241,175 −2.24% Johnson & Johnson Anemia Dec-1990 Mon-20XX
62 Janumet Sitagliptin/metformin 240,005 7.64% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1998 Mon-20XX
63 Neupogen Filgrastim 239,937 3.86% Amgen Neutropenia Feb-1991 Mon-20XX
64 Reyataz Atazanavir 238,094 0.18% Bristol-Myers Squibb HIV infection Jan-2003 Mon-20XX
65 Restasis Ciclosporin ophthalmic emulsion 237,475 1.89% Allergan, Inc, Lilly Icos Dry eye syndrome Nov-2002 Mon-20XX
66 Metoprolol Metoprolol 236,279 −1.41% Generic Hypertension Jan-1992 Mon-20XX
67 Gilenya fingolimod 235,496 1.18% Novartis Corporation Multiple sclerosis Feb-2000 Jan-2007
68 Incivek Telaprevir 234,084 −12.08% Johnson & Johnson Hepatitis C Dec-1990 Mon-20XX
69 Prezista Darunavir 226,038 4.35% Johnson & Johnson HIV infection Jun-2006 Mon-20XX
70 Vesicare Solifenacin 220,271 5.33% Astellas Pharma US Overactive bladder Feb-2000 Nov-2018
71 Vytorin Ezetimibe/simvastatin 220,100 −0.81% Merck & Co., Schering-Plough Cholesterol Jul-2004 Mon-20XX
72 Hydrochlorothiazide/valsartan Valsartan/hydrochlorothiazide 219,951 0.00% Generic Hypertension Dec-1996 Sep-2012
73 Modafinil Modafinil 218,612 −17.44% Generic Shift work sleep disorder; narcolepsy Dec-1998 Mon-20XX
74 Orencia Abatacept 216,942 2.68% Bristol-Myers Squibb Company Rheumatoid arthritis Aug-2000 Mon-20XX
75 Pradaxa Dabigatran 215,003 4.76% Boehringer Ingelheim, Lilly Icos Oral anticoagulant Oct-2010 Mon-20XX
76 Renvela Sevelamer 210,975 4.77% Genzyme Corporation, Forest Laboratories Hyperphosphatemia Apr-2002 Apr-2016
77 Dexilant Dexlansoprazole 210,005 −0.08% Takeda Pharmaceuticals North America, Inc Gastrointestinal disorders Dec-2004 Jul-2012
78 AcipHex, Pariet Rabeprazole 209,443 −1.84% Eisai, Johnson & Johnson Gastrointestinal disorders Aug-1999 Nov-2013
79 Benicar, Olmetec Olmesartan 204,717 5.92% Daiichi Sankyo, Forest Laboratories Hypertension Apr-2002 Apr-2016
80 Aranesp Darbepoetin alfa 203,664 −1.51% Amgen Inc. Anemia Jun-2001 Mon-20XX
81 Stelara Ustekinumab 201,950 10.71% Johnson & Johnson Psoriasis; psoriatic arthritis Apr-2000 Mon-20XX
82 Humalog KwikPen Insulin lispro 201,646 0.00% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
83 Synthroid Levothyroxine 200,695 5.21% Abbott Laboratories Hypothyroidism May-1999 Mon-20XX
84 Evista Raloxifene 197,559 4.03% Eli Lilly and Company, Chugai Pharmaceutical Osteoporosis Dec-1997 Jan-2013
85 Ventolin HFA Salbutamol 197,453 6.00% GlaxoSmithKline Asthma; chronic obstructive pulmonary disease May-1981 Mon-20XX
86 Adderall XR Amphetamine mixed salts 196,427 −3.21% Shire Attention deficit hyperactivity disorder Oct-2001 Mon-20XX
87 Betaseron, Betaferon Interferon beta 1b 195,574 −3.20% Bayer Multiple sclerosis Jul-1993 Mon-20XX
88 Atorvastatin Atorvastatin 193,260 −1.47% Generic Cholesterol Dec-1996 Nov-2011
89 Doxycycline Doxycycline 193,240 0.00% Generic Bacterial infections Dec-1996 Nov-2011
90 Lunesta Eszopiclone 189,289 −1.43% Sepracor Insomnia Dec-2004 Mon-20XX
91 Fentanyl Fentanyl 189,255 −2.58% Generic Pain Aug-1990 Mon-20XX
92 Zyvox Linezolid 188,084 11.15% Pfizer Bacterial infections Apr-2000 Mon-20XX
93 Xolair Omalizumab 182,221 0.33% Genentech, Novartis Asthma 2003 Mon-20XX
94 Xgeva Denosumab 182,194 4.84% Amgen Osteoporosis Nov-2010 Mon-20XX
95 Prevnar 13 Pneumococcal conjugate vaccine 180,661 −11.69% Wyeth Pneumococcal disease Feb-2000 Jan-2007
96 Sensipar Cinacalcet 180,218 −1.31% Amgen Inc. Hyperparathyroidism Apr-2000 Mon-20XX
97 Xeloda Capecitabine 174,526 −2.21% Chugai Pharmaceutical, Genentech Cancer Jun-1909 Mon-20XX
98 Omeprazole Omeprazole 172,664 0.00% Generic Gastrointestinal disorders Jun-1909 Mon-20XX
99 Focalin XR Dexmethylphenidate 171,147 1.74% Novartis Attention deficit hyperactivity disorder Jun-1909 Mon-20XX
100 Benicar HCT Olmesartan/hydrochlorothiazide 170,433 0.00% Daiichi Sankyo Hypertension Jun-1909 Mon-20XX
101 Actos Pioglitazone 160,000 −41.96% Takeda Pharmaceutical, Eli Lilly and Company Diabetes mellitus type 2 Jul-1999 May-2011
102 Varivax Varicella vaccine 154,000 31.34% Merck & Co., Inc. Chickenpox Dec-1990 Mon-20XX
103 Eloxatin Oxaliplatin 162,000 −55.33% Sanofi-Aventis Cancer Aug-2002 Aug-2016
104 Zostavax Zostavax 158,000 1.17% Eisai, Merck & Co. Herpes zoster Aug-1999 May-2013
105 Gardasil, Silgard Gardasil 153,000 0.00% Merck & Co., Forest Laboratories Human papillomavirus Apr-2002 Apr-2016
106 EpiPen 2-Pak Epinephrine 151,000 0.00% Mylan Specialty L. P. Anaphylaxis Apr-2000 Mon-20XX
107 Velcade Bortezomib 144,000 30.00% Takeda Pharmaceuticals North America, Inc, Lilly Icos Multiple myeloma Nov-2002 Mon-20XX
108 Erbitux Cetuximab 132,000 56.00% Bristol-Myers Squibb, Merck KGaA Cancer Feb-2004 Mon-20XX
109 Protonix, Pantozol, Pantoloc Pantoprazole 130,000 4.00% Wyeth, Altana, Solvay Gastrointestinal disorders Feb-2000 Mon-20XX

Source: http://www.drugs.com/stats/top100/sales, Jun 2013

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