List of largest selling pharmaceutical products

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The following is a list of the top 100 pharmaceutical products ranked by sales in U.S. dollars for Q4 2013.

Rank Brand Name(s) Generic Name Sales Q1 2013 Sales ($000) Change from Q4 2012 Company(ies) Disease/Medical Use First Approval Date Patent Expiration Date[1][2]
1 Abilify Aripiprazole 1,602,329 2.23% Bristol-Myers Squibb, Otsuka Pharmaceutical Psychosis; depression Nov-2002 Oct-2014
2 Nexium Esomeprazole 1,536,435 0.74% AstraZeneca Gastrointestinal disorders Mar-2000 May-2014
3 Humira Adalimumab 1,461,861 3.86% Abbott Laboratories Rheumatoid arthritis Dec-2002 Dec-2016
4 Crestor Rosuvastatin 1,333,502 4.53% AstraZeneca, Shionogi Cholesterol Nov-2002 Jul-2016
5 Advair Diskus, Seretide Fluticasone/salmeterol 1,247,330 2.65% GlaxoSmithKline Asthma Aug-2000 Mar-2012
6 Enbrel Etanercept 1,189,844 1.46% Amgen Rheumatoid arthritis Nov-1998 Oct-2012
7 Cymbalta Duloxetine 1,064,186 -23.06% Eli Lilly and Company Depression; anxiety disorders Aug-2004 Dec-2013
8 Remicade Infliximab 994,020 -2.71% Centocor Ortho Biotech, Inc., Mitsubishi Tanabe Pharma Crohn's disease; rheumatoid arthritis Aug-1998 n/a
9 Neulasta Filgrastim 854,508 -4.90% Amgen Neutropenia Jan-2002 Mon-20XX
10 Copaxone Glatiramer 851,351 -4.69% Sanofi-Aventis, Teva Pharmaceutical Industries Multiple sclerosis Dec-1996 Nov-2014
11 Lantus Solostar Insulin glargine 839,691 9.39% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 Dec-2011
12 Rituxan, MabThera Rituximab 746,766 -0.16% Biogen Idec, Chugai Pharmaceutical, Genentech/Roche Non-Hodgkin’s lymphoma; rheumatoid arthritis Nov-1997 Mon-20XX
13 Spiriva Tiotropium bromide 726,057 3.39% Boehringer Ingelheim Chronic obstructive pulmonary disease Apr-2002 Jul-2018
14 Januvia Sitagliptin 700,941 3.63% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1996 Nov-2017
15 Atripla Emtricitabine/tenofovir/efavirenz 679,418 0.36% Gilead Sciences, Inc. HIV infection Dec-1996 Mar-2015
16 Lantus Insulin glargine 675,461 5.84% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 Dec-2011
17 Avastin Bevacizumab 650,208 -1.25% Genentech/Roche Cancer Feb-2004 Mon-20XX
18 Lyrica Pregabalin 624,774 2.82% Pfizer Neuropathic pain Jul-2004 Jul-2019
19 OxyContin Oxycodone 585,482 -2.91% Purdue Pharma Pain Dec-1996 Mon-20XX
20 Epogen Epoetin alfa 503,493 −2.08% Amgen Anemia Jun-1989 Mon-20XX
21 Celebrex Celecoxib 580,332 5.23% Pfizer Osteoarthritis; rheumatoid arthritis Dec-1998 May-2014
22 Truvada Tenofovir/emtricitabine 542,846 0.03% Gilead Sciences HIV infection Aug-2004 Mon-20XX
23 Diovan Valsartan 533,924 2.80% Novartis Hypertension Dec-1996 Sep-2012
24 Gleevec, Glivec Imatinib 498,149 7.22% Novartis Leukemia May-2001 Jan-2015
25 Herceptin Trastuzumab 473,632 1.53% Chugai Pharmaceutical, Genentech/Roche Breast cancer Sep-1998 Mon-20XX
26 Lucentis Ranibizumab 460,621 -0.84% Genentech Macular degeneration Dec-1990 Mon-20XX
27 Vyvanse Lisdexamfetamine 447,188 9.39% Shire Attention deficit hyperactivity disorder Dec-1990 Mon-20XX
28 Zetia Ezetimibe 444,731 4.04% Merck & Co., Schering-Plough Cholesterol Oct-2002 Oct-2017
29 Namenda Memantine 434,766 -6.00% Forest Laboratories Alzheimer's disease Oct-2003 Apr-2014
30 Levemir Insulin detemir 424,186 9.34% Novo Nordisk Diabetes mellitus type 1 and 2 Dec-1990 Mon-20XX
31 Symbicort Budesonide/formoterol 407,646 9.63% AstraZeneca Asthma Aug-2000 Mon-20XX
32 Tecfidera Ipratropium bromide/salbutamol 391,404 20.28% Boehringer Ingelheim Chronic obstructive pulmonary disease Oct-1996 Mon-20XX
33 ONE TOUCH ULTRA Telaprevir 370,899 0.00% Johnson & Johnson Hepatitis C Dec-1990 Mon-20XX
34 NovoLog FlexPen Insulin aspart 364,870 7.84% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
35 AndroGel Testosterone gel 351,737 5.47% Abbott Laboratories, Schering-Plough Low testosterone levels Oct-2002 Oct-2016
36 NovoLog Insulin aspart 344,235 3.86% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
37 Enoxaparin Enoxaparin 341,184 6.55% Generic Deep-vein thrombosis Mar-1993 Aug-2012
38 Methylphenidate Methylphenidate 327,346 2.26% Generic Attention deficit hyperactivity disorder Aug-2000 Mon-20XX
39 Suboxone Buprenorphine 321,892 -2.11% Reckitt Benckiser Pharmaceuticals Inc. Pain; opioid addiction Aug-2000 Mon-20XX
40 Xarelto Valsartan/hydrochlorothiazide 321,462 18.72% Ortho-McNeil-Janssen Pharmaceuticals, Inc. Hypertension Dec-1996 Sep-2012
41 ProAir HFA Salbutamol 306,461 10.87% Teva Pharmaceuticals Asthma; chronic obstructive pulmonary disease Oct-1996 Mon-20XX
42 Humalog Insulin lispro 304,866 6.15% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
43 Alimta Pemetrexed 302,728 6.00% Eli Lilly and Company Cancer Feb-2004 Mon-20XX
44 Victoza Liraglutide 301,414 9.59% Novo Nordisk Diabetes mellitus type 2 May-1909 Mon-20XX
45 Viagra Sildenafil 300,463 3.26% Pfizer Erectile dysfunction Mar-1998 Mar-2012
46 Seroquel XR Quetiapine 291,494 2.22% AstraZeneca Psychosis; depression Sep-1997 Mar-2012
47 Synagis Palivizumab 289,704 0.00% MedImmune RSV infection Feb-1998 Aug-2012
48 Avonex Interferon beta 1a 281,554 -1.43% Biogen Idec Multiple sclerosis May-1996 Mon-20XX
49 Renvela Sevelamer 280,917 21.44% Genzyme Corporation, Forest Laboratories Hyperphosphatemia Apr-2002 Apr-2016
50 Rebif Interferon beta 1a 280,548 -6.27% Serono Multiple sclerosis Feb-1998 Mon-20XX
51 Cialis Tadalafil 280,518 4.58% Eli Lilly and Company, Lilly Icos Erectile dysfunction Nov-2002 Mon-20XX
52 Gilenya fingolimod 272,701 4.05% Novartis Corporation Multiple sclerosis Feb-2000 Jan-2007
53 Nasonex Mometasone 272,345 5.67% Schering-Plough Allergic rhinitis Oct-1997 Oct-2018
54 Stelara Ustekinumab 270,598 12.47% Johnson & Johnson Psoriasis; psoriatic arthritis Apr-2000 Mon-20XX
55 Restasis Ciclosporin ophthalmic emulsion 268,463 6.30% Allergan, Inc, Lilly Icos Dry eye syndrome Nov-2002 Mon-20XX
56 Budesonide Budesonide 268,201 26.81% Generic Asthma Aug-2000 Mon-20XX
57 Acetaminophen/hydrocodone Acetaminophen/hydrocodone 264,814 6.67% Generic Pain Aug-2000 Mon-20XX
58 Flovent HFA Fluticasone propionate 263,072 13.97% GlaxoSmithKline Asthma Mar-1996 Mon-20XX
59 Lovaza Omega-3 fatty acid ethyl esters 258,177 2.90% GlaxoSmithKline Cholesterol Jun-2001 Mon-20XX
60 Prezista Darunavir 251,372 3.54% Johnson & Johnson HIV infection Jun-2006 Mon-20XX
61 Isentress Raltegravir 248,924 0.72% Merck & Co., Inc. HIV Infection Dec-1998 Mon-20XX
62 Janumet Sitagliptin/metformin 247,150 4.65% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1998 Mon-20XX
63 Procrit, Eprex Epoetin alfa 241,535 -10.09% Johnson & Johnson Anemia Dec-1990 Mon-20XX
64 Doxycycline Doxycycline 241,381 -5.65% Generic Bacterial infections Dec-1996 Nov-2011
65 Orencia Abatacept 241,149 1.65% Bristol-Myers Squibb Company Rheumatoid arthritis Aug-2000 Mon-20XX
66 Amphetamine/dextroamphetamine Amphetamine mixed salts 240,482 2.78% Generic Attention deficit hyperactivity disorder; narcolepsy Feb-2004 Mon-20XX
67 Vesicare Solifenacin 240,435 5.37% Astellas Pharma US Overactive bladder Feb-2000 Nov-2018
68 Dexilant Dexlansoprazole 238,897 7.57% Takeda Pharmaceuticals North America, Inc Gastrointestinal disorders Dec-2004 Jul-2012
69 Humalog KwikPen Insulin lispro 238,418 11.02% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
70 Neupogen Filgrastim 229,912 -2.70% Amgen Neutropenia Feb-1991 Mon-20XX
71 Lidocaine Lidocaine 225,903 0.00% Generic Pain Mar-1999 Mon-20XX
72 Lunesta Eszopiclone 225,101 5.24% Sunovion Pharmaceuticals Inc. Insomnia Dec-2004 Mon-20XX
73 Fenofibrate Fenofibrate 223,300 -2.22% Generic Cholesterol Feb-1998 Mon-20XX
74 Zytiga Modafinil 222,026 11.86% Centocor Ortho Biotech, Inc Shift work sleep disorder; narcolepsy Dec-1998 Mon-20XX
75 Reyataz Atazanavir 217,793 -1.38% Bristol-Myers Squibb HIV infection Jan-2003 Mon-20XX
76 Sensipar Cinacalcet 216,657 13.71% Amgen Inc. Hyperparathyroidism Apr-2000 Mon-20XX
77 Metoprolol Metoprolol 215,111 2.99% Generic Hypertension Jan-1992 Mon-20XX
78 Invega Sustenna Rabeprazole 214,251 10.03% Janssen Pharmaceuticals, Inc, Johnson & Johnson Gastrointestinal disorders Aug-1999 Nov-2013
79 Synthroid Levothyroxine 213,424 -2.50% Abbott Laboratories Hypothyroidism May-1999 Mon-20XX
80 Avonex Pen Olmesartan 211,917 13.59% Biogen Idec, Forest Laboratories Hypertension Apr-2002 Apr-2016
81 Prevnar 13 Pneumococcal conjugate vaccine 209,367 6.41% Wyeth Pneumococcal disease Feb-2000 Jan-2007
82 Xolair Omalizumab 207,891 1.91% Genentech, Novartis Asthma 2003 Mon-20XX
83 Combivent Respimat Atorvastatin 207,542 4.23% Generic Cholesterol Dec-1996 Nov-2011
84 levothyroxine Fentanyl 204,755 0.00% Generic Pain Aug-1990 Mon-20XX
85 Benicar Olmesartan/hydrochlorothiazide 203,336 3.22% Daiichi Sankyo Hypertension Jun-1909 Mon-2016
86 Stribild Linezolid 202,642 0.00% Pfizer Bacterial infections Apr-2000 Mon-20XX
87 Zostavax Zostavax 202,240 15.17% Eisai, Merck & Co. Herpes zoster Aug-1999 May-2013
88 Pradaxa Dabigatran 200,697 -0.53% Boehringer Ingelheim, Lilly Icos Oral anticoagulant Oct-2010 Mon-20XX
89 Vytorin Ezetimibe/simvastatin 199,625 -3.02% Merck & Co., Schering-Plough Cholesterol Jul-2004 Mon-20XX
90 Tamiflu Oseltamivir 197,718 0.00% Chugai Pharmaceutical, Hetero Drugs, Roche Influenza Oct-1999 Mon-20XX
91 Xgeva Denosumab 197,711 3.24% Amgen Osteoporosis Nov-2010 Mon-20XX
92 Evista Raloxifene 196,929 -4.31% Eli Lilly and Company, Chugai Pharmaceutical Osteoporosis Dec-1997 Jan-2013
93 Xeloda Capecitabine 194,044 6.52% Chugai Pharmaceutical, Genentech Cancer Jun-1909 Mon-20XX
94 Aranesp Darbepoetin alfa 185,225 −9.22% Amgen Inc. Anemia Jun-2001 Mon-20XX
95 Ventolin HFA Salbutamol 183,060 0.00% GlaxoSmithKline Asthma; chronic obstructive pulmonary disease May-1981 Mon-20XX
96 divalproex sodium Omeprazole 181,554 0.00% Generic Gastrointestinal disorders Jun-1909 Mon-20XX
97 Afinitor Dexmethylphenidate 180,719 0.03% Novartis Attention deficit hyperactivity disorder Jun-1909 Mon-20XX
98 Betaseron, Betaferon Interferon beta 1b 179,216 -3.72% Bayer Multiple sclerosis Jul-1993 Mon-20XX
99 Adderall XR Amphetamine mixed salts 177,505 3.31% Shire Attention deficit hyperactivity disorder Oct-2001 Mon-20XX
100 Complera Olmesartan/hydrochlorothiazide 174,933 0.00% Gilead Sciences, Inc. AIDS Jun-20XX Mon-20XX

Source: http://www.drugs.com/stats/top100/sales, Jun 2013

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