List of breast cancer cell lines

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Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer research.[Notes 1]

List of cell lines[edit]

Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53[Notes 2] Tumorigenic in mice Reference
600MPE Invasive ductal carcinoma + [3]
AU565 Adenocarcinoma + [3]
BT-20 Invasive ductal carcinoma Primary No No No Yes Yes [4]
BT-474 Invasive ductal carcinoma Primary Yes Yes Yes Yes Yes [5]
BT-483 Invasive ductal carcinoma + + [3]
BT-549 Invasive ductal carcinoma + [3]
Evsa-T Invasive ductal carcinoma, mucin-producing, signet-ring type Metastasis (ascites) No Yes  ? Yes  ? [6]
Hs578T Carcinosarcoma Primary No No No Yes No [7]
MCF-7 Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes No No (wild-type) Yes (with estrogen supplementation) [8]
MDA-MB-231 Invasive ductal carcinoma Metastasis (pleural effusion) No No No Yes Yes [9]
SkBr3 Invasive ductal carcinoma Metastasis (pleural effusion) No No Yes Yes No [10]
T-47D Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes No Yes Yes (with estrogen supplementation) [11]

Notes[edit]

  1. ^ The original list was mainly based on the work of Lacroix and Leclercq (2004).[1]
  2. ^ For more data on the nature of TP53 mutations in breast cancer cell lines, see Lacroix et al. (2006).[2]

References[edit]

  1. ^ Lacroix M, Leclercq G. (2004). "Relevance of breast cancer cell lines as models for breast tumours: an update". Breast Cancer Res Treat 83 (3): 249–289. doi:10.1023/B:BREA.0000014042.54925.cc. PMID 14758095. 
  2. ^ Lacroix M, Toillon RA, Leclercq G. (2006). "p53 and breast cancer, an update". Endocrine-related cancer 13 (2): 293–325. doi:10.1677/erc.1.01172. PMID 16728565. 
  3. ^ a b c d Neve RM, et al. (2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell 10 (6): 515–527. doi:10.1016/j.ccr.2006.10.008. PMC 2730521. PMID 17157791. 
  4. ^ Lasfargues EY, Ozzello L. (1958). "Cultivation of human breast carcinomas". Journal of the National Cancer Institute 21 (6): 1131–1147. PMID 13611537. 
  5. ^ Lasfargues EY, Coutinho WG, Redfield ES. (1978). "Isolation of two human tumor epithelial cell lines from solid breast carcinomas". Journal of the National Cancer Institute 61 (4): 967–978. PMID 212572. 
  6. ^ Borras M, Lacroix M (1997). "Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers". Cancer Letters 120 (1): 23–30. doi:10.1016/S0304-3835(97)00285-1. PMID 9570382. 
  7. ^ Hackett AJ, Smith HS, Springer EL, Owens RB, Nelson-Rees WA, Riggs JL, Gardner MB. (1977). "Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines". Journal of the National Cancer Institute 58 (6): 1795–1806. PMID 864756. 
  8. ^ Soule HD, Vazguez J, Long A, Albert S, Brennan M. (1973). "A human cell line from a pleural effusion derived from a breast carcinoma". Journal of the National Cancer Institute 51 (5): 1409–1416. PMID 4357757. 
  9. ^ Cailleau R, Young R, Olivé M, Reeves WJ Jr. (1974). "Breast tumor cell lines from pleural effusions". Journal of the National Cancer Institute 53 (3): 661–674. PMID 4412247. 
  10. ^ Engel LW, Young NA. (1978). "Human breast carcinoma cells in continuous culture: a review". Cancer Research 38 (11 Pt 2): 4327–4339. PMID 212193. 
  11. ^ Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaitcik S, Brenner HJ. (1979). "Establishment and characterization of a cell line of human breast carcinoma origin". European Journal of Cancer 15 (5): 659–670. doi:10.1016/0014-2964(79)90139-7. PMID 228940.