During the 1960s trend for action-adventure spy thrillers, it was a common practice for fictional spy organizations or their nemeses to employ names that were contrived acronyms. Sometimes these acronyms' expanded meanings made sense, but most of the time they were words incongruously crammed together for the mere purpose of obtaining a catchy acronym, traditionally a heroic sounding one for the good guys and an appropriately menacing one for the bad guys. This has become one of the most commonly parodied clichés of the spy thriller genre. They were presumably inspired by SMERSH, which appeared in the James Bond stories and sounded fictional, but really was a branch of Soviet intelligence. These acronyms are often spelled with periods/points/stops to make it clear that they stand for longer terms and are not simply the usual English words that they resemble, even though the punctuation would otherwise seem to indicate that the abbreviations should be pronounced as the names of the individual letters.
F.L.A.G. (Foundation for Law And Government), from the original Knight Rider
F.O.W.L. (Fiendish Organization for World Larceny), in cartoon series, Darkwing Duck. This organization originated in the DuckTales episode "Double-o-Duck", but was called the Foreign Organization there.
G.R.A.M.P.A. (Global Reaction Agency for Mysterious Paranormal Activity), an international intelligence agency in Marvel Comics.
G.R.O.S.S. (Get Rid Of Slimy girlS), an organization founded by Calvin from the Calvin and Hobbes comic series which seeks to exclude girls because of their inherent slimy nature.
H.A.M.M.E.R., a fictional agency representing former USSR territories and Cuba in the video game Evil Genius
H.A.R.M., from the No One Lives Forever (NOLF) series of computer games, which were released in the 1990s, but were based in 1960s pop culture. What H.A.R.M. actually stands for is never revealed, and speculation about its true meaning is the subject of several jokes in both games. (However, in the 1966 spy film Agent for H.A.R.M., it stands for Human Aetiological Relations Machine.)
S.H.I.E.L.D. (originally Supreme Headquarters, International Espionage, Law Enforcement Division; later Strategic Hazard Intervention, Espionage and Logistics Directorate and Strategic Homeland Intervention, Enforcement and Logistics Division), from the Nick Fury, Agent of S.H.I.E.L.D.Marvel Comics.
T.I.A. (Técnicos Investigación Aeroterráquea) translating into "Aeroterraquatic (air, land, sea) Investigation Technicians", from the Spanish comic strip Mortadelo y Filemón.
U.G.L.I. (Undercover Global League of Informants) in the Hardy Boys book, Secret Agent of Flight 101.
U.N.C.L.E. (United Network Command for Law and Enforcement) and T.H.R.U.S.H., from The Man from U.N.C.L.E.. (The meaning of T.H.R.U.S.H. was never revealed on the series; but, in the novelizations it was stated to be "Technological Hierarchy for the Removal of Undesirables and the Subjugation of Humanity".)
U.N.I.T. (United Nations Intelligence Taskforce) A military organization formed to investigate and combat paranormal and extraterrestrial threats to the Earth in the series Doctor Who. UNIT was rebranded as the UNified Intelligence Taskforce in 2008, after the United Nations expressed its discomfort with being associated with a fictional paramilitary organization.
V.E.N.O.M. (The Vicious, Evil Network Of Mayhem), the evil mask-wearing cohort from the 1980s Saturday-morning cartoon M.A.S.K.