In addition to the archetypical mad scientist, western culture depicts scientists and engineers who go above and beyond the regular demands of their professions to use their skills and knowledge for the betterment of others, often at great personal risk. In this list of fictional scientists and engineers, an annotated alphabetical overview is given of some of the best-known beings in this category.
Dr. Sam Beckett (Quantum Leap) — Nobel-prizewinning quantum physicist (with multiple doctorates) caught in his own time-travel experiment; "leaping" into many lives along the span of his own lifetime, he must change the histories of those around him for the better before he can return home
Dr. Walter Bishop (Fringe (TV series)) — genius and mad scientist (literally). Responsible for opening a doorway into another universe in order to save an alternate version of his son Peter from dying. His actions have resulted in the gradual breakdown of both universes and inadvertently started a war between them. He, along with Peter, FBI Special Agent Olivia Dunham and FBI Junior Agent Astrid Farnsworth attempt to solve a number of weird (or fringe) events and crimes; some of which are a direct result of Walter's action of opening a doorway into another universe.
Seth Brundle (The Fly) — eccentric but brilliant physicist who invented the "telepods," machines capable of teleportation
Professor Cuthbert Calculus (The Adventures of Tintin) — brilliant, if distracted, scientist. He is responsible for developing the first one-man submarine, the first ultrasonic destruction device, and the first white rose. Calculus is also the leader of the first manned lunar mission.
Professor Monty Corndog (The Aquabats / The Aquabats! Super Show!) — eccentric scientist and inventor whose chemical creations turned a group of ordinary men into superhero rock musicians who fight crime with the aide of The Professor's gadgets and contraptions
Dr. Stanley Goodspeed (The Rock) — FBI chemical weapons specialist
Leonid Gorbovsky (Noon Universe) — genius scientist, progressor and spaceship captain who is known for his ability to land on even the most dangerous planets, to survive planet-wide catastrophes and easily making contact with any non-human civilization
Franz Hopper, (Code Lyoko) — genius in quantum physics and computer programming responsible for the creation of the virtual reality Lyoko, Malevolent AI XANA and the advanced hardware that support both
Dr. Elias Huer, (Buck Rogers) — chief scientist and inventor in the comic strip, movie serial and television series
Dr. Daniel Jackson (Stargate and Stargate SG-1) — archaeologist and linguist who figures out how to open the Stargate; his understanding of cultures and languages typically comes in handy when dealing with the bewildering array of cultures in the Stargate universe.
Angus "Mac" MacGyver (MacGyver) — secret agent who fights the forces of evil using his scientific and engineering knowledge to his advantage
Ian Malcolm (Jurassic Park) — mathematician and chaotician surviving numerous encounters with dinosaurs and other hazards. His mathematical prowess does not help so much as allow him to predict his own fate, and that of the park's inhabitants
Leonard McCoy (Star Trek: The Original Series) — chief medical officer of the Enterprise
Dr. Cal Meacham (This Island Earth) — Earth scientist (a radio engineer in the novel) kidnapped to solve the problem of defending the planet Metaluna
Dr. Harold Medford (Them!) — led team that wiped out the giant ants
Dr. Alphonse Mephesto, aka Dr. Mephesto (South Park) — mad scientist who specializes in genetic engineering. Dr. Mephesto creates strange creatures with his talents, however his creations are things like animals with multiple buttocks. Mephesto believes it is for the good of the Earth, and that one-assed animals are useless and must be destroyed. He even goes as far as presenting a "seven-assed Galapagos Turtle" in an attempt to win a Nobel Prize, but loses to Randy Marsh's "Unified Theory of Fart Thing". He also performs experiments ranging from simple DNA tests to creating a genetic clone of Stan Marsh for his son's science project
Dr. Moreau (The Island of Doctor Moreau) — vivisectionist who has fled scandal to live on a remote island in the Pacific to pursue his research of perfecting his Beast Folk
Quinn Pensky and Paige Howard (Zoey 101) — 13-year-old female mad scientist, best known for her "Quinventions"
Q (James Bond) — makes all the gadgets 007 uses. Q is most often portrayed using the conventional literary trappings of a scientist (white lab coat etc.), even though his activities are closer to engineering
Dr. Hoenneger (The Wolfman (2010 film)) - a German doctor who worked at an insane asylum and used medical torture to "treat" Lawrence Talbot's belief that he transformed into a werewolf every full moon. Little did Dr. Hoenneger know that Talbot wasn't mentally ill and that he truly was a werewolf.
Dr. Alphonse Mephesto (South Park) – a mad scientist, who specializes in genetic engineering. Dr. Mephesto creates strange creatures with his talents. He also performs experiments ranging from simple DNA tests to creating a genetic clone of Stan Marsh for his son's science project
Bulma (Dragon Ball) – Creator of the Dragon Radar and a time machine allowing Trunks to avert the conquest of the world by evil androids
Doctor Ivo Robotnik (Sonic) – A mad scientist and engineer, who invents various kinds of aircraft, robots and vehicles in various sizes (most Sonic games). He imprisoned animals in the inside of working robotic shells (Sonic 1 - Sonic adventure 2), and experimented with kinds of mutations (Sonic Unleashed)
Albert Wesker (Resident Evil) – Microbiologist working for the pharmaceutical enterprise Umbrella and co-creator of the T-virus. He was killed in the first Resident Evil game by Tyrant T-002, a powerful biological weapon, and was resurrected with super-human powers after self-injecting the T-virus.
Genis Sage (Tales of Symphonia) – Lloyd Irving's super smart friend who has the ability to use extreme amounts of magic and is always there for Lloyd while being the voice of reason and choice
Cave Johnson (Portal 2) – The eccentric former owner of Aperture Science, and creator of the portal gun
Mordin Solus (first appeared in Mass Effect 2) – a member of fictional alien species known as salarians (who mostly have fast metabolism, talk fast, walk fast and think fast), he is a brilliant biologist and a tech specialist.
Daro'Xen vas Moreh (first appeared in Mass Effect 2) – a quarian admiral and scientist who believes that the geth, a synthetic race created by the quarians, who subsequently rebelled and drove their masters from their homeworld, should be controlled by the quarians once again. Admiral Xen also performed surgery on her childhood toys, much to the quarian squadmate Tali'Zorah's disgust
Lucca (Chrono Trigger) – Fighter and inventor, who, among other things, builds a time-machine and repairs a robot from over a millennium in the future
Cid (Final Fantasy) – Although there are many different individuals with the name of Cid in many different Final Fantasy games, most of them are some sort of scientist, with few exceptions. His existence is a tradition on par with the Chocobo in the series.
Dr. "Mundo" Edmundo (League of Legends) – A sociopath medical doctor who only specializes in one field: the study of the pain response and how to inflict pain. His experiments have caused him to take on a monstrous form reminiscent of Frankenstein's Monster and a deceptively dimwitted speech pattern. Out of all the scientists in the game, Dr. Mundo stands out as the only one who is a danger to both himself and others, evident in his self experiments.
The Engineer (Team Fortress 2) – one of nine playable classes who is capable of building sentry guns for area denial and other constructions which may support other characters
The Medic (Team Fortress 2) – one of nine playable classes who is able to heal other characters and make them immortal (Übercharge them) for a limited time with his fictional device called Medigun
Dr. Bruce Banner, aka The Incredible Hulk (Hulk) – Scientist who developed the "Gamma Bomb" for the US Government. An accident at the site of a test led to his becoming the Hulk. For a long period after, while in the form of Bruce Banner, he would look for scientific ways to rid himself of the transformation.
Dr. Jon Osterman aka Dr. Manhattan (Watchmen) nuclear physicist transformed by accident into a godlike super-being. While publicized as a superhero, he functions as the ultimate weapon for the United States military
Ray Palmer aka Atom (The Atom) – Professor of Physics at Ivy University. Able to shrink his body to varying degrees, even to sub-atomic level, and able to alter his mass to near infinite levels
Peter Parker aka Spider-Man (Spider-Man) – Superhero with great knowledge of advanced sciences, who now teaches at the High School he went to
Victor Von Doom, aka Doctor Doom (Doctor Doom) – Evil Scientist, Engineer, Genius, Conqueror. Doctor Doom, like Mister Fantastic, is regarded as one of the most intelligent people on Earth, even though he is a villain.
Ted Sallis, duplicator of the serum that created Captain America, transformed into The Man-Thing. Although he had serious problems with his personal ethics when it came to women and girls, he abandoned Operation Sulfer on moral grounds, and elected to remain as Man-Thing rather than allow innocents to be killed by the demon Thog.
Tony Stark, aka Iron Man (Iron Man) – An industrialist and electrical engineer of incredible ingenuity and inventive genius, whose technology to fight crime keeps him alive as well. He suffers from alcoholism.
Doctor Vegapunk (One Piece) – The leading scientist in the employment of the Marines. His work includes discovering the secrets and uses of Seastone as well as the secrets of how Devil Fruit powers work.
Caesar Clown (One Piece) – Former marine scientist and former partner of Doctor Vegapunk. He created mass destruction weapons and human experimentation but was fired and arrested due to his unethical research methods.
Doctor Hogback (One Piece) – The Doctor of Gecko Moria's crew who modified dead bodies to create a zombie army with the help of his Captain
The Doctor (Hellsing)-The lead scientist of Millennium who created the nazi vampires and the catboy Schrodinger.
Jotaro Kujo (JoJo's Bizarre Adventure) - While unrelated to his role in the plot of the various arcs he appears in, Jotaro earns a doctorate in marine biology sometime before 1999 in the series' original timeline. Dolphin and anchor motifs were added to his clothing designs to reflect his new occupation.