List of hematologic conditions

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This is an incomplete list, which may never be able to satisfy certain standards for completion.

There are many conditions of or affecting the human hematologic system — the biological system that includes plasma, platelets, leukocytes, and erythrocytes, the major components of blood and the bone marrow.[1]

Anemias[edit]

The pale hand of a woman with severe anemia (left) in comparison to the normal hand of her husband (right)
Main article: Anemia

An anemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood.[2][3] However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency.

Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Based on 2005-2006 estimates, the Centers for Disease Control and Prevention has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis.[4]

Nutritional anemias[edit]

A nutritional anemia is a type of anemia that can be directly attributed to either a nutritional disorder or a nutritional deficiency.

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Iron deficiency anemia D50 6947
Iron deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed.[5]
Plummer-Vinson syndrome D50.1 10134
Plummer-Vinson syndrome (PVS), also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia (due to esophageal webs), glossitis, and iron deficiency anemia.[6] It most usually occurs in postmenopausal women.
Vitamin B12 deficiency anemia E53.8 13905
Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells.[7]
Vitamin B12 deficiency anemia due to intrinsic factor deficiency D51.0
Vitamin B12 deficiency is caused by a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency.
Pernicious anemia D51.0 9870
Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Pernicious anemia is the result of inadequate production of the protein intrinsic factor needed by the body to absorb vitamin B 12, causing a reduction of new red blood cells.[8]
Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria
Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria (also known as Imerslund-Gräsbeck syndrome) is a rare autosomal recessive disorder which requires the indefinite administration of Vitamin B12 injections.[9]
Megaloblastic hereditary anemia D51.1, D52.0, D53.1 29507
Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10]
Transcobalamin II deficiency D51.2
Transcobalamin II deficiency (TCII) (also known as hereditary transcobalamin II deficiency) is a rare autosomal recessive disorder that results in neurological dysfunction.[11] Transcobalamin II are a type of carrier proteins which bind with plasma vitamin B12 (cobalamin) in the production of red blood cells.[12]
Folate-deficiency anemia D52 E53.8 4894
Folate-deficiency anemia (also known as dietary folate-deficiency anemia) is a condition that develops when the body does not have the adequate supply of folic acid available that is needed for the production of new healthy blood cells.[13]
Nutritional megaloblastic anemia D51.1, D52.0, D53.1 29507 D000749
Nutritional Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10]
Drug-induced folate deficiency anemia D52.1
Protein deficiency anemia
Protein deficiency anemia is an anemia that results from an inadequate intake of dietary protein.[14]
Scurvy E54 13930
Scurvy is a disease resulting from a deficiency of vitamin C,[15] which is required for the synthesis of collagen in humans.

Non-nutritional (hemolytic, aplastic and other) anemias[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Acanthocytosis
Acanthocytosis can refer generally to the presence of this type of crenated red blood cell, such as may be found in severe cirrhosis or pancreatitis,[16]:150 but can refer specifically to abetalipoproteinemia, a clinical condition with acanthocytic red blood cells, neurologic problems and steatorrhea.[17]:2464 This particular cause of acanthocytosis (also known as abetalipoproteinemia, apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive condition due to the inability to fully digest dietary fats in the intestines as a result of various mutations of the microsomal triglyceride transfer protein (MTTP) gene.[18]
Acute posthemorrhagic anemia D62.0
Acute posthemorrhagic anemia (also known as acute blood loss anemia) is a condition in which a person quickly loses a large volume of circulating hemoglobin. Acute blood loss is usually associated with an incident of trauma or a severe injury resulting in a large loss of blood. It can also occur during or after a surgical procedure.[19]
Alpha-thalassemia D56.0 448, 33334, 33678
Alpha-thalassemia (α-thalassemia) is a form of thalassemia involving the genes HBA1 [20] and HBA2.[21] It is condition that causes a reduction of hemoglobin production. There are two types of Alpha-thalassemia, named hemoglobin Bart hydrops fetalis syndrome (also known as Hb Bart syndrome) and HbH disease.[22]
Anemia D50-D64 663
Anemia is a type of medical condition that results in a decrease in the number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood.[2]
Anemia of chronic disease
Anemia of chronic disease (ACD) (also known as anemia of inflammatory response) is a condition where the body converts iron into unused ferrin, causing a drop in hemoglobin production, and as a result; decreased red blood cell production and count. This is caused by a natural defense mechanism initiated by an inflammatory response in response to the underlying chronic disease.[23]
Anemia in kidney disease and dialysis
Anemia in kidney disease and dialysis results from the diseased kidney's inability to produce enough of the hormone erythropoietin. Erythropoietin is used to stimulate an adequate production of red blood cells from the bone marrow.[24]
Anemia of prematurity P61.2
Anemia of prematurity is a form of anemia affecting preterm infants[25] with decreased hematocrit.[26]
Aplastic anemia D60-D61 866
Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells.[27]
Autoimmune hemolytic anemia D59.0-D59.1
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis).[28][29] Types of AIHA include warm autoimmune hemolytic anemia, cold agglutinin disease, and paroxysmal cold hemoglobinuria.
Beta-thalassemia D56.1 3087
Beta-thalassemia (β-thalassemia) is an autosomal dominant blood condition that results in the reduction of hemoglobin production. The cause for the disorder is related to a genetic mutation of the HBB gene. This gene is responsible for providing the instructions to produce beta-globin; one of the major components of hemoglobin. The two classification types of beta thalassemia are thalassemia major (also known as Cooley's anemia) and thalassemia intermedia.[30]
Diamond-Blackfan anemia D61.0 29062
Diamond–Blackfan anemia (DBA), (also known as Blackfan–Diamond anemia and Inherited erythroblastopenia) [31] is a congenital erythroid aplasia that usually presents in infancy.[32]
Congenital dyserythropoietic anemia D64.4
Congenital dyserythropoietic anemia (CDA) is a generically inherited autosomal recessive (types I and II) or autosomal dominant (type III) blood disorder that affects the normal maturation process of red blood cell production. Mutations to the CDAN1 gene (type I), SEC23B gene (type II), and a currently unknown gene for type III causes a disruption in the normal formation of erythropoiesis, thereby causing a reduction of circulating healthy mature red blood cells.[33]
Drug-induced autoimmune hemolytic anemia D59.0
Drug-induced autoimmune hemolytic anemia is a type of hemolytic anemia in which a mediated immune response triggers IgG and IgM antibody production in regards to the presence of high doses of penicillin via the hapten mechanism causing the reduction of red blood cells in the spleen.[34]
Drug-induced nonautoimmune hemolytic anemia
Glucose-6-phosphate dehydrogenase deficiency D55.0 19674 D005955
Hemoglobinopathy D58.2 5037
Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule.[35] Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits.[36] Hemoglobinopathies imply structural abnormalities in the globin proteins themselves.[37] Hemoglobinopathy variants include sickle-cell disease.[38]
Hemolytic anemia D55-D59 5534
Hemolytic anemia (also known as haemolytic anaemia) is an anemia due to hemolysis, the abnormal breakdown of red blood cells. A number of different mediating factors can cause this condition; either from within the blood cell itself ((intrinsic factors) or outside of the cell (extrinsic factors).[39]
Congenital hemolytic anemia
Fanconi anemia D61.0 4745 D005199
Fanconi anemia is a rare genetic autosomal recessive aplastic anemia that involves chromosomes 9q and 20q.[40]
Hereditary spherocytosis D58.0 5827
Hereditary spherocytosis is a genetically-transmitted (autosomal dominant) form of spherocytosis, an auto-hemolytic anemia characterized by the production of red blood cells that are sphere-shaped rather than bi-concave disk shaped (donut-shaped), and therefore more prone to hemolysis.[41]
Hereditary elliptocytosis D58.1 4172
Hereditary elliptocytosis (HE) (also known as ovalocytosis), is an inherited blood disorder in which an abnormally large number of circulating red blood cells are elliptical or cigar shaped rather than the typical biconcave disc shape. It is caused in part by mutations in the formation of specific spectrin tetramers or proteins responsible for giving the red blood cell its shape and elasticity causing continued deformation as the cell matures.[42] Subtypes of this condition include southeast Asian ovalocytosis and spherocytic elliptocytosis.
Hereditary pyropoikilocytosis
Hereditary pyropoikilocytosis (HPP) is an autosomal recessive form of hemolytic anemia which typically presents at infancy or early childhood, characterized by abnormal red blood cell morphology including "budding red cells, fragmented red cells, spherocytes, elliptocytes, triangular cells, and other bizarre-shaped red cells." [43]
Acquired hemolytic anemia
Cold hemagglutinin disease D59.1 2949
Cold hemagglutinin disease (also known as cold agglutinin disease and autoimmune anemia due to cold-reactive antibodies)is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells.[44] It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31 °C.
Paroxysmal cold hemoglobinuria D59.6 9679
Paroxysmal cold hemoglobinuria (PCH) (also known as Donath-Landsteiner syndrome) is a rare condition characterized by the sudden presence of hemoglobin in the urine (called hemoglobinuria), typically after exposure to cold temperatures.[45]
Hemolytic-uremic syndrome D59.3 13052
Hemolytic-uremic syndrome (HUS) (also known as haemolytic-uraemic syndrome) is a disease characterized by hemolytic anemia, acute renal failure (uremia) and a low platelet count (thrombocytopenia). It predominantly but not exclusively affects children. Most cases are preceded by an episode of diarrhea caused by E. coli O157:H7, which is acquired as a foodborne illness.[46]
Hereditary persistence of fetal hemoglobin
Hereditary stomatocytosis | |D58.8 29710
Hereditary stomatocytosis is a classification of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell 'leaks' sodium and potassium ions, causing cell lyses and eventual haemolytic anaemia.
Hexokinase deficiency D55.2
Hexokinase deficiency (also known as human erythrocyte hexokinase deficiency) is an anemia-causing condition associated with inadequate hexokinase.[47]
Hyperanaemia
Hypochromic anemia
Hypochromic anemia is any type of anemia in which the red blood cells (erythrocytes) are paler than normal.[48] This is caused by a proportionally reduced amount of hemoglobin present in relation to the size of the red blood cell.
Ineffective erythropoiesis
Ineffective erythropoiesis is an anemia caused by the premature apoptosis of the body's mature red blood cells [49] and subsequent reduction in an adequate production and full maturation of new healthy red blood cells.[50]
Macrocytic anemia
Megaloblastic anemia D51.1, D52.0, D53.1 29507
Megaloblastic anemia (or megaloblastic anaemia) is an anemia of macrocytic classification that results from inhibition of DNA synthesis in red blood cell production.[10]
Microangiopathic hemolytic anemia
Minkowski-Chauffard syndrome
Myelophthisic anemia D61.9
Myelophthisic anemia (also known as myelophthisis) is a severe kind of anemia found in some people with diseases that affect the bone marrow. Myelophthisis is the displacement of hemopoietic bone-marrow tissue into the peripheral blood,[51] either by fibrosis, tumors or granulomas.
Neuroacanthocytosis 29707 D054546
Neuroacanthocytosis (also known as Levine-Critchley syndrome) is a group of rare, genetic conditions that are characterized by movement disorders and acanthocytosis.[52]
Chorea acanthocytosis 29707 D054546
Chorea-acanthocytosis (ChAc)(also known as Levine-Critchley syndrome, acanthocytosis with neurologic disorder, neuroacanthocytosis, and choreoacanthocytosis)[53] is a rare hereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells. It belongs to a group of four diseases characterized as neuroacanthocytosis.[54]
Non sideropenic hypochromic anaemia
Normocytic anemia
A normocytic anemia is an anemia with a mean corpuscular volume (MCV) of 80-100.
Paroxysmal nocturnal hemoglobinuria D59.5 9688
Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired, life-threatening blood disease, with anemia due to red blood cell destruction, red urine, and thrombosis.
Pyruvate kinase deficiency D55.2 11090
Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency,[55] is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells and causes them to deform into echinocytes on peripheral blood smears.
Rh deficiency syndrome
Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition.[56]
Sickle-cell disease
Sideroblastic anemia D64.0-D64.3 12110
Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).[57] It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome.[58]
Southeast Asian ovalocytosis D58.1 9416
Southeast Asian ovalocytosis (also known as stomatocytic ovalocytosis, stomatocytic elliptocytosis, and Melanesian ovalocytosis) is a form of hereditary elliptocytosis common in some communities in Malaysia and Papua New Guinea, as it confers some resistance to cerebral falciparum malaria.[59]
Spur cell hemolytic anemia
Spur cell hemolytic anemia is a form of hemolytic anemia that results when free cholesterol binds to the red blood cell's membrane increasing its surface area, causing later deformities such as rough or thorny projections on the erythrocyte named acanthocytes. This condition is caused by the deceased liver's decreased ability to esterificate cholesterol.[60]
Thalassemia D56 D013789
Triosephosphate isomerase deficiency D55.2 30116
Triosephosphate isomerase (TPI) deficiency is a genetically inherited autosomal recessive condition "characterized bychronic hemolytic anemia, cardiomyopathy, susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early childhood." [61]
Warm autoimmune hemolytic anemia D59.1 29723
Warm autoimmune hemolytic anemia is an autoimmune hemolytic anemia (AIHA) characterized by formation of antibodies that attack the body's own red blood cells in a destructive immune system response.[62]

Blood cancers[edit]

Seven-year-old Nigerian boy with Burkitt's lymphoma presenting with a severely ulcerated and swollen jaw

A blood cancer or hematological malignancy is a type of malignant cancer that originates, affects, or involves the blood, bone marrow, or lymph nodes.[63] These cancers include leukemias, lymphomas, and myelomas. These particular types of cancers can arise as defected mature cell types that have differentiated from hematopoietic precursor cells (often in the bone marrow) and begin to quickly proliferate through the bloodstream where it can then often infiltrate other organs and tissues. Others can involve the formation of tumors from lymphoblasts from within the lymphoid tissue.[64] Incidence of affected people with a form of blood cancer has been steady increasing over recent years; however, due in part to early detection methods and subsequent advancements in the treatment of the diseases, mortality rates have continued to decrease.[65]

Lymphoma[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Hodgkin lymphoma C81 5973
Non-Hodgkin lymphoma C82-C85 9065
The non-Hodgkin lymphomas (NHLs) are a diverse group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas.[66]
Anaplastic large cell lymphoma
Angioimmunoblastic T-cell lymphoma C84.4
Angioimmunoblastic T-cell lymphoma (AILT) (also known as Angioimmunoblastic lymphadenopathy with dysproteinemia) [67]:747) is a mature T-cell lymphoma with systemic characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement.[68] It is also known as immunoblastic lymphadenopathy (Lukes-Collins Classification) and AILD-type (lymphogranulomatosis X) T-cell lymphoma (Kiel Classification).[68]
Hepatosplenic T-cell lymphoma
Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow.[69] It is a rare and generally incurable form of lymphoma.[70]
B-cell lymphoma
reticuloendotheliosis
reticulosis
Microglioma
Diffuse large B-cell lymphoma
Follicular lymphoma C82
Follicular lymphoma (also known as indolent follicular lymphoma) is a type of non-Hodgkin's lymphoma that involves both large and small B-cell lymphocytes that spreads from the lymphatic system and into the blood, bone marrow, and internal organs. Approximately 20 to 30 percent of non-Hodgkin's lymphomas are diagnosed as follicular lymphoma, with a majority of cases involving those 60 years of age or older.[71]
Mucosa-associated lymphatic tissue lymphoma 31339
Mucosa-associated lymphatic tissue lymphoma (as known as MALT lymphoma and extra-nodal marginal zone lymphoma) is a condition in which lymphatic tissue abnormally presents outside the lymphatic system (extra-nodular) and instead within the mucosa of the gastrointestinal tract, typically as a lesion in the stomach.[72]
B-cell chronic lymphocytic leukemia C91.1 2641
B-cell chronic lymphocytic leukemia (also known as small cell lymphocytic lymphoma) is a blood cancer that involves the B-cell lymphocytes; responsible for the creation of antibodies. Of the two general types of chronic lymphocytic leukemias (the other involving T-cells), B-cell chronic lymphocytic leukemia accounts for approximately 95 percent of the diagnoses.[73]
Mantle cell lymphoma C85.7
Mantle cell lymphoma (MCL) is a type of B-cell lymphoma and one of the rarest forms of non-Hodgkin's lymphomas comprising approximately 6% of diagnosed cases.[74]
Burkitt lymphoma C83.7 1784
Burkitt lymphoma (also known as Burkitt's tumor or malignant lymphoma, Burkitt's type) is a type of B-cell lymphoma that is categorized into one of variant types. These variants are endemic (occurring in equatorial Africa), sporadic ("non-African"), and immunodeficiency-associated (usually associated with HIV).
Mediastinal large B cell lymphoma
Waldenström's macroglobulinemia C88.0 14030
Waldenström's macroglobulinemia (also known as lymphoplasmacytic lymphoma) is a lymphoproliferative disease that involves an abnormal increase of lymphocytes within the bone marrow, creasing disruption of normal red blood cell production.[75]
Nodal marginal zone B cell lymphoma
Splenic marginal zone lymphoma
Splenic marginal zone lymphoma (SMZL) (also known as well-differentiated lymphocytic lymphoma, small lymphocytic lymphoma, and splenic lymphoma with circulating villous lymphocytes) is a lymphoma made up of small B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood.[76]
Intravascular large B-cell lymphoma
Primary effusion lymphoma 33904
Primary effusion lymphoma is a condition caused by Kaposi's sarcoma-associated herpesvirus (KSHV).[77]
Lymphomatoid granulomatosis
Nodular lymphocyte predominant Hodgkin's lymphoma

Leukemia[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
plasma cell leukemia C90.1 D007952
Plasma cell leukemia (PCL), a lymphoproliferative disorder,[78] is a rare cancer involving a subtype of white blood cells called plasma cells.[79]
Acute erythraemia and erythroleukaemia
Acute erythremic myelosis
Acute erythroid leukemia C94.0
Acute erythroid leukemia (also known as Guglielmo's disease, and acute Di Guglielmo syndrome) is a rare form of acute myeloid leukemia.
Heilmeyer-Schöner disease
Acute megakaryoblastic leukemia D007947
Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia where megakaryoblasts account for approximately 30% of the nucleated cells within the bone marrow.[80]
Acute megakaryoblastic leukemia
Mast cell leukemia
Panmyelosis C94.4
Acute panmyelosis with myelofibrosis C94.4
Acute panmyelosis with myelofibrosis (APMF) is a poorly defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow.
Lymphosarcoma cell leukemia
Acute leukaemia of unspecified cell type
Blastic phase chronic myelogenous leukemia
Blastic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which more than 30% of the cells in the blood or bone marrow are blast cells.
Stem cell leukemia
Chronic leukaemia of unspecified cell type
Subacute leukaemia of unspecified cell type
Accelerated phase chronic myelogenous leukemia
Acute myeloid leukemia C92.0 203
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.[81]
Polycythemia vera
Acute promyelocytic leukemia
Acute basophilic leukemia
Acute eosinophilic leukemia
Acute lymphoblastic leukemia
Acute monocytic leukemia
Acute myeloblastic leukemia with maturation
Acute myeloid dendritic cell leukemia
Adult T-cell leukemia/lymphoma
Aggressive NK-cell leukemia
B-cell prolymphocytic leukemia
B-cell chronic lymphocytic leukemia
B-cell leukemia
Chronic myelogenous leukemia
Chronic myelomonocytic leukemia p
Chronic neutrophilic leukemia
Hairy cell leukemia
Chronic idiopathic myelofibrosis
Myleofibrosis is one of the myeloproliferative neoplasms.

Myeloma[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Multiple myeloma
Kahler's disease
Myelomatosis
Solitary myeloma
Plasma cell leukemia
Plasmacytoma, extramedullary
Malignant plasma cell tumour NOS
Plasmacytoma NOS

Malignant immunoproliferative diseases[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Monoclonal gammopathy
Angiocentric immunoproliferative lesion
Lymphoid granulomatosis
Angioimmunoblastic lymphadenopathy
T-gamma lymphoproliferative disease
Waldenström's macroglobulinaemia
Alpha heavy chain disease
Gamma heavy chain disease
Franklin's disease
Immunoproliferative small intestinal disease
Mediterranean disease
Malignant immunoproliferative disease, unspecified
Immunoproliferative disease NOS

Coagulation, purpura, and other hemorrhagic conditions[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Disseminated intravascular coagulation (DIC, defibrination syndrome)
Protein C deficiency
Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease.[82]
Protein S deficiency
Thrombocytosis
Idiopathic thrombocytopenic purpura D69.3 6673 D016553
Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic).
Recurrent thrombosis
Hemophilia
Hemophilia A
Hemophilia B
Hemophilia C
Von Willebrand disease
Antiphospholipid syndrome
Thrombocytopenia
Glanzmann's thrombasthenia
Wiskott-Aldrich syndrome

Infection-related[edit]

Hematological disorders may be caused by a number of infection-related conditions involving the introduction of microorganisms into the host, such as bacteria and protozoa.[40]

Bacterium-related[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Clostridium infection
Cholera infection
E. coli 0157:H7 infection
Typhoid fever

Protozoan-related[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Leishmania infection *
Malaria infection (Plasmodium infection)
Toxoplasmosis

Immune system regulation-related[edit]

Immunodeficiency with predominantly antibody defects[edit]

Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings
Hereditary hypogammaglobulinemia
Nonfamilial hypogammaglobulinemia
Selective deficiency of immunoglobulin A [IgA]
Selective deficiency of immunoglobulin G [IgG] subclasses
Selective deficiency of immunoglobulin M [IgM]
Immunodeficiency with increased immunoglobulin M [IgM]
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
Transient hypogammaglobulinemia of infancy

References[edit]

  1. ^ Saladin, Kenneth S.; Miller, Leslie (2004). "18". Anatomy & Physiology: The Unity of form and Function (3rd ed.). McGraw-Hill. p. 679. ISBN 0-07-242903-8. 
  2. ^ a b MedicineNet.com --> Definition of Anemia Last Editorial Review: 12/9/2000 Retrieved March 27, 2011
  3. ^ Merriam-Webster Dictionary --> anemia Retrieved on March 27, 2011
  4. ^ "Anemia or Iron Deficiency". Centers for Disease Control and Prevention. Last reviewed April 15, 2010. Retrieved 28 March 2011. 
  5. ^ Brady PG (2007). "Iron deficiency anemia: a call for". South. Med. J. 100 (10): 966–7. doi:10.1097/SMJ.0b013e3181520699 (inactive 2010-01-09). PMID 17943034. 
  6. ^ Novacek G (2006). "Plummer-Vinson syndrome". Orphanet J Rare Dis 1: 36. doi:10.1186/1750-1172-1-36. PMC 1586011. PMID 16978405. 
  7. ^ Mayo Clinic staff (March 4, 2011). "Vitamin deficiency anemia". Mayo Foundation for Medical Education and Research. Mayo Clinic. Retrieved 5 March 2011. 
  8. ^ "Pernicious anemia". National Center for Biotechnology Information (NCBI). U.S. National Library of Medicine. November 23, 2008. Retrieved 1 March 2011. 
  9. ^ Gräsbeck, R. (May 19, 2006). "Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)". Orphanet J Rare Dis (National Center for Biotechnology Information, U.S. National Library of Medicine) 1: 17. doi:10.1186/1750-1172-1-17. PMC 1513194. PMID 16722557. 
  10. ^ a b c "Megaloblastic Anemia: Overview - eMedicine Hematology". Retrieved 2009-02-07. 
  11. ^ Kaikov, Y.; L. D. Wadsworth, C. A. Hall and P. C. J. Rogers (1991). "Transcobalamin II deficiency: Case report and review of the literature". European Journal of Pediatrics (European Journal of Pediatrics): Volume 150, Number 12, 841–843,. doi:10.1007/BF01955004. Retrieved 2 March 2011. 
  12. ^ Hall, C. A. (November 1975). "Transcobalamins I and II as natural transport proteins of vitamin B12.". J. Clin. Invest. 56 (5): 1125–1131. doi:10.1172/JCI108187. PMC 301974. PMID 1184739. 
  13. ^ "Folate-deficiency anemia". National Center for Biotechnology Information. U.S. National Library of Medicine. reviewed January 31, 2010. Retrieved 2 March 2011. 
  14. ^ Shahidi, Nasrollah T.; Diamond, Louis K; Shwachman, Harry (October 1961). "Anemia associated with protein deficiency". The Journal of Pediatrics. Elsevier Inc. Retrieved 28 March 2011. 
  15. ^ Vorvick, MD, Linda (March 14, 2009). "Scurvy". Medline Plus. U.S. National Library of Medicine. Retrieved 1 March 2011. 
  16. ^ Hillman, RS; Ault, KA; Leporrier, M; Rinder, HM. (2011). Hematology in Clinical Practice (5th ed.). McGraw-Hill. ISBN 978-0-07-162699-6. 
  17. ^ Longo, D; Fauci, AS; Kasper, DL; Hauser, SL; Jameson, JL; Loscalzo J. (2012). Harrison's Principles of Internal Medicine (18th ed.). McGraw-Hill. ISBN 978-0-07174889-6. 
  18. ^ Haldeman-Englert, C; Zieve, D. (version date August 4, 2011). "Bassen-Kornzweig syndrome". Pub Med Health. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  19. ^ Turgeon, Mary (2005). "8". Clinical Hematology: Theory and Procedures (4th ed.). Philadelphia: Lippincott Williams & Wilkins. p. 117. ISBN 0-7817-5007-5. 
  20. ^ Online 'Mendelian Inheritance in Man' (OMIM) 141800
  21. ^ Online 'Mendelian Inheritance in Man' (OMIM) 141850
  22. ^ "Alpha thalassemia". Genetics Home Reference. U.S. National Library of Medicine. February 27, 2011. Retrieved 3 March 2011. 
  23. ^ "Anemia of Chronic Disease". Iron Disorders Institute. 2009. Retrieved 3 March 2011. 
  24. ^ "Anemia in Kidney Disease and Dialysis". The National Kidney and Urologic Diseases Information Clearinghouse. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. October 2008. Retrieved 28 March 2011. 
  25. ^ Widness JA (November 2008). "Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity". Neoreviews 9 (11): e520. doi:10.1542/neo.9-11-e520. PMC 2867612. PMID 20463861. 
  26. ^ "Anemia of prematurity". Retrieved 2010-05-31. 
  27. ^ Aplastic anemia at Mount Sinai Hospital
  28. ^ [1] at Mount Sinai Hospital
  29. ^ "Hemolytic Anemia: Overview - eMedicine Hematology". Retrieved 2009-02-07. 
  30. ^ "Beta thalassemia". Genetics Home Reference. U.S. National Library of Medicine, NIH. March 13, 2011. Retrieved 21 March 2011. 
  31. ^ Tchernia, Gilbert; Delauney, J (June 2000). "Diamond–Blackfan anemia". Orpha.net. Retrieved 1 January 2010. 
  32. ^ Cmejla R, Cmejlova J, Handrkova H, et al. (February 2009). "Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond–Blackfan anemia". Hum. Mutat. 30 (3): n/a. doi:10.1002/humu.20874. PMID 19191325. 
  33. ^ "Congenital dyserythropoietic anemia". Genetics Home Reference. U.S. National Library of Medicine, National Institutes of Health. Reviewed July 2009. Retrieved 22 March 2011. 
  34. ^ Dhaliwal, Gurpreet; Cornett, Patricia, Tierney, Lawrence (2004). "Hemolytic Anemia". American Family Physician. 2004 Jun 1;69(11):2599-2607. American Family of Family Physicians. Retrieved 28 March 2011. 
  35. ^ "hemoglobinopathy" at Dorland's Medical Dictionary
  36. ^ Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704-712.
  37. ^ Hemoglobinopathies and Thalassemias
  38. ^ "Sickle Cell Trait and Other Hemoglobinopathies and Diabetes: Important Information for Physicians". National Diabetes Information Clearinghouse. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. November 2008. Retrieved 3 March 2011. 
  39. ^ Reviewed by Vorvick, Linda J.; Chen, Yi-Bin (Reviewed January 31, 2010). "Hemolytic anemia". Pub Med Health. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 24 March 2011. 
  40. ^ a b Turgeon, Mary Louise (2004). "12". Clinical Hematology (4th ed.). Lippincott Williams & Wilkins. p. 161. ISBN 0-7817-5007-5. 
  41. ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 625. ISBN 0-7216-0187-1. 
  42. ^ Tavares, Simone; Sills, Richard (January 3, 2011). "Pediatric Hereditary Elliptocytosis and Related Disorders". eMedicine. Retrieved 28 March 2011. 
  43. ^ Yawata, Yoshihito (2003). Cell membrane: the red blood cell as a model. Wiley-VCH. p. 227. Retrieved 11 April 2011. 
  44. ^ "Cold Agglutinin Disease: Overview - eMedicine Pediatrics: General Medicine". Retrieved 2009-02-07. 
  45. ^ "Paroxysmal cold hemoglobinuria (PCH) e". Medline Plus. U.S. Department of Health and Human Services, National Institutes of Health. March 28, 2010. Retrieved 28 March 2011. 
  46. ^ "Hemolytic Uremic Syndrome in Children". National Kidney and Urologic Diseases Information Clearinghouse. National Institutes of Health of the U.S. Department of Health and Human Services. January 2009. Retrieved 4 March 2011. 
  47. ^ Rijksen, G; Staal, G E. (August 1978). "Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties.". J. Clin. Invest. (National Center for Biotechnology Information, U.S. National Library of Medicine) 62 (2): 294–301. doi:10.1172/JCI109129. PMC 371766. PMID 27532. 
  48. ^ Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (2007). "Trauma: Critical Care". Google books. CRC press. p. 962. Retrieved 1 April 2011. 
  49. ^ Rivella, S. (May 2009). "Ineffective erythropoiesis and thalassemias". Curr. Opin. Hematol. (National Center for Biotechnology Information, U.S. National Library of Medicine) 16 (3): 187–94. doi:10.1097/MOH.0b013e32832990a4. PMID 19318943. 
  50. ^ "Ineffective Erythropoiesis". The New England Journal of Medicine. September 13, 1962. Retrieved 22 March 2011. 
  51. ^ "Hematopathology". 
  52. ^ "NINDS Neuroacanthocytosis Information Page". National Institute of Neurological Disorders and Stroke. National Institutes of Health. March 16, 2009. Retrieved 11 April 2011. 
  53. ^ "CHOREOACANTHOCYTOSIS; CHAC". Online Mendelian Inheritance in Man. Johns Hopkins University. Retrieved 11 April 2011. 
  54. ^ "Chorea-acanthocytosis". Genetic Home Reference. U.S. National Library of Medicine, National Institutes of Health. May 2008. Retrieved 11 April 2011. 
  55. ^ Online 'Mendelian Inheritance in Man' (OMIM) 266200
  56. ^ Cherif-Zahar, B.; Raynal, V., Le Van Kim, C, D'Ambrosio, AM, Bailly, P., Cartron, JP and Colin, Y. (April 6, 2011). "Structure and expression of the RH locus in the Rh-deficiency syndrome". Blood. Blood Journal. Retrieved 7 April 2011. 
  57. ^ Caudill JS, Imran H, Porcher JC, Steensma DP (October 2008). "Congenital sideroblastic anemia associated with germline polymorphisms reducing expression of FECH". Haematologica 93 (10): 1582–4. doi:10.3324/haematol.12597. PMID 18698088. 
  58. ^ Sideroblastic Anemias: Anemias Caused by Deficient Erythropoiesis at Merck Manual of Diagnosis and Therapy Professional Edition
  59. ^ "Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3 -- Allen et al. 60 (6): 1056 -- American Journal of Tropical Medicine and Hygiene". Retrieved 2008-02-26. 
  60. ^ "Spur-cell hemolytic anemia in severe alcoholic cirrhosis". Journal of the American Society of Hematology. The American Society of Hematology. January 1, 2003. Retrieved 10 April 2011. 
  61. ^ Ralser, Markus; Heeren, Gino; Breitenbach. Michael; Lehrach, Hans; Krobitsch, Sylvia (December 20, 2006). "Triose Phosphate Isomerase Deficiency Is Caused by Altered Dimerization–Not Catalytic Inactivity–of the Mutant Enzymes". PLoS ONE (National Center for Biotechnology Information, U.S. National Library of Medicine) 1: e30. doi:10.1371/journal.pone.0000030. PMC 1762313. PMID 17183658. 
  62. ^ "Autoimmune Hemolytic Anemia". The Merck Manuals: Online Medical Library. Merck Sharp and Dohme. Retrieved 25 March 2011. 
  63. ^ "Hematologic (Blood) Cancers". Centers for Disease Control and Prevention. Retrieved 25 January 2011. 
  64. ^ McPhee, Stephen; Ganong, William (2003). "Chapter 5: Neoplasia". Pathophysiology of Disease (5th ed.). New York: Lange Medical Books/McGraw-Hill. pp. 106 – 110. ISBN 0-07-144159-X. 
  65. ^ "Blood Cancers: Leukemia, Lymphoma, and Myeloma". Centers for Disease Control and Prevention. Retrieved 5 April 2011. 
  66. ^ "non-Hodgkin lymphomas" at Dorland's Medical Dictionary
  67. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  68. ^ a b [2] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues. IARC Press: Lyon 2001
  69. ^ Elaine Sarkin Jaffe, Nancy Lee Harris, World Health Organization, International Agency for Research on Cancer, Harald Stein, J.W. Vardiman (2001). Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors 3. Lyon: IARC Press. ISBN 92-832-2411-6. 
  70. ^ Mackey AC, Green L, Liang LC, Dinndorf P, Avigan M (February 2007). "Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease". J. Pediatr. Gastroenterol. Nutr. 44 (2): 265–7. doi:10.1097/MPG.0b013e31802f6424. PMID 17255842. 
  71. ^ O’Connor,, Owen A.; Vose, Julie M. (March 2008). "Getting The Facts: Indolent Follicular Lymphoma". Lymphoma Research Foundation. Retrieved 2 April 2011. 
  72. ^ Storey, Rowland; Gatt, Marcell, Bradford, Ian (January 6, 2009). "Mucosa associated lymphoid tissue lymphoma presenting within a solitary anti-mesenteric dilated segment of ileum: a case report". Journal of Medical Case Reports. BioMed Central. Retrieved 2 April 2011. 
  73. ^ "Leukemia - Chronic Lymphocytic - CLL". Cancer.Net. American Society of Clinical Oncology (ASCO). December 2, 2010. Retrieved 2 April 2011. 
  74. ^ Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 283. ISBN 0-7817-5007-5. 
  75. ^ "Waldenström Macroglobulinemia". Mayo Clinic. Mayo Foundation for Medical Education and Research. Retrieved 4 April 2011. 
  76. ^ Franco,, Vito; Florena, Ada Maria; Iannitto, Emilio (November 21, 2002). "Splenic marginal zone lymphoma". Journal of the American Society of Hematology. American Society of Hematology. Retrieved 4 April 2011. 
  77. ^ Jones, Dan; Ballestas, Mary E.; Kaye, Kenneth M.; Gulizia, James M.; Winters, Gayle L.; Fletcher, Jonathan; Scadden, David T.; Aster, Jon C. (August 13, 1998). "Primary-Effusion Lymphoma and Kaposi's Sarcoma in a Cardiac-Transplant Recipient". The New England Journal of Medicine. Massachusetts Medical Society. Retrieved 4 April 2011. 
  78. ^ Chan SM, George T, Cherry AM, Medeiros BC (February 2009). "Complete remission of primary plasma cell leukemia with bortezomib, doxorubicin, and dexamethasone: a case report". Cases J 2 (1): 121. doi:10.1186/1757-1626-2-121. PMC 2644294. PMID 19192311. 
  79. ^ Kim SJ, Kim J, Cho Y, Seo BK, Kim BS (May 2007). "Combination chemotherapy with bortezomib, cyclophosphamide and dexamethasone may be effective for plasma cell leukemia". Jpn. J. Clin. Oncol. 37 (5): 382–4. doi:10.1093/jjco/hym037. PMID 17538191. 
  80. ^ Gassmann W,; Löffler H. (1995). "Acute megakaryoblastic leukemia". Leuk. Lymphoma (National Center for Biotechnology Information, U.S. National Library of Medicine). 18 Suppl 1: Leukemia and Lymphoma. 18 Suppl 1:69–73. doi:10.3109/10428199509075307. PMID 7496359. 
  81. ^ Lowenberg, M.D., Bob; Downing M.D., James R., Burnett M.D., Alan (September 30, 1999). "Acute myeloid leukemia". The New England Journal of Medicine. Massachusetts Medical Society. p. 1051 Volume 341 Number 14. Retrieved 8 March 2011. 
  82. ^ Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981). "Deficiency of protein C in congenital thrombotic disease". J. Clin. Invest. 68 (5): 1370–3. doi:10.1172/JCI110385. PMC 370934. PMID 6895379.