List of musical comedians

This list is limited to comedians who also played an instrument onstage.

• David "Stringbean" Akeman - banjo
• Steve Allen - piano
• Woody Allen - clarinet
• Axis of Awesome - guitar, keyboard, vocals
• David Baddiel - piano, guitar
• Bo Burnham - piano, guitar
• Bill Bailey - various - most often guitar, keyboard, theremin
• Heywood Banks - multiple
• Pete Barbutti - piano, accordion ("cordine"), trumpet
• Tom Basden - guitar
• The Bedroom Philosopher - guitar, accordion
• Mitch Benn - guitar, vibraphone, spoons
• Jack Benny - violin
• Mike Birbiglia - guitar
• Jack Black - guitar, saxaboom
• Dennis Blair - guitar
• Victor Borge - piano
• Albert Brooks - piano
• John Bytheway - guitar
• Charlie Callas - drums
• Rodney Carrington - guitar
• Jasper Carrott - guitar
• Johnny Carson - drums
• Dana Carvey - piano, guitar, drums
• Tommy Chong - guitar
• Chris Cohen - guitar, vocals
• Billy Connolly - banjo, guitar
• Jonathan Coulton - guitar
• James Davies - Piano, Ukulele
• Les Dawson - piano
• Jessica Delfino - guitar, rape whistle, autoharp, flying v ukulele
• Doug Anthony All Stars - guitar, vocals
• Da Vinci's Notebook - Vocals
• Jimmy Durante - piano
• Kevin Eldon - guitar
• Lee Evans - piano
• Jimmy Fallon - guitar
• Wayne Federman - ukulele, piano, guitar, drums
• Graham Fellows (as "John Shuttleworth") - keyboard
• Michael Flanders - piano
• Flight Of The Conchords* - guitars, various
• The Folksmen - guitar, bass, mandolin, banjo
• George Formby* - ukulele
• Zach Galifianakis - piano
• Garfunkel and Oates - guitar, flute, piano, maracas, and ukulele
• Paul Garner - piano
• Kyle Gass - guitar
• Ricky Gervais - Guitar
• George Gobel - Guitar
• Rich Hall - keyboard
• Andrew Hansen - piano
• Hard n Phirm - numerous instruments
• Tim Hawkins - guitar, piano
• Ed Helms - piano
• Rainer Hersch - piano
• Harry Hill - 'hornophone' (one of his own creations)
• Homer and Jethro - guitar, banjo
• Hoosier Hot Shots - various
• Eric Idle*(as Monty Python) - guitar, piano
• Eddie Izzard - piano
• Penn Jillette - bass
• Spike Jones - percussion
• Mickey Katz - clarinet
• Boris Khaykin - rapper, beats, guitar, piano, synth
• Sam Kinison - piano, guitar, drums
• Robert Klein - harmonica
• Jon Lajoie - guitar
• Hugh Laurie - piano, guitar, harmonica
• Stewart Lee - guitar
• Tom Lehrer - piano
• Jerry Lewis - drums
• The Lonely Island - various
• Matt Lucas (as George Dawes) - drums
• Stephen Lynch - guitar
• Demetri Martin - guitar, glockenspiel, piano, harmonica, tambourine, toy bells, keyboard, ukelele
• Steve Martin - banjo
• Chico Marx - piano
• Groucho Marx - guitar
• Harpo Marx - harp, piano
• Taylor Mason - piano
• Kate Micucci - ukulele
• Tim Minchin - piano, guitar
• Dudley Moore - piano
• Dermot Morgan - guitar
• Kevin Nealon - guitar, banjo
• The New Main Street Singers - guitars, mandolins, tambourine
• Conan O'Brien - guitar
• David O'Doherty - keyboard
• Ardal O'Hanlon - keyboard
• Rob Paravonian - guitar
• Geraldine Quinn - guitar
• Raymond and Scum - guitar
• Howard Read - ukulele
• Rhett and Link - guitar, recorder, harmonica, bass harp
• Mark Russell - piano
• Bob Saget - guitar
• Andy Samberg - rapping/Singing
• Sammy J - piano
• Adam Sandler - guitar, drums, ukulele
• Peter Sellers - ukulele
• Scared Weird Little Guys - Various Instruments
• Akiva Schaffer - rapping/Singing
• Ronnie Schell - piano
• Helge Schneider - piano, trumpet, guitar, drums, clarinet/saxophone
• Peter Sellers - drums, ukulele
• Gene Sheldon - Banjo
• Frank Skinner - banjo, ukelele
• Brendon Small - guitar
• Dick Smothers - bass
• Tommy Smothers - guitar
• Spinal Tap - guitar, bass, drums, keyboard
• Ray Stevens - piano, banjo
• Donald Swann - piano
• Jorma Taccone - various instruments
• Jim Tavare - bass
• Judy Tenuta - accordion
• Tenacious D - guitar and vocals
• Nick Thune - guitar
• Tripod - guitar and vocals
• Carla Ulbrich - guitar
• Tracey Ullman - guitar
• Uncle Floyd (Floyd Vivino) - piano
• Daniel Lawrence Whitney - guitar
• Tim Wilson - guitar
• Dennis Wolfberg - guitar
• Victoria Wood - piano
• Frank Woodley - guitar
• Steven Wright - guitar
• "Weird Al" Yankovic - accordion
• Henny Youngman - violin