The U.S. city of San Antonio, Texas is home to 93 high-rises, 8 of which are skyscrapers that stand at least 328 feet (100 m) feet tall. The tallest structure in the city, excluding radio antennae, is the Tower of the Americas. standing 750 feet (229 m) tall. Completed in 1968, it is the tallest structure in Texas (excluding radio antennae) south of Houston, the second tallest observation tower in the United States, and third tallest in the Western Hemisphere. The second tallest structure and tallest building in the city is the Marriott Rivercenter. The history of skyscrapers in San Antonio began with the construction of the Tower Life Building (originally the Smith-Young Tower) in 1928, which is often regarded as the first skyscraper in the city. One skyscraper, the Frost Bank Headquarters, has been proposed. It is estimated to rise to up to 520 feet (158 m) tall if built as proposed, which would make it the second tallest structure and tallest office building in city upon completion around 2019.
This list ranks San Antonio high-rises that stand at least 328 feet (100 m) tall, based on standard height measurement. This includes spires and architectural details. An equal sign (=) following a rank indicates the same height between two or more buildings. The "Year" column indicates the year in which a building was completed.