Liver X receptor alpha

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Nuclear receptor subfamily 1, group H, member 3
Protein NR1H3 PDB 1uhl.png
PDB rendering based on 1uhl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NR1H3 ; LXR-a; LXRA; RLD-1
External IDs OMIM602423 MGI1352462 HomoloGene21165 IUPHAR: NR1H3 ChEMBL: 2808 GeneCards: NR1H3 Gene
RNA expression pattern
PBB GE NR1H3 203920 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10062 22259
Ensembl ENSG00000025434 ENSMUSG00000002108
UniProt Q13133 Q9Z0Y9
RefSeq (mRNA) NM_001130101 NM_001177730
RefSeq (protein) NP_001123573 NP_001171201
Location (UCSC) Chr 11:
47.27 – 47.29 Mb
Chr 2:
91.18 – 91.2 Mb
PubMed search [1] [2]

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).[1][2]

Expression[edit]

miRNA hsa-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA hsa-miR-613.[3]

Function[edit]

The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs) and regulate expression of target genes containing LXR response elements.[4][5]Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.[6]

Interactions[edit]

Liver X receptor alpha has been shown to interact with EDF1[7] and Small heterodimer partner.[8]

References[edit]

  1. ^ Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". J. Biol. Chem. 271 (16): 9189–92. doi:10.1074/jbc.271.16.9189. PMID 8621574. 
  2. ^ Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes Dev. 9 (9): 1033–45. doi:10.1101/gad.9.9.1033. PMID 7744246. 
  3. ^ http://mend.endojournals.org/content/25/4/584.abstract
  4. ^ Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K (June 2009). "Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice". J. Clin. Invest. 119 (6): 1626–37. doi:10.1172/JCI35288. PMC 2689129. PMID 19436111. 
  5. ^ "Entrez Gene: nuclear receptor subfamily 1". 
  6. ^ Gupta DS, Kaul D, Kanwar AJ, Parsad D (January 2010). "Psoriasis: crucial role of LXR-alpha RNomics.". Genes and Immunity 11. doi:10.1038/gene.2009.63. 
  7. ^ Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021. 
  8. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.