In the 1960s, he established himself as one of the most recognisable and popular stars of former Yugoslav cinema.
In the 1990s, he and his son Dragan Samardžić founded a film production company. Despite break-up of Yugoslavia and UN sanctions against Serbia, the company made many popular and commercial successful films.
In August 1995, he received Life Achievement Award "Pavle Vujisić" for his roles in Yugoslav cinematography.
He has been married to Mirjana Samardžić since 1960. Nicknamed Smoki, he has been credited as Ljubisa Samardjic, Luba Samardy, Ljubisa Samardzic-Smoki, and Smoki Samardì.