In 1967 the site became the area's main station for 625 line colour UHF TV, starting with just BBC Two in June of that year. By this time, it was policy to co-site all UHF TV services at the same site, and by 1973 Llanddona was broadcasting BBC One, BBC Two and ITV on UHF. S4C was added later in 1982 in time for its launch.
Though 405-line TV was discontinued in the UK in 1985, it seems that Llanddona shut down its VHF TV a year early.
In the late 1990s, digital TV transmitters were added, carrying all six national multiplexes.
In 2006, digital radio transmitters were added for the BBC's national multiplex and also Digital One.
On Wednesday 21 October 2009, the Llanddona group of transmitters underwent the first stage of the Digital Switchover and on Wednesday 18 November 2009, analogue television was finally turned off from Llanddona and its group of transmitters as it underwent the second stage of the Digital Switchover. Whilst the old analogue channels were in the UK UHF C/D aerial group, the new DVB channels are now spread over into the E group (presumably to avoid co-channel interference with Winter Hill transmitter), meaning that some customers may need to replace their aerial to get optimum reception.
Freeview HD started transmitting using the BBC B multiplex on channel 53 in July 2010.
Llanddona was the site of the first TV, VHF radio, digital TV and digital radio broadcasts for the area.
The coverage area consists of the majority of Anglesey, and a wide range of other parts of the North West Wales coast. As with the service areas of other transmitters in North Wales, such as the Moel-y-Parc transmitting station, signal overspill from transmitters in North West England and Greater Manchester means that strong radio and television signals from that region (BBC North West and ITV Granada) can be received in North Wales, and strong Welsh signals can be received in North West England also. In the days of analogue TV, some people who received signals from the Llanddona transmitter, but who had no interest in S4C (a Welsh speaking channel) were known to erect a second aerial and receive Channel 4 from Winter Hill instead.
"The Big Tower" claim that 405-line television from Llanddona started in January 1958, and the entrance plaque to the transmitter building certainly agrees that the mast and its building were built in 1958. Oddly, BBC research report 1963-50 does not mention a start date though it does point out that co-channel interference (presumably from Divis in Northern Ireland, about 180 km to the northwest across the Irish Sea) was "severe". This caused the transmitter's useful service area to be smaller than planned, and forced the building of the Holyhead relay.
"405 Alive" counter-claim a very precise date of 15 May 1962 for the start of 405-line television.
The BBC Two analogue signal was switched off after 32 years of service, and BBC One analogue was moved to channel 63. Multiplex 1 on channel 50 was also discontinued. The new "BBC A" multiplex took over on channel 57 which had just been vacated by BBC One analogue with its full post-DSO ERP of 20 kW. BBC A is an expanded version of the BBC's multiplexes 1 and B (with several channels, such as BBC Four and radio stations temporarily available on both BBC multiplexes).
All the remaining analogue TV was discontinued, and the new post-DSO multiplexes took over their frequencies plus a couple of new ones. Frequencies above 800 MHz were not re-used as these will be reassigned to 4G mobile phone services.
As a side-effect of frequency-changes elsewhere in the region to do with clearance of the 800 MHz band for 4G mobile phone use, Llanddona's "Arqiva B" multiplex was moved from channel 50 to channel 40, and "D3&4" on channel 60 gained a negative frequency offset.