Lofendazam

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Lofendazam
Lofendazam.svg
Systematic (IUPAC) name
8-chloro- 1-phenyl- 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one
Clinical data
Legal status
?
Identifiers
CAS number 29176-29-2 YesY
ATC code None
PubChem CID 71709
ChemSpider 64759 YesY
UNII V7O53S50SN YesY
Chemical data
Formula C15H13ClN2O 
Mol. mass 272.73
 YesY (what is this?)  (verify)

Lofendazam[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. [2][3]

Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[4]

See also[edit]

References[edit]

  1. ^ DE Patent 1929656
  2. ^ Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Liebigs Annalen der Chemie, 1995. (10):1861-1869.
  3. ^ Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Organic Magnetic Resonance, 1981. 15(4):394-398
  4. ^ J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. ISBN 978-3-540-58961-7