Lomefloxacin

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Lomefloxacin
Lomefloxacin.svg
Lomefloxacin ball-and-stick.png
Systematic (IUPAC) name
(RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Clinical data
Trade names Maxaquin
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a600002
Legal status
?
Pharmacokinetic data
Protein binding 10%
Half-life 8 hours
Identifiers
CAS number 98079-51-7 YesY
ATC code J01MA07 S01AE04
PubChem CID 3948
DrugBank DB00978
ChemSpider 3811 YesY
UNII 9VC7S3ZXXB YesY
KEGG D02318 YesY
ChEBI CHEBI:116278 YesY
ChEMBL CHEMBL561 YesY
Chemical data
Formula C17H19F2N3O3 
Mol. mass 351.348 g/mol
 YesY (what is this?)  (verify)

Lomefloxacin hydrochloride (sold under the following brand names in English speaking countries Maxaquin, Okacyn, Uniquin) is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.[1]

October 2008 the FDA added the following black box warning to the product insert for Maxaquin: Lomefloxacin is unique in that it forms a magnesium chelate with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules.

See also[edit]

References[edit]

  1. ^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy 47 (Suppl 3): 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.