It consists of the part of the City of London east of Wonderland Road North and Wharncliffe Road, north of Oxford Street West and the Thames River and west of Highbury Avenue North. The district includes the University of Western Ontario and Victoria, University, and St. Joseph's Hospitals. Wonderland Road, Oxford Street, Wharncliffe Road, and south branch of the Thames River form its western boundary with the district of London West, Highbury Avenue and the south branch of the Thames its eastern and southern boundaries with London—Fanshawe, and the north city limit its boundary with Perth—Middlesex riding to the north.
The riding was created in 1996 as "London—Adelaide" from parts of London East and London—Middlesex ridings. It was renamed "London North Centre" in 1997.
The election was called on October 22, 2006 with polling day falling on November 27.
The election result presented a major breakthrough for the Green Party, tripling its previous showing in the general election and placing slightly ahead of the candidate of the governing Conservative Party. The vote for party leader Elizabeth May was over five times the 4.5% national popular vote in the preceding federal election.