Lonidamine

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Lonidamine
Lonidamine.svg
Systematic (IUPAC) name
1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
Clinical data
Legal status ?
Identifiers
CAS number 50264-69-2 YesY
ATC code L01XX07
PubChem CID 39562
UNII U78804BIDR YesY
KEGG D07257 YesY
Chemical data
Formula C15H10Cl2N2O2 
Mol. mass 321.158 g/mol
 YesY (what is this?)  (verify)

Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.[1]

Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.[1]

Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours.[2]

A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill.[3]

References[edit]

  1. ^ a b Pelicano H, Martin DS, Xu RH, Huang P (August 2006). "Glycolysis inhibition for anticancer treatment". Oncogene 25 (34): 4633–4646. doi:10.1038/sj.onc.1209597. PMID 16892078. 
  2. ^ Prabhakara S, Kalia VK (August 2008). "Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine". Indian J. Med. Res. 128 (2): 140–8. PMID 19001677. 
  3. ^ Tash, Joseph (July 2008). "A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose". Biology of Reproduction 78 (6): 1127–1138. doi:10.1095/biolreprod.106.057810. PMID 18218612.