Lorenzo Leonbruno (20 March 1480–1537) was an Italian painter of the Renaissance period, active mainly in his native Mantua.
By 1511, he is receiving a stipend from the duke Francesco IV Gonzaga. He was a pupil of the painter Lorenzo Costa. He painted a St Jerome found in the Ducal palace. In 1521, he briefly traveled to Rome. He also worked as an architect and engineer. Giulio Romano is said to have painted over much of his fresco work for the duke of Mantua.