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Symbols LOR ; MGC111513
External IDs OMIM152445 MGI96816 HomoloGene68056 GeneCards: LOR Gene
RNA expression pattern
PBB GE LOR 207720 at tn.png
More reference expression data
Species Human Mouse
Entrez 4014 16939
Ensembl ENSG00000203782 ENSMUSG00000043165
UniProt P23490 P18165
RefSeq (mRNA) NM_000427 NM_008508
RefSeq (protein) NP_000418 NP_032534
Location (UCSC) Chr 1:
153.23 – 153.23 Mb
Chr 3:
92.08 – 92.08 Mb
PubMed search [1] [2]

Loricrin is a protein that in humans is encoded by the LOR gene.[1][2][3]


Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.[3]

Clinical significance[edit]

Mutations in the LOR gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.[3]

See also[edit]


  1. ^ Hohl D, Mehrel T, Lichti U, Turner ML, Roop DR, Steinert PM (May 1991). "Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins". J Biol Chem 266 (10): 6626–36. PMID 2007607. 
  2. ^ Yoneda K, Hohl D, McBride OW, Wang M, Cehrs KU, Idler WW, Steinert PM (Oct 1992). "The human loricrin gene". J Biol Chem 267 (25): 18060–6. PMID 1355480. 
  3. ^ a b c "Entrez Gene: LOR loricrin". 

Further reading[edit]