The oldest known reference to Losser dates from the tenth century. Originally, the village consisted of two separate parts. Both were almost completely destroyed when on 21 September 1665, troops from Münster set fire to them.
One of the town's oldest buildings is the Martinustoren (St. Martin's Tower), dating from around 1500 and the only remaining part of a church demolished in 1903.
A few kilometers west of De Lutte, close to the border with Oldenzaal, lies the Tankenberg, a hill the top of which (85 m) is the highest point in the province. (For myths of the Tankenberg, see Tanfana.)
The municipality's most important body of water is the river Dinkel.