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Loteprednol etabonate
Loteprednol etabonate.svg
Systematic (IUPAC) name
Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a606003
Pregnancy cat.
Legal status
CAS number 82034-46-6 YesY
ATC code S01BA14
PubChem CID 444025
DrugBank DB00873
ChemSpider 392049 N
KEGG D01689 YesY
Chemical data
Formula C24H31ClO7 
Mol. mass 466.951 g/mol
 N (what is this?)  (verify)

Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.

See also[edit]


  • Steward, R; et al. (November 1998). "Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5% for postoperative inflammation". J Cataract Surg 24: 1480–1489. 
  • Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274.