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Louis Dubertret was born on 18 June 1943 in Douai (France). He is an associate professor of medicine specializing in dermatology and cutaneous biology. He is currently the President of Fondation René Touraine.
- 1 Biography
- 2 Medical contributions
- 3 Scientific contributions
- 4 Involvement in international medical and scientific actions
- 5 Awards and distinctions
- 6 Bibliography
- 7 Notes
Louis Dubertret studied in Douai and Amiens (France) before entering the Paris Faculty of Medicine. In 1965 he was an extern and student of Maurice Tubiana in the cancer ward and of Fred Siguier, specialist in internal medicine.
In May 1968, he participated in a committee that published a document presenting some proposals to reform medical studies. Some of those proposals were used for the Orientation Law, proposed by Edgar Faure in November 1968.
In 1970, Louis Dubertret started his residency and discovered the importance of dermatological manifestations in internal medicine thanks to the professors Jean Hewitt and René Touraine. From 1972 to 1973, Louis Dubertret was associate assistant in experimental pathology at the Paris Faculty of Medicine. He wrote his thesis on psoriasis physiopathology and finished his residency in 1975.
In 1975, Louis Dubertret suggested to professor René Touraine to set up, within the dermatology department of Henri Mondor hospital, a research laboratory in dermatology. From 1975 to 1997, Louis Dubertret was an associate clinical director and an assistant professor in fundamental science at the Creteil Faculty of Medicine. In 1977, he became clinical director.
From 1976 to 1977, Louis Dubertret created a degree in cutaneous physiology. In 1982, he became Professor of Dermatology. He became also doctor of Parisian Hospitals.
From 1989 to 2009, he was a senior consultant in dermatology at the Saint-Louis hospital, which is a national reference in dermatology.
From 1987 to 1991, he was member of the National Council of Universities. In 1993, he became Director of a degree in cutaneous biology and pharmacology. From 1995 to 2005, he was responsible for the continuing medical education courses in Dermatology at the Entretiens de Bichat.
In September 2012, his academic functions ended and Louis Dubertret is now Emeritus Professor.
Healthcare – Therapeutic education
As senior consultant at the Saint-Louis hospital, Louis Dubertret set up dedicated outpatient consultations to assemble specific expertise on each kind of disease. In his department, dermatology is subdivided into dedicated outpatient consultations: consultation for psoriasis, consultation for melanoma, consultation for rare genetic skin diseases, consultation for contact allergies, consultation for photobiology, consultation for photo dermatology, … These consultations allow to assess the patient needs and to develop clinical, therapeutic and biological research.
In 1995, Louis Dubertret formalized a new medical technique to take charge of chronic diseases. This technique is composed of four steps: questioning, explanation, negotiation, and prescription. This technique allows for a global care of patients and since then, the patient-based medicine is the subject of a lot of publications.
Sabouraud Health Center
In 1993, with Edouard Couty and Pascal Reygagne, Louis Dubretret created the Sabouraud Health Center at the Saint-Louis hospital in Paris. Louis Dubertret is the president of this center that is specialized on skin and hair.
Cutaneous inflammation and psoriasis
Louis Dubertret and his team developed methods to study cutaneous inflammation in vitro and in vivo. First they developed histology methods to study the new functions of inflammatory skin cells. Then they optimized the technique of "suction blusters" and "skin chambers". With this technique, one can study in vivo human molecular and cellular events implicated in inflammatory reactions, particularly in psoriasis and its allergic reactions.
This quantitative and dynamic approach to the inflammation in vivo in humans allowed for the better understanding of psoriasis. In therapeutic research, Louis Dubertret coordinates several studies to evaluate anti psoriatic drugs. In 2005, the Fondation René Touraine, presided by Louis Dubertret, initiated in collaboration with eleven European countries the Psoriasis International Network, a network aimed to develop clinical and therapeutic research for psoriatic patients.
In 1997, Raymond Latarjet entrusts Louis Dubertret with the development of the French research on drugs activated by light: psoralen. Louis Dubertret coordinated the research activities of six fundamental research laboratories in photobiology to discover new photoactive molecules.
His works were rewarded by the Galien Prize in 1989.
Louis Dubertret was also elected President of the French Society of Photobiology in 1987. That same year, he was named as an expert in sun and skin matters to the French Health Ministry.
Organogenesis in vitro
With his team, Louis Dubertret demonstrated that cellular behavior is different in vivo and in vitro. He reconstructed in vitro the cellular environment met in vivo. With Eugène Bell, from MIT, he developed the concept of organogenesis in vitro and developed a human skin model composed of dermis and epidermis with normal or pathologic cells.
In 1983, thanks to this technique, the first world’s transplants of human skin entirely reconstructed were realized on 16 patients, burn or suffering from giant cutaneous malformations.
In 1987, the laboratory became a research unit of INSERM.
This work was recognized by the Parisian Award Claude-Bernard, which was given by former President Jacques Chirac in 1988, and by the Vermeil Medal of Paris.
From 1993 to 1996, Louis Dubertret developed the Skin Research Institute at the Saint-Louis Hospital with the help of public subventions and private donations, from Chanel and l’Oréal in particular. Louis Dubertret ran this institute until 2009.
The creation of the bio clinical research laboratory within the Saint-Louis Hospital by Louis Dubertret fits into the scheme of public/private collaborations. With research teams of l’Oreal, this laboratory works to a better understanding of healthy skin reactions to environmental stresses and strains and in particular of the molecular process of cutaneous ageing. In 2008, this laboratory became the L’Oreal Research Center.
Involvement in international medical and scientific actions
In 1991, Louis Dubertret created the Fondation René Touraine, an international non-governmental and non-profit organization that aims to develop partnerships between the actors of therapeutic progress in order to improve the quality of care in dermatology all around the world.
The Foundation encourages international collaborations with the allocation of research fellowships. The foundation organizes an annual international top-level symposium providing an up-to-date interdisciplinary approach on one different skin cell each year.
The Foundation fosters also two international networks centered on patient needs: the Genodermatoses Network and the Psoriasis International Network.
To make available updated therapeutic information on dermatology for practitioners and the general public, the Foundation has published for free on the web the French reference book in dermatology "Thérapeutique Dermatologique". This book is currently partially available in English under the name "Therapeutics in Dermatology".
In 2006, Louis Dubertret was elected President of the Board of the European Dermatology Forum (EDF), the European dermatology professors' association. During his presidency, the EDF achieved a harmonization of dermatology graduate studies in European medicine faculties.
Louis Dubertret is also an expert at the European Union Committee of Experts on Rare Diseases, as coordinator of the European project "Together Against Genodermatoses" co-funded by the European Union from 2008 to 2011.
Awards and distinctions
- 1988: Price Claude-Bernard for medical research of the city of Paris
- 1988: Vermeil Medal of the city of Paris
- 1989: Galien Award
- 1994: Award of "Order of Malta"
- Dubertret L. L’Homme et son programme. Denoël, Paris, 1975. Philosophical essay with a preface of Jean Fourastié.
- Dubertret L, Ed. Les Cancers cutanés. (Encyclopédie des cancers) Flammarion Médecine – Sciences, Paris, 1992, 583p.
- Dubertret L, Jeanmougin M. La peau et le soleil. Hermann, Paris, 1993, 116p.
- Dubertret L. Psoriasis. 1993 (published in French, English and Italia) ISED Éditions du Dôme.
- Dubertret L, Santus R, Morlière P. Ozone, Sun, Cancer: Molecular and Cellular Mechanisms, Prevention. Éditions Inserm, Paris, 1995, 288p.
- Dubertret L. contributions to 'L'ozone stratosphérique, Académie des Sciences, rapport Template:N°41, Lavoisier, Technique et Documentation, 1998
- Dubertret L. Psoriasis : de la clinique au traitement. Med’Com : Paris, 2004, 159 p / in English −2005, second edition 2008.
- Dubertret L. Psoriasis: Consensus and controversies, 2006 (online book with expert comments)
- Dubertret L. Soleil et santé, Rapports de l’Académie Nationale de Médecine, Lavoisier, 2006, 168 p.
- CHU Henri Mondor http://chu-mondor.aphp.fr/
- Faculté de médecine de Créteil http://medecine.u-pec.fr/
- Dubertret L. Patient-based medicine. JEADV 2006;20 (suppl 2): 73–6
- Dubertret L. La medicina centrada en el paciente: una revolution terapeutica. Acta Dermo- Sifilograficas 2007; 98:297–301
- Sabouraud Health Center http://www.centresabouraud.fr
- Michel L., Mencia-Huerta JM., Benveniste J., Dubertret L. : Biologie properties of LTB4 and paf-acether in vivo in human skin. J. Invest. Dermatol. 1987 Jun; 88(6): 675–81
- Biography of Louis Dubertret [archive] on Inserm website
- Dubertret L., Lebreton C., Touraine R. : Neutrophil studies in psoriatics: in vivo migration, phagocytosis and bacterial killing. J. Invest. Dermatol. 1982 Aug; 79(2): 74–8
- Psoriasis International Network http://www.psoriasis-international.org
- Dubertret L., Averbeck D., Zajdela F., Bisagni E., Moustacchi E., Touraine R., Latarjet R. : Photochemotherapy (PUVA) of psoriasis using 3-carbethoxypsoralen, a non-carcinogenic compound in mice. Br. J. Dermatol. 1997 Oct; 101(4):379-89
- Saiag P., Coulomb B., Lebreton C., Bell E., Dubertret L. : Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro. Science 1985 Nov 8; 230(4726): 669–72
- Bell E., Sher S., Hull B., Merrill C., Rosen S., Chamson A., Asselineau D., Dubertret L., Coulomb B., Lapiere C., Nusgens B., Neveux Y. : The reconstitution of living skin. J. Invest. Dermatol. 1983 Jul; 81 (1 Suppl): 2s–10s PMID 6306115
- Fondation René Touraine www.fondation-r-touraine.org
- Psoriasis : Consensus and controversies http://www.psoriasis-international.org/spip.php?page=livre_sommaire
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