Ombrédanne's primary field of research was development of new methods of surgery. In 1906 he was the first to describe the use of the pectoralis minor muscle for breast reconstruction following mastectomy. He also introduced transscrotal orchiopexy for surgical repair of an undescended testis.
In 1907, after two fatal anesthetic accidents, Ombrédanne created a prototype of an inhaler as a safe anesthetic device. It consisted of a tin container as reservoir that was fitted with felt to absorb ether, a graduated air inlet, and a respiratory reserve chamber. This device was tested successfully on over 300 patients, and design modifications were later made.
In 1929 Ombrédanne provided an early description of malignant hyperthermia, a condition he described as pallor with hyperthermia in newborns during anesthesia. The disorder was historically referred to as "Ombrédanne syndrome".
-  Plastic and Reconstructive Surgery: December 1983 - Volume 72 - Issue 6 - ppg 905-910
- Anesthesiology 2007 Louis Ombrédanne and Anesthesiology
- American Journal of Public Health Breast Implants