From her first recordings, Hoffsten's music and stage act have weaved together rock, folk and blues influences, while sometimes moving into R'n'B and jazz territory, unified by her earthy, slightly operatic singing style and driving, lean grooves. Like many blues singers she plays the harmonica as well, a recurrent element in her songs; she is arguably the most well-known and recognized female blues singer of contemporary Sweden. She has built a wide following in her native land, has won several awards and currently resides in Stockholm. She participated in Melodifestivalen 2013 with the song "Only the Dead Fish Follow the Stream".
In 1996, Louise was diagnosed with multiple sclerosis, but despite the complications and occasional depressions (mirrored in the book/record Blues), she continues to write, tour and perform music.