The seat is located in heavily Democratic New Orleans. No Republican had represented this district since Reconstruction. A Republican lawyer, Joe Lavigne, ran against Jefferson, while a number of Democrats have jumped into the race, include state Senator Derrick Shepherd of Marrero, former New Orleans City Councilman Troy Carter, and state Representative Karen Carter. In mid-October, the State Democratic party voted to endorse Karen Carter, the first time in recent memory that the state party has backed a challenger to its own incumbent Congressman.
Jefferson and Carter had finished in the top two places with 30% and 22% respectively, sending them to a run-off election where Jefferson defeated Carter 57% to 43% .