LA 500 begins near the parish line between Grant and Winn parishes at U.S. Route 167 (US 167). Though the intersection with US 167 is fully in Grant Parish, LA 500 travels east along the parish line for about 1.3 miles (2.1 km). The highway travels east through the Kisatchie National Forest, joining LA 472 for a short distance. After splitting from LA 472, LA 500 enters the small town of Georgetown, meeting US 165. It crosses US 165 and turns north at an intersection with LA 502, soon meeting LA 1230.
LA 500 then turns to the east, while a short signed section travels to the north to meet US 165. LA 500 then enters La Salle Parish, ending after a short distance at an intersection with US 84.
LA 500 is an undivided, two-lane road for its entire route. Before the 1955 Louisiana Highway renumbering, LA 500 was known as State Route 108. A portion of LA 500 between its junction with LA 502 and LA 1230 is an original piece of US 165. Therefore, LA 500 was also signed as State Route 14, and later State Route 2115.