- Aaron Lowe (born 1974), Canadian figure skater
- Adolph Lowe (1893-1995), German sociologist and economist
- Al Lowe (born 1942), American computer game programmer
- Alan Lowe (born 1961), Canadian politician
- Alex Lowe (1958-1999), American mountaineer
- Alex Lowe (born 1968), English actor
- Alice Lowe, English actress
- Andrea Lowe (born 1975), English actress
- Andrew Lowe (born 1959), Canadian scientist
- Ann Lowe (1898-1981), American fashion designer
- Annie Lowe, Australian suffragist
- Arthur Lowe (1915-1982), English actor
- Arvie Lowe, Jr. (born 1978), American actor
- Ben Lowe (born 1985), Australian rugby player
- Bernie Lowe (1917-1993), American music producer
- Bobby Lowe (1865-1951), American baseball player
- Bull Lowe (born 1895), American football player
- Caitlin Lowe (born 1985), American softball player
- Chad Lowe (born 1968), American actor
- Charles Lowe (1890-1953), English cricketer
- Charles Herbert Lowe (1920-2002), American biologist and herpetologist
- Chris Lowe (born 1949), British journalist
- Chris C. Lowe (born 1987), American basketball player
- Chris S. Lowe (born 1959), British musician with the Pet Shop Boys
- Crystal Lowe (born 1981), Canadian actress
- Cyril Lowe (1891-1983), British rugby player and flying ace
- Daisy Lowe (born 1989), English fashion model
- Darren Lowe (born 1960), Canadian ice hockey player
- Darren Lowe, American lacrosse player
- David Lowe (born 1960), British swimmer
- David Lowe, British composer
- David Lowe, British video game music composer
- David A. Lowe (born 1965), British footballer
- David G. Lowe, Canadian computer scientist
- David Perley Lowe (1823–1882), American lawyer and politician
- Derek Lowe (born 1973), MLB Pitcher, currently with the Braves and formerly of the Red Sox and Dodgers
- Doug Lowe (born 1942), Australian politician
- Douglas Lowe (1902-1981), British athlete
- Douglas Lowe (RAF officer), British air marshal
- Earl Lowe (born c. 1950), Jamaican musician
- Ed Lowe (businessman) (1920-1995), American inventor
- Ed Lowe (born 1946), American journalist
- Eddie Lowe (born 1925), English footballer
- Eddie Lowe (born 1960), Canadian football player
- Edmund Lowe (1890-1971), American actor
- Edward Lowe (c. 1690-c. 1724), English pirate
- Edward Clarke Lowe (1823-1912), English educator
- Edward Joseph Lowe (1825-1900), English botanist
- Edward T. Lowe Jr. (1880-1973), American film producer
- Emilio Lowe, a fictional archer in the anime Black Cat
- Enoch Louis Lowe (1820-1892), American politician
- Florence Leontine Lowe (1901-1975), American aviator
- Sir Francis Lowe, 1st Baronet (1852-1929), British politician
- Frank Lowe (1943-2003), American musician
- Frank Lowe, British businessman
- Fred Lowe, American weightlifter
- Gary Lowe (born 1934), American football player
- George Lowe (born 1915), English cricketer
- George Lowe (born 1958), American voice actor
- Georgina Lowe, British television producer
- Sir Gordon Lowe (1884-1972), British tennis player
- Graeme Lowe, band manager
- Graham Lowe, New Zealand rugby league football coach
- Harold Lowe (1882-1944), fifth officer on the RMS Titanic
- Harry Lowe (1886-1958), English footballer
- Harry James Lowe, Jr. (1922-1942), American sailor
- HF Lowe, English cricketer
- Sir Hudson Lowe (1769-1844), Anglo-Irish military officer and Governor of St Helena
- Ian Lowe, Australian scientist
- Jack Lowe, Sr. (1913-1980), American businessman
- Jack Lowe, Jr. (born 1939), American businessman
- Jaiman Lowe (born 1980), Australian rugby player
- James Lowe (1796-1866), British inventor
- James Lowe (born 1982), English cricketer
- James Lowe, English musician
- Janet Lowe, American writer
- Jemma Lowe (born 1990), British swimmer
- Jesse Lowe (1814-1868), American politician
- Jet Lowe, American photographer
- Jez Lowe, British musician
- Jim Lowe (born 1927), American musician
- Bl. John Lowe (1553-1586), English priest and martyr
- John Lowe (1899-1960), Canadian priest
- John Lowe (died 1995), British footballer
- John Lowe (born 1945), British darts player
- John Charles Lowe (born 1942), British musician
- Jonathan Lowe (born 1950), British philosopher
- Joseph Lowe (1845-1899), American saloon keeper
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- Karl Lowe (1796-1869), German composer
- Kate Lowe, English cricketer
- Keith Lowe (born 1970), British writer
- Keith Lowe (born 1985), English footballer
- Kendra Lowe (born 1962), English netball player
- Kenny Lowe (born 1961), English footballer
- Kevin Lowe (born 1959), Canadian hockey player
- Lisa Lowe, American academic
- Mark Lowe (born 1983), American baseball player
- Mary Johnson Lowe (1924-1999), American judge
- Megan Lowe, English cricketer
- Ming C. Lowe (born 1945), American artist
- Mundell Lowe (born 1922), American jazz guitarist
- Muriel Lowe, English cricketer
- Neil Lowe, English rugby player
- Nick A. Lowe (born 1979), American comic book editor
- Nick D. Lowe (born 1949), British singer
- Omare Lowe (born 1978), American football player
- Onandi Lowe (born 1974), Jamaican soccer player
- Paddy Lowe (born 1962), British racing engineer
- Paul Lowe (born 1936), American football player
- Pearl Lowe (born 1971), British musician
- Percy Lowe (1870-1948), English surgeon and ornithologist
- Peter Lowe (born 1938), British artist
- Phil Lowe, English rugby league footballer
- Rachel Lowe, British entrepreneur
- Ralph P. Lowe (1805-1883), American politician
- Rebecca Lowe (born 1980), British journalist
- Richard Barrett Lowe (1902-1972), Governor of American Samoa and Guam
- Richard Thomas Lowe (1802-1874) British naturalist
- Rob Lowe (born 1964), American actor
- Robert Lowe, American singer
- Robert Lowe, 1st Viscount Sherbrooke (1811-1892), British statesman
- Robson Lowe (1905-1997), British philatelist
- Ross Lowe (1928-1955), Canadian hockey player
- Rupert Lowe, British businessman
- Ruth Lowe (1914-1981), Canadian musician
- Ryan Lowe (born 1978), English footballer
- Sam Lowe (1867-1947), English cricketer
- Sammy Lowe (1918-1993), American musician
- Sean Lowe (born 1971), American baseball player
- Sid Lowe, British journalist
- Sidney Lowe (born 1960), American basketball coach
- Simon Lowe, British actor
- Stephen Lowe (clergyman), Bishop of Hulme
- Stephen Lowe (playwright) (born 1947), British playwright
- Steven Lowe, British writer
- Susan Lowe, American actress
- Ted Lowe (born 1920), British snooker commentator
- Thaddeus S. C. Lowe (1832-1913), American Civil War aeronaut, scientist and inventor
- Thomas Lowe (1812-1875), American politician
- Tiffany Anastasia Lowe (born 1972), daughter of musician Carlene Carter
- Titus Lowe (1877-1959), English-American clergyman
- Todd Lowe (born 1977), American actor
- Tom Lowe, American writer
- Tom E. Lowe (born 1975), British disc jockey
- Tom P. Lowe (born 1973), British singer
- Trent Lowe (born 1984), Australian cyclist
- Vaughan Lowe, British lawyer
- William M. Lowe (1842-1882), American politician
- William W. Lowe (1873-1945), English cricketer
- Woodrow Lowe (born 1954), American football player
- Zane Lowe (born 1973), British disc jockey
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