Lower motor neuron lesion

Lower motor neuron lesion
Classification and external resources
Lower motor neuron in red
DiseasesDB	22143

A lower motor neuron lesion is a lesion which affects nerve fibers traveling from the anterior horn of the spinal cord to the relevant muscle(s) -- the lower motor neuron.

One major characteristic used to identify a lower motor neuron lesion is flaccid paralysis - paralysis accompanied by muscle loss. This is in contrast to a upper motor neuron lesion, which often presents with spastic paralysis - paralysis accompanied by severe hypertonia.

Symptoms

• Muscle paresis or paralysis
• fibrillations
• fasciculations
• hypotonia or atonia- Tone is not velocity dependent.
• Areflexia or hyporeflexia -Along with deep reflexes even cutaneous reflexes are also decreased or absent
• Strength -weakness is limited to segmental or focal pattern, Root innervated pattern

The extensor Babinski reflex is usually absent. Muscle paresis/paralysis, hypotonia/atonia, and hyporeflexia/areflexia are usually seen immediately following an insult. Muscle wasting, fasciculations and fibrillations are typically signs of end-stage muscle denervation and are seen over a longer time period. Another feature is the segmentation of symptoms - only muscles innervated by the damaged nerves will be symptomatic.

Etiology

Most common causes of lower motor neuron injuries are trauma to peripheral nerves that sever the axons and poliomyelitis - a virus that selectively attacks ventral horn cells. Disuse atrophy of the muscle occurs i.e,shrinkage of muscle fibre finally replaced by fibrous tissue(fibrous muscle) Other causes include Guillain-Barré syndrome, C. botulism, polio, and cauda equina syndrome.

Differential Diagnosis

• Myasthenia gravis - synaptic transmission at motor end-plate is impaired
• Muscular dystrophy - contraction of muscle is impaired due to a cellular defect

See also

• Lower motor neuron
• Upper motor neuron
• Upper motor neuron lesion

External links

• http://library.med.utah.edu/neurologicexam/html/motor_anatomy.html#06