March 2, 1938 |
|Alma mater||University of Chicago (B.S.)
Harvard Medical School (M.D.)
|Awards||European Inventor of the Year (2006)|
Lubert Stryer (born March 2, 1938, in Tianjin, China) is the Mrs. George A. Winzer Professor of Cell Biology, Emeritus, at the Stanford University School of Medicine. His research over more than four decades has been centered on the interplay of light and life. In 2007, he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high density micro-arrays for genetic analysis, and authoring a biochemistry textbook.
Stryer received his B.S. degree from the University of Chicago in 1957 and his M.D. degree from Harvard Medical School. He was a Helen Hay Whitney Research Fellow in the Department of Physics at Harvard and then at the MRC Laboratory of Molecular Biology in Cambridge, England, before joining the faculty of the Department of Biochemistry at Stanford in 1963. In 1969, he moved to Yale to become Professor of Molecular Biophysics and Biochemistry, and in 1976, he returned to Stanford to head a new Department of Structural Biology.
Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularly Förster resonance energy transfer (FRET), to monitor the structure and dynamics of biological macromolecules. In 1967, Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor, as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules.
A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation. Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.
Stryer participated in developing light-directed, spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides. Light-directed combinatorial synthesis has been used by Stephen Fodor and coworkers at Affymetrix to make DNA arrays containing millions of different sequences for genetic analyses.
Starting in 1975, Stryer authored four editions of a textbook entitled Biochemistry.
- American Chemical Society Award in Biological Chemistry (Eli Lilly Award in Biological Chemistry, 1970)
- American Academy of Arts and Sciences (elected 1975)
- National Academy of Sciences (elected 1984)
- American Association for the Advancement of Science Newcomb Cleveland Prize (1992)
- Honorary Doctor of Science degree, University of Chicago, 1992
- Molecular Bioanalytics Award, German Society for Biochemistry and Molecular Biology, 2002
- American Philosophical Society (2006) 
- National Medal of Science (2006) 
- European Inventor of the Year 2006 in the category "Small and medium-sized enterprises" 
- Richard P. Haugland (Ph.D. 1970), founder of Molecular Probes, Inc. Currently President of the Starfish Country Home School Foundation in Chiang Mai, Thailand.
- Richard A. Mathies (postdoc), Dean of the College of Chemistry, University of California, Berkeley,
- Tobias Meyer (postdoc), now Professor, Department of Chemical and Systems Biology, Stanford University
- Stryer, L., 1968. Fluorescence spectroscopy of proteins. Science 1632:526-533
- Stryer, L.,and Haugland, R.P., 1967. Energy transfer: a spectroscopic ruler. Proc. Natl. Acad. Sci. USA 58:719-725
- Lakowicz, J.R., 2006. Principles of Fluorescence Spectroscopy (Springer, 3rd ed., p. 449)
- Fung,B., Hurley, J.B., and Stryer, L., 1981. Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc. Natl. Acad. Sci. USA 78:152-156
- Koch, K.-W., and Stryer, L., 1988. Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion. Nature 334:64-66
- <Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M., 1997. Molecular mechanics of calcium-myristoyl switches. Nature 389:198-202
- Burgoyne, R.D. and Weiss, J.L., 2001. The neuronal calcium sensor family of Ca2+-binding proteins. Biochem. J. 353:1-12.
- Fodor, S.P.A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., and Solas, D., 1991. Light-directed, spatially addressable parallel chemical synthesis. Science 251:767-773
- Fodor, S.P.A., Pirrung, M.C., Read, J.L., and Stryer, L., Array of oligonucleotides on a solid substrate. U.S. Patent No. 5,445,934. Issued August 29, 1995
- Latchman,D.S. (1995) Trends Biochem. Sci. 20:488.
- 1992 http://convocation.uchicago.edu/page/1990