Lucey–Driscoll syndrome

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Lucey–Driscoll syndrome
Classification and external resources
ICD-9 774.30
OMIM 237900
DiseasesDB 32677

Lucey–Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism. It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.

Cause[edit]

The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).

Genetics[edit]

Lucey–Driscoll syndrome has an autosomal recessive pattern of inheritance.

A defect in the UGT1A1-gene, also linked to Crigler–Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey–Driscoll syndrome.

External links[edit]