Lucila Gamero de Medina (June 12, 1873–January 23, 1964) was an important Honduran romantic novelist. She was one of the first women in Honduras to produce literary work. Born in Danlí, Honduras, she lived for many years in Mexico, where she published most of her work. Critic and writer Luis Marín Otero called her "the grand dame of Honduran letters".
Her literary output was a shining example of the late-Romantic period of Latin American literature. Love and family are major themes that occupy most of her narratives. Her best-known novel is Blanca Olmedo, a love story that directly criticizes the Honduran church and establishment at the time, an unprecedented step in Honduran literature. Blanca Olmedo is considered to be one of the most important Honduran novels of the early twentieth century. Gamero de Medina's novels are a staple of the literature curriculum in high schools and universities in Honduras. She wrote her autobiography in 1949.