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Lufenuron 200.svg
CAS number 103055-07-8 N
PubChem 71777
ChemSpider 64813 YesY
KEGG D08150 N
ChEBI CHEBI:39384 YesY
ATCvet code QP53BC01
Jmol-3D images Image 1
Molecular formula C17H8Cl2F8N2O3
Molar mass 511.15 g/mol
Melting point 174 °C (345 °F; 447 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Lufenuron the active ingredient in the veterinary flea control medication Program™, and one of the two active ingredients in the flea, heartworm, and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel™).

Lufenuron is stored in the animal's body fat and transferred to adult fleas through the host's blood when they feed. Adult fleas transfer it to their growing eggs through their blood, and to hatched larvae feeding on her excrement. It does not kill adult fleas.

Lufenuron, a benzoylurea pesticide, inhibits the production of chitin in insects. Without chitin, a larval flea will never develop a hard outer shell (exoskeleton). With its inner organs exposed to air, the insect dies from dehydration soon after hatching or molting (shedding its old, smaller shell).

Lufenuron is also used to fight fungal infections, since fungus cell walls are about ⅓ chitin[1] .

It has no toxic effects at any dosage on humans, other mammals or any animals not having hard shells (like shellfish and insects have).[citation needed]

Lufenuron is also sold as an agricultural pesticide for use against lepidopterans, eriophid mites, and western flower thrips. It is an effective antifungal in plants.

Because it is toxic to zooplankton,[2] Lufenuron was included in a biocide ban proposed by the Swedish Chemicals Agency. The ban was approved by the European Parliament on January 13, 2009.[3]


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