Lumican

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Lumican
Identifiers
Symbols LUM ; LDC; SLRR2D
External IDs OMIM600616 MGI109347 HomoloGene37614 GeneCards: LUM Gene
RNA expression pattern
PBB GE LUM 201744 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4060 17022
Ensembl ENSG00000139329 ENSMUSG00000036446
UniProt P51884 P51885
RefSeq (mRNA) NM_002345 NM_008524
RefSeq (protein) NP_002336 NP_032550
Location (UCSC) Chr 12:
91.5 – 91.51 Mb
Chr 10:
97.57 – 97.57 Mb
PubMed search [1] [2]

Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene.[1]

Function[edit]

Lumican is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin.[2] The glycosaminoglycan attached to the protein core is a keratin sulfate.

Lumican is a major keratan sulfate proteoglycan of the cornea but is ubiquitously distributed in most mesenchymal tissues throughout the body.[3] Lumican is involved in collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.[1] Corneal transparency is possible due to the exact alignment of collagen fibers by lumican (and keratocan) in the intrafibrillar space. Mice that have the lumican gene knocked out (Lum-/-) develop opacities of the cornea in both eyes and fragile skin.[4] Mice deficient in both lumican and fibromodulin develop severe tendinopathy (tendon pathology), revealing the importance of these SLRPs in the development of correctly sized and aligned collagen fibers in tendon.[5]

References[edit]

  1. ^ a b "Entrez Gene: LUM lumican". 
  2. ^ PMID:25701227
  3. ^ PMID:12975607
  4. ^ PMID:9606218
  5. ^ PMID:24443029

Further reading[edit]

  • Chakravarti S, Stallings RL, SundarRaj N et al. (1995). "Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22.". Genomics 27 (3): 481–8. doi:10.1006/geno.1995.1080. PMID 7558030. 
  • Grover J, Chen XN, Korenberg JR, Roughley PJ (1995). "The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.". J. Biol. Chem. 270 (37): 21942–9. doi:10.1074/jbc.270.37.21942. PMID 7665616. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Rada JA, Cornuet PK, Hassell JR (1996). "Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins.". Exp. Eye Res. 56 (6): 635–48. doi:10.1006/exer.1993.1081. PMID 8595806. 
  • Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH (2000). "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin.". Proteins 38 (2): 210–25. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID 10656267. 
  • Svensson L, Närlid I, Oldberg A (2000). "Fibromodulin and lumican bind to the same region on collagen type I fibrils.". FEBS Lett. 470 (2): 178–82. doi:10.1016/S0014-5793(00)01314-4. PMID 10734230. 
  • Pellegata NS, Dieguez-Lucena JL, Joensuu T et al. (2000). "Mutations in KERA, encoding keratocan, cause cornea plana.". Nat. Genet. 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. 
  • Neame PJ, Kay CJ, McQuillan DJ et al. (2000). "Independent modulation of collagen fibrillogenesis by decorin and lumican.". Cell. Mol. Life Sci. 57 (5): 859–63. doi:10.1007/s000180050048. PMID 10892350. 
  • Grover J, Liu CY, Kao WW, Roughley PJ (2001). "Analysis of the human lumican gene promoter.". J. Biol. Chem. 275 (52): 40967–73. doi:10.1074/jbc.M004134200. PMID 11016924. 
  • Naito Z, Ishiwata T, Kurban G et al. (2002). "Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests.". Int. J. Oncol. 20 (5): 943–8. doi:10.3892/ijo.20.5.943. PMID 11956587. 
  • Lu YP, Ishiwata T, Kawahara K et al. (2003). "Expression of lumican in human colorectal cancer cells.". Pathol. Int. 52 (8): 519–26. doi:10.1046/j.1440-1827.2002.01384.x. PMID 12366811. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Anderson NL, Polanski M, Pieper R et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
  • Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. 
  • Botella LM, Sanz-Rodriguez F, Sanchez-Elsner T et al. (2004). "Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression.". Matrix Biol. 22 (7): 561–72. doi:10.1016/j.matbio.2003.11.006. PMID 14996436. 
  • Vuillermoz B, Khoruzhenko A, D'Onofrio MF et al. (2004). "The small leucine-rich proteoglycan lumican inhibits melanoma progression.". Exp. Cell Res. 296 (2): 294–306. doi:10.1016/j.yexcr.2004.02.005. PMID 15149859. 
  • Köninger J, Giese T, di Mola FF et al. (2004). "Pancreatic tumor cells influence the composition of the extracellular matrix.". Biochem. Biophys. Res. Commun. 322 (3): 943–9. doi:10.1016/j.bbrc.2004.08.008. PMID 15336555. 
  • Li Y, Aoki T, Mori Y et al. (2004). "Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar.". Cancer Res. 64 (19): 7058–64. doi:10.1158/0008-5472.CAN-04-1038. PMID 15466200.