Lupe Anguiano (born 12 March 1929) is a civil rights activist known for her work on women's rights, the rights of the poor, and the protection of the environment. In 2007 she was designated a Women's History Month Honoree by the National Women's History Project.
She joined Our Lady of Victory Missionary Sisters from 1949 to 1964.  Anguiano was a national organizer for the United Farm Workers and the founder of the National Women's Employment and Education Model Program, which helped single female parents move beyond welfare poverty. She worked with Cesar Chavez, and in Michigan where she led the grape boycott of 1965.
She is a founding member of the National Women's Political Caucus, along with Gloria Steinem and Bella Abzug, and has worked on behalf of the Equal Rights Amendment. Anguiano was a delegate to the historic "First Women's Conference" in Houston in 1977, where she, Jean Stapleton, and Coretta Scott King read the "Declaration of American Women."
She currently volunteers at the California Coastal Protection Network, the Pacific Environment, and other environmental organizations. Her papers are housed at the UCLA Chicano Studies Research Center.
- 35th California Assembly District Woman of the Year
- "Honorees: 2010 National Women’s History Month". Women's History Month. National Women's History Project. 2010. Retrieved 14 November 2011.