Lymphoblast
Lymphoblasts are immature cells which typically differentiate to form mature lymphocytes. Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia (ALL), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.
The size is between 10 and 20 μm.[1]
Although commonly lymphoblast refers to a precursor cell in the maturation of leukocytes, the usage of this term is sometimes inconsistent. The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells."[2]. Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.
Lymphoblasts can be distinguished microscopically from myeloblasts by having fewer nucleoli than do myeloblasts, the nuclear chromatin is more condensed, and cytoplasmic granules are absent. [3]
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[edit] Additional images
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Blood cell lineage
They are 2.5 micrometres in size.
[edit] See also
[edit] References
- ^ Gillian Rozenberg (23 March 2011). Microscopic Haematology: A Practical Guide for the Laboratory. Elsevier Australia. pp. 106–. ISBN 9780729540728. http://books.google.com/books?id=a2fWUutmB64C&pg=PA106. Retrieved 29 May 2011.
- ^ CRC - Glossary L
- ^ Figure 12-14 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
[edit] External links
- lymphoblast at eMedicine Dictionary
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