Lymphocyte antigen 96

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Lymphocyte antigen 96
Protein LY96 PDB 1T2Z.png
Rendering based on PDB 1T2Z.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LY96 ; ESOP-1; MD-2; MD2; ly-96
External IDs OMIM605243 MGI1341909 HomoloGene9109 GeneCards: LY96 Gene
RNA expression pattern
PBB GE LY96 206584 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23643 17087
Ensembl ENSG00000154589 ENSMUSG00000025779
UniProt Q9Y6Y9 Q9JHF9
RefSeq (mRNA) NM_001195797 NM_001159711
RefSeq (protein) NP_001182726 NP_001153183
Location (UCSC) Chr 8:
74.9 – 74.94 Mb
Chr 1:
16.69 – 16.71 Mb
PubMed search [1] [2]

Lymphocyte antigen 96 is a protein that in humans is encoded by the LY96 gene.[1][2][3]

The protein encoded by this gene is involved in binding lipopolysaccharide with TLR 4. It is also known as "MD2".

The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccaride (LPS), thus providing a link between the receptor and LPS signaling.[3]

Interactions[edit]

Lymphocyte antigen 96 has been shown to interact with TLR 4.[1][4]

References[edit]

  1. ^ a b Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (Jul 1999). "MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4". J Exp Med 189 (11): 1777–82. doi:10.1084/jem.189.11.1777. PMC 2193086. PMID 10359581. 
  2. ^ Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M (Jul 2001). "Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide". J Immunol 167 (3): 1609–16. doi:10.4049/jimmunol.167.3.1609. PMID 11466383. 
  3. ^ a b "Entrez Gene: LY96 lymphocyte antigen 96". 
  4. ^ Re, Fabio; Strominger Jack L (Jun 2002). "Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness". J. Biol. Chem. (United States) 277 (26): 23427–32. doi:10.1074/jbc.M202554200. ISSN 0021-9258. PMID 11976338. 

Further reading[edit]


Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

External links[edit]