Lymphocyte antigen 96

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Lymphocyte antigen 96
Protein LY96 PDB 1T2Z.png
Rendering based on PDB 1T2Z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LY96 ; ESOP-1; MD-2; MD2; ly-96
External IDs OMIM605243 MGI1341909 HomoloGene9109 GeneCards: LY96 Gene
RNA expression pattern
PBB GE LY96 206584 at tn.png
More reference expression data
Species Human Mouse
Entrez 23643 17087
Ensembl ENSG00000154589 ENSMUSG00000025779
UniProt Q9Y6Y9 Q9JHF9
RefSeq (mRNA) NM_001195797 NM_001159711
RefSeq (protein) NP_001182726 NP_001153183
Location (UCSC) Chr 8:
74.9 – 74.94 Mb
Chr 1:
16.69 – 16.71 Mb
PubMed search [1] [2]

Lymphocyte antigen 96 is a protein that in humans is encoded by the LY96 gene.[1][2][3]

The protein encoded by this gene is involved in binding lipopolysaccharide with TLR 4. It is also known as "MD2".

The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccaride (LPS), thus providing a link between the receptor and LPS signaling.[3]


Lymphocyte antigen 96 has been shown to interact with TLR 4.[1][4]


  1. ^ a b Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (Jul 1999). "MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4". J Exp Med 189 (11): 1777–82. doi:10.1084/jem.189.11.1777. PMC 2193086. PMID 10359581. 
  2. ^ Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M (Jul 2001). "Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide". J Immunol 167 (3): 1609–16. doi:10.4049/jimmunol.167.3.1609. PMID 11466383. 
  3. ^ a b "Entrez Gene: LY96 lymphocyte antigen 96". 
  4. ^ Re, Fabio; Strominger Jack L (Jun 2002). "Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness". J. Biol. Chem. (United States) 277 (26): 23427–32. doi:10.1074/jbc.M202554200. ISSN 0021-9258. PMID 11976338. 

Further reading[edit]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

External links[edit]