Lynestrenol

Lynestrenol

Systematic (IUPAC) name
(8R,9R,10R,13S,14S,17S)-17-ethynyl-13-methyl- 2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro- 1H-cyclopenta[a]phenanthren-17-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	52-76-6 Y
ATC code	G03AC02
PubChem	CID 5857
ChemSpider	5648 Y
UNII	N2Z8ALG4U5 Y
KEGG	D01580 Y
Chemical data
Formula	C20H28O
Mol. mass	284.436 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,6,15-18,21H,4-5,7-13H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 Y Key:YNVGQYHLRCDXFQ-XGXHKTLJSA-N Y
Y (what is this?)  (verify)

Lynestrenol is a progestagen hormone. It is a synthetic orally-available progestagen associated with numerous effects of the natural progesterone hormone. Lynestrenol has a strong progestational effect on the uterine endometrium (transforming proliferative endometrium into secretory one), inhibits secretion of gonadotropin, suppresses maturation of follicles in the ovaries and ovulation, reduces menstrual bleeding. This synthetic gestagen is associated with minimal estrogenic, androgenic and anabolic effects. Lynestrenol is used in treatment of hormonal disorders and diseases caused by insufficient secretion of the natural progesterone, except in case of risky pregnancies and prevention of miscarriage, since it is not efficient enough in this indication.

Pharmacology

After oral administration lynestrenol is quickly resorbed and converted into pharmacologically active norethisterone, through which it demonstrates the main biological effects. The peak blood are reached within 2–4 hours after oral administration, 97% of the administered dose being bound to plasma proteins. Lynestrenol and its metabolites are predominantly excreted in the urine, less through feces, active metabolite norethisterone elimination halftime being 16-17 h.