Lysine—tRNA(Pyl) ligase

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lysine-tRNA(Pyl) ligase
Identifiers
EC number 6.1.1.25
CAS number 782472-12-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a lysine-tRNAPyl ligase (EC 6.1.1.25) is an enzyme that catalyzes the chemical reaction

ATP + L-lysine + tRNAPyl \rightleftharpoons AMP + diphosphate + L-lysyl-tRNAPyl

The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Pyl), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Pyl).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNAPyl ligase (AMP-forming).

References[edit]

  • Srinivasan G, James CM, Krzycki JA (2002). "Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA". Science. 296 (5572): 1459–62. doi:10.1126/science.1069588. PMID 12029131. 
  • Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK (2002). "A new UAG-encoded residue in the structure of a methanogen methyltransferase". Science. 296 (5572): 1462–6. doi:10.1126/science.1069556. PMID 12029132.