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Lysophosphatidylserine is a lysophospholipid which triggers TLR 2.

A recent study showed that it does not stimulate normal leukocytes.[1] It also enhances glucose transport, lowering blood glucose levels while leaving secretion of insulin unaffected.[2]


  1. ^ Park KS, Lee HY, Kim MK, Shin EH, Bae YS (2005). "Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes". Biochem. Biophys. Res. Commun. 333 (2): 353–8. doi:10.1016/j.bbrc.2005.05.109. PMID 15946646. 
  2. ^ Yea, Kyungmoo; Jaeyoon Kima, Seyoung Lima, Taewan Kwona, Ho Seon Parkb, Kyong Soo Parkb, Pann-Ghill Suha and Sung Ho Ryu (23 January 2009). "Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes". Biochemical and Biophysical Research Communications 378 (4): 783–788. doi:10.1016/j.bbrc.2008.11.122. PMID 19063864. 

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