MAGEA1

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Melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
PDB 1w72 EBI.jpg
Rendering of MAGEA1 from PDB 1W72
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAGEA1 ; CT1.1; MAGE1
External IDs OMIM300016 HomoloGene88717 GeneCards: MAGEA1 Gene
RNA expression pattern
PBB GE MAGEA1 207325 x at tn.png
PBB GE MAGEA1 210467 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4100 n/a
Ensembl ENSG00000198681 n/a
UniProt P43355 n/a
RefSeq (mRNA) NM_004988 n/a
RefSeq (protein) NP_004979 n/a
Location (UCSC) Chr HG1497_PATCH:
152.39 – 152.39 Mb
n/a
PubMed search [1] n/a

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[2]

References[edit]

  1. ^ van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID 1840703. 
  2. ^ "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)". 

Further reading[edit]