MAGEA11
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| Melanoma antigen family A, 11 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | MAGEA11; CT1.11; MAGE-11; MAGE11; MAGEA-11; MGC10511 | ||||||||||
| External IDs | OMIM: 300344 MGI: 1333834 HomoloGene: 121637 GeneCards: MAGEA11 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 4110 | 75352 | |||||||||
| Ensembl | ENSG00000185247 | ENSMUSG00000046180 | |||||||||
| UniProt | P43364 | n/a | |||||||||
| RefSeq (mRNA) | NM_001011544.1 | NM_023774.3 | |||||||||
| RefSeq (protein) | NP_001011544.1 | NP_076263.1 | |||||||||
| Location (UCSC) | Chr X: 148.77 – 148.8 Mb |
Chr X: 56.16 – 56.17 Mb |
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| PubMed search | [1] | [2] | |||||||||
Melanoma-associated antigen 11 is a protein that in humans is encoded by the MAGEA11 gene.[1][2]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.[2]
[edit] Interactions
MAGEA11 has been shown to interact with TCEA2,[3] Androgen receptor[4][5] and SH2D4A.[3]
[edit] References
- ^ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
- ^ a b "Entrez Gene: MAGEA11 melanoma antigen family A, 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4110.
- ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Bai, Suxia; He Bin, Wilson Elizabeth M (Feb. 2005). "Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction". Mol. Cell. Biol. (United States) 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. ISSN 0270-7306. PMC 548016. PMID 15684378. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=548016.
- ^ Bai, Suxia; Wilson Elizabeth M (Mar. 2008). "Epidermal Growth Factor-Dependent Phosphorylation and Ubiquitinylation of MAGE-11 Regulates Its Interaction with the Androgen Receptor". Mol. Cell. Biol. (United States) 28 (6): 1947–63. doi:10.1128/MCB.01672-07. PMC 2268407. PMID 18212060. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2268407.
[edit] Further reading
- De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
- Jurk M, Kremmer E, Schwarz U, et al. (1998). "MAGE-11 protein is highly conserved in higher organisms and located predominantly in the nucleus". Int. J. Cancer 75 (5): 762–6. doi:10.1002/(SICI)1097-0215(19980302)75:5<762::AID-IJC16>3.0.CO;2-8. PMID 9495246.
- Serrano A, Lethé B, Delroisse JM, et al. (1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". Int. J. Cancer 83 (5): 664–9. doi:10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V. PMID 10521804.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Bai S, He B, Wilson EM (2005). "Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMC 548016. PMID 15684378. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=548016.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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