MAGEA4

Melanoma antigen family A, 4
Rendering of MAGEA4 from PDB 1I4F
Available structures PDB 1I4F, 2WA0
Identifiers
Symbols	MAGEA4; CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B; MGC21336
External IDs	OMIM: 300175 MGI: 1350986 HomoloGene: 74435 GeneCards: MAGEA4 Gene
Gene Ontology Molecular function • molecular_function • protein binding Cellular component • cellular_component Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4103	195772
Ensembl	ENSG00000147381	ENSMUSG00000046301
UniProt	P43358	n/a
RefSeq (mRNA)	NM_001011548.1	NM_181855
RefSeq (protein)	NP_001011548.1	NP_862903
Location (UCSC)	Chr X: 151.08 – 151.09 Mb	Chr X: 69.12 – 69.12 Mb
PubMed search	[1]	[2]

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.

Further reading

• Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma.". Int. J. Cancer 63 (3): 375–80. doi:10.1002/ijc.2910630313. PMID 7591235. 
• Imai Y, Shichijo S, Yamada A, et al. (1995). "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.". Gene 160 (2): 287–90. doi:10.1016/0378-1119(94)00680-Q. PMID 7642112. 
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.". Immunogenetics 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540. 
• Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes.". Biochem. Biophys. Res. Commun. 202 (1): 549–55. doi:10.1006/bbrc.1994.1963. PMID 8037761. 
• De Plaen E, Naerhuyzen B, De Smet C, et al. (1997). "Alternative promoters of gene MAGE4a.". Genomics 40 (2): 305–13. doi:10.1006/geno.1996.4566. PMID 9119398. 
• Hillig RC, Coulie PG, Stroobant V, et al. (2001). "High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene.". J. Mol. Biol. 310 (5): 1167–76. doi:10.1006/jmbi.2001.4816. PMID 11502003. 
• Yutani S, Tanaka M, Mutsumoto H, et al. (2005). "Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis.". Jpn. J. Cancer Res. 93 (4): 453–8. PMID 11985796. 
• Kocher T, Zheng M, Bolli M, et al. (2002). "Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.". Int. J. Cancer 100 (6): 702–5. doi:10.1002/ijc.10540. PMID 12209610. 
• Resnick MB, Sabo E, Kondratev S, et al. (2002). "Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas.". Int. J. Cancer 101 (2): 190–5. doi:10.1002/ijc.10585. PMID 12209997. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity.". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. PMID 12525503. 
• Sarcevic B, Spagnoli GC, Terracciano L, et al. (2003). "Expression of cancer/testis tumor associated antigens in cervical squamous cell carcinoma.". Oncology 64 (4): 443–9. doi:10.1159/000070305. PMID 12759544. 
• Sakurai T, Itoh K, Higashitsuji H, et al. (2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.". J. Biol. Chem. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. PMID 14739298. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Miyahara Y, Naota H, Wang L, et al. (2006). "Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE.". Clin. Cancer Res. 11 (15): 5581–9. doi:10.1158/1078-0432.CCR-04-2585. PMID 16061876. 
• Hudolin T, Juretic A, Spagnoli GC, et al. (2006). "Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue.". Prostate 66 (1): 13–8. doi:10.1002/pros.20312. PMID 16114059. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Yoshida N, Abe H, Ohkuri T, et al. (2006). "Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.". Int. J. Oncol. 28 (5): 1089–98. PMID 16596224. 
• Peikert T, Specks U, Farver C, et al. (2006). "Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis.". Cancer Res. 66 (9): 4693–700. doi:10.1158/0008-5472.CAN-05-3327. PMID 16651421.