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Membrane associated guanylate kinase, WW and PDZ domain containing 1
Protein MAGI1 PDB 2i04.png
PDB rendering based on 2i04.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAGI1 ; AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1; Magi1d; TNRC19; WWP3
External IDs OMIM602625 MGI1203522 HomoloGene31257 GeneCards: MAGI1 Gene
RNA expression pattern
PBB GE MAGI1 206144 at tn.png
More reference expression data
Species Human Mouse
Entrez 9223 14924
Ensembl ENSG00000151276 ENSMUSG00000045095
UniProt Q96QZ7 Q6RHR9
RefSeq (mRNA) NM_001033057 NM_001029850
RefSeq (protein) NP_001028229 NP_001025021
Location (UCSC) Chr 3:
65.34 – 66.02 Mb
Chr 6:
93.68 – 94.28 Mb
PubMed search [1] [2]

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.[1][2][3]

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]


MAGI1 has been shown to interact with Calcium-activated potassium channel subunit alpha-1,[4]Beta-catenin,[5] Actinin alpha 4,[6] Brain-specific angiogenesis inhibitor 1,[1] LRP2,[7] SYNPO,[6] FCHSD2,[8] ATN1[9] and ACCN3.[10]


  1. ^ a b Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (July 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem Biophys Res Commun 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739. 
  2. ^ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (July 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. 
  3. ^ a b "Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1". 
  4. ^ Ridgway, LD; Kim EY; Dryer SE (July 2009). "MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface.". Am J Physiol Cell Physiol. (UNITED STATES) 297 (1): C55–65. doi:10.1152/ajpcell.00073.2009. PMID 19403801. 
  5. ^ Dobrosotskaya, I Y; James G L (April 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. ISSN 0006-291X. PMID 10772923. 
  6. ^ a b Patrie, Kevin M; Drescher Andrew J; Welihinda Ajith; Mundel Peter; Margolis Ben (August 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. (United States) 277 (33): 30183–90. doi:10.1074/jbc.M203072200. ISSN 0021-9258. PMID 12042308. 
  7. ^ Patrie, K M; Drescher A J; Goyal M; Wiggins R C; Margolis B (April 2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". J. Am. Soc. Nephrol. (United States) 12 (4): 667–77. ISSN 1046-6673. PMID 11274227. 
  8. ^ Ohno, Hideki; Hirabayashi Susumu, Kansaku Ai, Yao Ikuko, Tajima Makiko, Nishimura Wataru, Ohnishi Hirohide, Mashima Hirosato, Fujita Toshiro, Omata Masao, Hata Yutaka (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene (England) 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. ISSN 0950-9232. PMID 14627983. 
  9. ^ Wood, J D; Yuan J; Margolis R L; Colomer V; Duan K; Kushi J; Kaminsky Z; Kleiderlein J J; Sharp A H; Ross C A (June 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. (UNITED STATES) 11 (3): 149–60. doi:10.1006/mcne.1998.0677. ISSN 1044-7431. PMID 9647693. 
  10. ^ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. (United States) 279 (45): 46962–8. doi:10.1074/jbc.M405874200. ISSN 0021-9258. PMID 15317815. 

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